Stem Cells & Tiss...
Follow
49.9K views | +0 today
Stem Cells & Tissue Engineering
Stem Cells & Tissue Engineering  news and updates
Your new post is loading...
Your new post is loading...
Scooped by Jacob Blumenthal
Scoop.it!

Scientific Breakthrough as Artificial Blood is Created from Stem Cells

Scientific Breakthrough as Artificial Blood is Created from Stem Cells | Stem Cells & Tissue Engineering | Scoop.it
Mass production of human blood could become reality as artificial blood is tested on patients for the first time.
Jacob Blumenthal's insight:

British researchers have announced that after 4 years of research their Blood Pharma programme has made enough progress turning stem cells into red blood cells to move to clinical trials by late 2016. The researchers use both human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) to generate blood cells in-vitro. They differentiate them into red blood cells, and expand their number in culture. The last differentiation stage is when the  developing blood cells eject their DNA to adopt the enucleated state characteristic of red blood cells.

Learn more about blood development and related stem cell differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/blood

more...
Scooped by Jacob Blumenthal
Scoop.it!

A*STAR scientists create stem cells from drop of blood - Channel NewsAsia

A*STAR scientists create stem cells from drop of blood - Channel NewsAsia | Stem Cells & Tissue Engineering | Scoop.it

Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have developed a method to generate human induced pluripotent stem cells (hiPSCs) from a single drop of finger-pricked blood.

Jacob Blumenthal's insight:

Researchers from  A*STAR's Institute of Molecular and Cell Biology (IMCB)  have developed a method for derivation of induced pluripotent stem cells (iPSCs) from a single drop of blood. The main achievement in this research is that the volume of a single blood is sufficient for the production of iPSCs. This approach will make the establishement of iPSCs banks easier .

Learn more about iPSCs:

http://discovery.lifemapsc.com/stem-cell-differentiation

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Adult Stem Cells Help Build Human Blood Vessels in Engineered Tissues

Adult Stem Cells Help Build Human Blood Vessels in Engineered Tissues | Stem Cells & Tissue Engineering | Scoop.it
Chicago, IL (Scicasts) – Researchers at the University of Illinois at Chicago have identified a protein expressed by human bone marrow stem cells that guides and stimulates the formation of blood vessels.
Jacob Blumenthal's insight:

Researchers from the university of Illinois studied the effect of mesenchymal stem cells (MSCs) on the formation of vascular networks in-vitro. They found that “pericytic” MSCs secrete the pro-angiogenic vascular guidance molecule SLIT3, which guides vascular development by directing ROBO4-positive endothelial cells to form networks in engineered tissue. In contrast, “non-pericytic” MSCs exhibit reduced activation of the SLIT3/ROBO4 pathway and do not support vascular networks. 

http://www.sciencedirect.com/science/article/pii/S002228281300268X

 

To learn about endothelial cells embryonic development:

http://discovery.lifemapsc.com/in-vivo-development/endothelium

more...
Carlos Garcia Pando's comment, October 15, 2013 1:37 PM
This is it! Now the road is much more clear for 3d printing tissue
Carlos Garcia Pando's curator insight, October 15, 2013 1:38 PM

Wonderful discovery that paves the road to complex (and big) 3d printed functional tissue

Scooped by Jacob Blumenthal
Scoop.it!

Reprogrammed cells generate blood vessels

Reprogrammed cells generate blood vessels | Stem Cells & Tissue Engineering | Scoop.it
Harvard researchers have generated long-lasting blood vessels from reprogrammed human cells. The study in the mouse model reveals both the potential and remaining challenges to vessel regeneration.
Jacob Blumenthal's insight:

In their report published in  Proceedings of the National Academy Of Sciences (PNAS) early edition, the investigators describe using iPSCs — reprogrammed adult cells that have many of the characteristics of embryonic stem cells — both from healthy adults and from individuals with type 1 diabetes to generate blood vessels on the outer surface of the brain or under the skin of mice (taken from the "Harvard gazette").

http://www.pnas.org/content/early/2013/07/16/1310675110

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

CIRM Stem Cell Research Updates: 25 year anniversary of the blood-forming stem cell discovery

Jacob Blumenthal's insight:

25 years ago, Irv Weissman of Stanford University published the first paper about isolation of stem cells from animal tissues (from the bone-marrow of mouse). Ten years later, he isolated the cells from humans.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

DURHAM: Duke surgeon conducts first US human trial with engineered blood vessel | Health & Science | NewsObserver.com

DURHAM: Duke surgeon conducts first US human trial with engineered blood vessel | Health & Science | NewsObserver.com | Stem Cells & Tissue Engineering | Scoop.it
A Duke surgeon performed the first US implantation of an engineered blood vessel Wednesday. The technology uses a person’s own cells to build the vein, reducing the wait time for patients needing veins.
more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Scots scientists to trial synthetic human blood - Health - Scotsman.com

