Researchers from Swiss have successfully performed nose reconstruction surgery with cartilage grown from the patient’s own tissue. First, the researchers isolated small biopsies from the nose of patients who suffer from severe nose defects from skin cancer surgery. Then, cartilage cells were isolated from this biopsies and cultured in-vitro. At the end of the expansion period, the samples had grown to 40 times their original size. The cultured tissues were then shaped according to the patient’s defect and implanted back to the patients.
Stem cell researchers from UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have published the first study to identify the origin cells and track the early development of human articular cartilage, providing what...
Jacob Blumenthal's insight:
Researchers from UCLA found that recapitulation of the human developmental chondrogenic program using pluripotent stem cells (PSCs) is a more efficient way to generate articular cartilage thenusin adult stem/progenitor cells. They published their findins in "Stem Cell Reports": http://www.cell.com/stem-cell-reports/abstract/S2213-6711(13)00124-0
To learn about the embryonic development of articular cartilage:
Summary: "The face distinguishes one person from another. Postnatal orofacial tissues harbor rare cells that exhibit stem cell properties. Despite unmet clinical needs for reconstruction of tissues lost in congenital anomalies, infections, trauma, or tumor resection, how orofacial stem/progenitor cells contribute to tissue development, pathogenesis, and regeneration is largely obscure. This perspective article critically analyzes the current status of our understanding of orofacial stem/progenitor cells, identifies gaps in our knowledge, and highlights pathways for the development of regenerative therapies".
Jacob Blumenthal's insight:
This is a free review from Cell Stem Cell describing stem cells in the face. It was first published in September 2012, and is now available as part of the Featured Five review collection.
To learn more about the embryonic development of the head mesenchyme and the bones:
Abstract: "The maintenance of a critical threshold concentration of TGF-β for a given period of time is crucial for the onset and maintenance of chondrogenesis. Thus, the development of scaffolds that provide temporal and/or spatial control of TGF-β bioavailability has appeal as a mechanism to induce the chondrogenesis of stem cells in vitro and in vivo for articular cartilage repair. In the past decade, many types of scaffolds have been designed to advance this goal: hydrogels based on polysaccharides, hyaluronic acid, alginate; protein-based hydrogels such as fibrin, gelatin, collagens; biopolymeric gels and synthetic polymers; and solid and hybrid composite (hydrogel/solid) scaffolds. Here, we review the progress in developing strategies to deliver TGF-β from scaffolds with the aim of enhancing chondrogenesis. In the future, such scaffolds could prove critical for tissue engineering cartilage, both in vitro and in vivo".
Researchers from Duke combined synthetic scaffolds with viral gene delivery techniques to generate cartilage-secreting human mesenchymal stem cells (hMSCs). The researchers first immobilized lentivirus to poly(ε-caprolactone) films. Then they demonstrated that scaffold-mediated gene delivery of transforming growth factor β3 (TGF-β3), using a 3D woven poly(ε-caprolactone) scaffold, promoted cartilaginous ECM production by hMSCs.
Cartilage injury and lack of cartilage regeneration often lead to osteoarthritis, which involves degradation of joint components, including articular cartilage and subchondral bone. In a new open-access paper published in Stem Cell Reports, the authors explored the developmental cues governing articular cartilage geneartion in-vivo. They followed the developmental progression of primordial mesenchymal cells towards...(click on the image/link to read the full story).
In a paper poublished today in Plos ONE, Outani et al, describe a new method for direct reprogramming of skin fibroblasts into chondrogenic cells. They introduced 3 genes: c-MYC, KLF4, and SOX9 into mouse dermal fibroblasts and turned them into cartilage chondrogenic cells (iChon). The induced cells expressed chondrocyte-specific markers, and formed cartilage upon transplantation into nude mice.
Plastic surgeons in the US say they have moved a step closer to being able to grow a complete human ear from a patient's cells.
Jacob Blumenthal's insight:
Scientist were able to grow a human-like ear made from animal tissue on a titanium scaffold. The ear geometry was redesigned to achieve a more accurate aesthetic result when implanted subcutaneously in a nude rat model. A non-invasive method was developed to assess size and shape changes of the engineered ear in three dimensions. Computer models of the titanium framework were obtained from CT scans before and after implantation This work is another step towards the design "real" artificial organs.
Sharing your scoops to your social media accounts is a must to distribute your curated content. Not only will it drive traffic and leads through your content, but it will help show your expertise with your followers.
How to integrate my topics' content to my website?
Integrating your curated content to your website or blog will allow you to increase your website visitors’ engagement, boost SEO and acquire new visitors. By redirecting your social media traffic to your website, Scoop.it will also help you generate more qualified traffic and leads from your curation work.
Distributing your curated content through a newsletter is a great way to nurture and engage your email subscribers will developing your traffic and visibility.
Creating engaging newsletters with your curated content is really easy.