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Epilepsy in a dish: Stem cell research reveals clues to disease's origins and ... - Medical Xpress

Epilepsy in a dish: Stem cell research reveals clues to disease's origins and ... - Medical Xpress | Stem Cells & Tissue Engineering | Scoop.it

A new stem cell-based approach to studying epilepsy has yielded a surprising discovery about what causes one form of the disease, and may help in the search for better medicines to treat all kinds of seizure disorders.

The findings, reported by a team of scientists from the University of Michigan Medical School and colleagues, use a technique that could be called "epilepsy in a dish".
Jacob Blumenthal's insight:

Researchers from the University of Michigan Medical School, have generated induced pluripotent stem (iPS) cells from epilepsy patients, and further differentiated them into forebrain-like pyramidal- and bipolar-shaped neurons. The iPSC were derived from skin samples of patients with Dravet syndrome (DS), a severe childhood epilepsy typically caused by de novo dominant mutations in the SCN1A gene encoding the voltage-gated sodium channel Nav1.1.

The researchers compared DS and control iPSC-derived neurons using whole-cell patch clamp recordings and evaluated their sodium current density and intrinsic neuronal excitability. 

This work is another good example for the use of iPS as a cellular model for various diseases.

http://onlinelibrary.wiley.com/doi/10.1002/ana.23897/abstract

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Stem cells found to cure epilepsy in mice - World Science - World Science

Fars News Agency
Stem cells found to cure epilepsy in mice - World Science
World Science
Stem cells found to cure epilepsy in mice. May 6, 2013. Courtesy of UCSF and World Science staff.
Jacob Blumenthal's insight:

Re­search­ers transplant  em­bry­on­ic stem cells-derived GABA progenitor cells, in­to the hip­po­cam­pus, a brain re­gion as­so­ci­at­ed with seizures, as well as learn­ing and mem­o­ry. They report that the transplanted cells expressed interneurons genes and proteins and differentiated into functional inhibitory neurons.

A link to the abstract: http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3392.html

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