An article published on 4/7 brings valuable info. for those of you that are interested in epigenomics.
From the abstract: "Over the past years we have witnessed an explosion in the generation of freely available genome-wide data sets, including maps of various histone modifications, transcription factor binding, DNase hypersensitivity, and DNA methylation, which provide valuable resources for data validation, exploration, and hypothesis generation. The goal of this review is to provide the reader with information on where to find many of the data sets and how to utilize the various (epi)genome browsers for display and initial analysis. We provide selected examples to highlight key features and demonstrate the application of these browsers to stem cell biology."
A chemical code scrawled on histones -- the protein husks that coat DNA in every animal or plant cell -- determines which genes in that cell are turned on and which are turned off.
Jacob Blumenthal's insight:
In a study published June 27 in Cell Reports, the researchers explored the chromatin features of adult skeletal muscle stem cells from young and old mice. By comparing the epigenetic profiles of these cells, the authors provided a direct evidence that, with age, epigenetic changes accumulate and may lead to a functional decline in quiescent stem cells. Their findings highlight the importance of chromatin mapping in understanding the unique features of stem cell identity and stem cell aging.
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