Scots scientists to trial synthetic human blood - Health - Scotsman.com | Stem Cells & Tissue Engineering | Scoop.it
SCOTTISH scientists have been given the go-ahead for the world’s first trials in humans of synthetic blood, The Scotsman can reveal. (Go ahead for trials to make blood from stem cells. Well done those folks @RoslinCells, SCRM and SNBTS.
more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Making red blood cells: A model of stem cell therapy development

Making red blood cells: A model of stem cell therapy development | Stem Cells & Tissue Engineering | Scoop.it
() Translating laboratory research into cell therapies raises many complex questions and challenges for both science and society.
Jacob Blumenthal's insight:

This is a nice commentary, describing the advatages of stem cells-derived blood cells.

Here is a link to the "stem cells for blood" project: 

http://www.stemcellsforblood.org/about.htm

More information about protocols for generation of blood cells from pluripotent stem cells can be found in the Lifemap Discovery database : 

discovery.lifemapsc.com

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells: Cell Stem Cell

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells: Cell Stem Cell | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

A new paper in Cell Stem Cell describes a novel protocol for generation of stable immortalized megakaryocyte progenitor cell lines (imMKCLs) from human pluripotent stem cells (hPSC). The researchers derived imMKCLs from PSC-derived hematopoietic progenitors by overexpression of BMI1, BCL-XL , and c-MYC.

The derived  imMKCLs  have robust expansion capacity and can differentiate into mature megakaryocytes that release functional platelets. These characteristics makes them an ideal inexhaustible source of hPSC-derived platelets for clinical applications. 


Learn more about stem cells and differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation


more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

2013 CSHL Symposium Interview: Dr. Irving Weissman

Jacob Blumenthal's insight:

A great interview with Dr. Irving Weissman about his research and his thoughts on the stem cell field.

Learn more about stem cells:

http://discovery.lifemapsc.com/stem-cell-differentiation

more...
David O'Connell's curator insight, February 6, 2014 11:07 AM
Jacob Blumenthal's insight:

A great interview with Dr. Irving Weissman about his research and his thoughts on the stem cell field.

Learn more about stem cells:

http://discovery.lifemapsc.com/stem-cell-differentiation

Scooped by Jacob Blumenthal
Scoop.it!

Cell Stem Cell - Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs

Cell Stem Cell - Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from McMaster university, Canada published a paper in Cell Stem Cell journal, discussing the regional localization of hematopoietic stem cells (HSCs) withing the bone marrow. They found that HSC tend to localize to endosteal regions of the trabecular bone area (TBA). These cells have superior regenerative and self-renewal capacity and are molecularly distinct from those localizing to the long bone area (LBA).

This important paper, reveals that bone marrow localization is important to define the functional propeties of HSCs.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Gene Therapy Coming of Age? | The Scientist Magazine®

Gene Therapy Coming of Age? | The Scientist Magazine® | Stem Cells & Tissue Engineering | Scoop.it
Using lentiviral vectors to replace mutated genes in blood stem cells, scientists successfully treat two rare diseases apparently without causing harmful side effects.
more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Cell Stem Cell - FeaturedFive Review collection

Jacob Blumenthal's insight:

Last chance to read this month free reviews on:

 

1. Mesenchymal stromal cells

2. The stem cell nieche

3.Pluripotent stem cells and Huntington's disease

4. Expanding the boundries of embryonic stem cells

5. Red blood cells from embryonic stem cells

 

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Stem Cells Freak: New method to produce red blood cells from stem cells

Stem Cells Freak: New method to produce red blood cells from stem cells | Stem Cells & Tissue Engineering | Scoop.it
Researchers from the Boston University and the Boston Medical Centre have developed a new iPSCs-based method to produce human red blood cells and platelets.
Jacob Blumenthal's insight:

This is a new paper (30.5): 

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

http://www.ncbi.nlm.nih.gov/pubmed/23723449

more...
Carlos Garcia Pando's comment, June 2, 2013 1:57 PM
great. Thanks
Carlos Garcia Pando's curator insight, June 2, 2013 2:01 PM

Apart from the importance of this result, and the obvious benefit for human kind, this also brings an end to vampire stories-Blade and the undead- as they will not need to hunt for blood.

Scooped by Jacob Blumenthal
Scoop.it!

Tissue engineering: Growing new organs, and more - MIT News Office

Tissue engineering: Growing new organs, and more - MIT News Office | Stem Cells & Tissue Engineering | Scoop.it
Research could lead to better ways to heal injuries and develop new drugs. (RT @CIMIT: Growing new organs and more!
Jacob Blumenthal's insight:

The paper: 

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

http://www.nature.com/nmat/journal/v11/n9/full/nmat3357.html

more...
No comment yet.