Researchers from the Columbia University Medical Center, published a new paper in Nature Bitechnology, describing a novel method for generation of functional lung cells from pluripotent stem cells. Their highly-efficient differentiation method resulted in the formation of clara, ciliated, type I and type II alveolar epithelial cells.
In a new paper published this week online in Nature, a team from the Perelman School of Medicine, University of Pennsylvania, shows that the pulmonary vasculature, the blood vessels that connect the heart to the lung, develops even in the absence of the lung. Mice in which lung development is inhibited still have pulmonary blood vessels, which revealed to the researchers that cardiac progenitors, or stem cells, are essential for cardiopulmonary co-development.
Jacob Blumenthal's insight:
In a paper published online in Nature, the researchers show that the murine pulmonary vasculature develops even in the absence of lung development. They have identified a population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart that are marked by the expression of Wnt2, Gli1 and Isl1. In addition, they demonstrated that CPPs arise from cardiac progenitors before lung development. They found that CPPs are regulated by hedgehog expression from the foregut endoderm, which is required for connection of the pulmonary vasculature to the heart.
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