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Rescooped by Wayne Channon from #ALS AWARENESS #LouGehrigsDisease #PARKINSONS
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Biomaterials Offer A Robust Platform For Stem Cells

Biomaterials Offer A Robust Platform For Stem Cells | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Prof. Molly Shoichet (photo courtesy of Shoichet Lab) One of the challenges facing stem cell researchers is how to ensure that cells delivered to patients don't die after transplantation to the point of care.

Via TEAM Mike Lopez Memorial Foundation |Find us on Twitter:@TEAMCUREALS
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A possible way of keeping stem cells at the point of insertion or even keeping them alive following transplant.

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Stem cells for treatment of ALS at Mayo Clinic - YouTube

Researchers in the Center for Regenerative Medicine are studying the use of intraspinal deliver of mesenchymal stem cells (MSCs) to the cerebral spinal fluid...

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Jacob Blumenthal's curator insight, March 9, 1:11 AM

This is a nice movie illustrating the process of isolation and transplantation of growth factor secreting-mesenchymal stem cells (MSCs) for the treatment of amyotrophic lateral sclerosis (ALS), currently being held at the Mayo Clinic.

Join my Facebook group for more stem cells news and updates:

 https://www.facebook.com/groups/STEMCELLSNET/

 

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Parkinson’s stem cell project aims for 2014 approval

Parkinson’s stem cell project aims for 2014 approval | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
For eight local Parkinson’s patients seeking stem cell therapy, 2014 could be a milestone.

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Jacob Blumenthal's curator insight, December 14, 2013 10:29 AM

A new Parkinson’s stem cell project, aims to replace the damaged neuronal cells in the patient's brain with neurons that will be derived from he patient's own cells. This article, describes the time table and the funding issues behind this project

 
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Mini-pancreas grown from stem cells has implications for future insulin delivery

Mini-pancreas grown from stem cells has implications for future insulin delivery | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

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Jacob Blumenthal's curator insight, October 16, 2013 2:02 AM

In a paper, published in Development journal, researchers from the  Danish Stem Cell Centre have shown that they can culture mouse pancreatic cells into expanded, branched structures in a 3D culture.

By manipulating the medium composition they  generated either hollow spheres, which are mainly composed of pancreatic progenitors, or complex organoids that spontaneously undergo pancreatic morphogenesis and differentiation.

Manipulation and improvement of  culture and expansion techniques 

 could lead to a more efficient and  developed method of creating insulin-releasing beta cells, which will eventually be used for cell therapy of diabetes.

http://dev.biologists.org/content/140/21/4452.full

 

To learn about pancreatic development:

http://discovery.lifemapsc.com/in-vivo-development/pancreas

 

To learn about stem cells differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

 

Carlos Garcia Pando's curator insight, October 16, 2013 2:04 PM

Another wonder result from tissue engineering!

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Endothelial Cells Can Repair and Regenerate Organs, Researchers Find | Medicine | Sci-News.com

Endothelial Cells Can Repair and Regenerate Organs, Researchers Find | Medicine | Sci-News.com | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Damaged or diseased human organs may someday be healed with an injection of engineered endothelial cells.
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An Organized Approach to 3D Tissue Engineering

An Organized Approach to 3D Tissue Engineering | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

Researchers at the Institute of Bioengineering and Nanotechnology (IBN) have developed a simple method of organizing cells and their microenvironments in hydrogel fibers. Their unique technology provides a feasible template for assembling complex structures, such as liver and fat tissues, as described in their recent publication in Nature Communications.


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Jacob Blumenthal's curator insight, August 27, 2013 3:05 AM

Researchers from the Institute of Bioengineering and Nanotechnology (IBN) in Singapore, have used interfacial polyelectrolyte complexation (IPC) fiber assembly, a unique cell patterning technology patented by IBN, to produce cell-laden hydrogel fibers under aqueous conditions at room temperature. Unlike other methods, IBN’s novel technique allows researchers to incorporate different cell types separately into different fibers, and these cell-laden fibers may then be assembled into more complex constructs with hierarchical tissue structures. In addition, IBN researchers are able to tailor the microenvironment for each cell type for optimal functionality by incorporating the appropriate factors, e.g. proteins, into the fibers. Using IPC fiber assembly, the researchers have engineered an endothelial vessel network, as well as cell-patterned fat and liver tissue constructs, which have successfully integrated with the host circulatory system in a mouse model and produced vascularized tissues. 

 

http://www.nature.com/ncomms/2013/130819/ncomms3353/full/ncomms3353.html

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* I would like to thank Dr. Karthikeyan Narayanan, for the paper information and pictures presented in the post.

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Reprogramming cells by computer | KurzweilAI

Reprogramming cells by computer | KurzweilAI | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have developed a model that makes predictions that allow for deciding which differentiated cells — for instance skin cells — can be very efficiently changed into completely different cell types — such as nerve cells, for example.


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'Big leap' towards curing blindness

'Big leap' towards curing blindness | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
The prospect of reversing blindness has made a significant leap, according to scientists in London. (Curing blindness-I've been saying for years that stem cells are our single biggest hope....

Via Ella Buzhor
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This study shows that ESCs can provide a source of photoreceptors for retinal cell transplantation.

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Ella Buzhor's curator insight, July 22, 2013 3:27 AM

ESC-derived photoreceptors (at a developmental stage similar to postnatal days 4–8) integrate within degenerate retinas of adult mice and mature into outer segment–bearing photoreceptors.  This study shows that ESCs can provide a source of photoreceptors for retinal cell transplantation.


http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.2643.html

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Cord Stem Cells a Potential Arthritis Treatment

Cord Stem Cells a Potential Arthritis Treatment | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Umbilical cord stem cells may be useful in the treatment of rheumatoid arthritis.

Via Ella Buzhor
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Umbilical cord blood stem cells could be the future of regenerative medicine.

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Liver Tissue Created From Stem Cells by Scientists in Japan, 'Proof-of-Concept' That New Organs Can Be Made for Transplants

Liver Tissue Created From Stem Cells by Scientists in Japan, 'Proof-of-Concept' That New Organs Can Be Made for Transplants | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

Scientists in Japan have created an early liver like those in fetuses from human stem cells.

According to the research published in the journal Nature, the "buds" didn't grow into regular livers, but they do show serious steps toward creating new organs for transplants, Bloomberg reported.


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Huntington’s disease: how could stem cells help?

Huntington’s disease: how could stem cells help? | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
What is Huntington’s disease?Huntington’s Disease (HD) mainly affects nerve cells in the brain called medium spiny neurons (MSNs). MSNs receive and coordinate information from other neurons in the brain to control movement of the body, face and eyes.

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Ella Buzhor's curator insight, July 7, 2013 6:42 AM

Comprehensive explanation of the possible benefits of the stem cell tharapy to Huntington’s Disease treatment. Emphasizing the need of the replacemant of the lost cells ( medium spiny neurons)  in the brain.

Rescooped by Wayne Channon from #ALS AWARENESS #LouGehrigsDisease #PARKINSONS
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Biomaterials Offer A Robust Platform For Stem Cells

Biomaterials Offer A Robust Platform For Stem Cells | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Prof. Molly Shoichet (photo courtesy of Shoichet Lab) One of the challenges facing stem cell researchers is how to ensure that cells delivered to patients don't die after transplantation to the point of care.

Via TEAM Mike Lopez Memorial Foundation |Find us on Twitter:@TEAMCUREALS
Wayne Channon's insight:

A possible way of keeping stem cells at the point of insertion or even keeping them alive following transplant.

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Living brain cells made from patients’ biobanked brain tissue

Living brain cells made from patients’ biobanked brain tissue | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

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Jacob Blumenthal's curator insight, January 7, 2:48 PM

In a collaborative effort between scientists at The New York Stem Cell Foundation Research Institute, and scientists from Columbia University Medical Center,  induced pluripotent stem (iPS) cells lines were successfully generated from non-cryoprotected brain tissue of patients with Alzheimer’s disease (AD). This process will allow neurobiologists to follow the development of AD, and perhaps to identify early cellular markers of the disease, before AD clinically symptoms are displayed.

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Cell Death and Differentiation - Immunobiology of mesenchymal stem cells

Cell Death and Differentiation - Immunobiology of mesenchymal stem cells | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

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Jacob Blumenthal's curator insight, November 5, 2013 2:22 PM

Mesenchymal stem cells play an important role in cell therapy and are being currently tested in clinical trials for a variety of diseases. This open-access paper focus on their immunomodulatory effect.

 

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Mesenchymal Stem Cells for Treatment of Ischemic Kidney Disease

Mesenchymal Stem Cells for Treatment of Ischemic Kidney Disease | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

Mesenchymal stem cells (MSCs) confer renal protection mostly through trophic effects. Their anti-inflammatory and immune-modulatory properties target multiple cascades underlying ischemic kidney disease. A review recently published in STEM CELLS, focuses on progress in the application of MSCs in cell therapy to prevent kidney failure arising from ischemic kidney injury.


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Unique Stem Cell Therapy for MS Patients

Unique Stem Cell Therapy for MS Patients | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Doctors have been exploring the possibility of stem cells to treat and possibly cure Multiple Sclerosis (MS). In the past few days the Food and Drug Administration (FDA) has approved a brand new pa...

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Ella Buzhor's curator insight, September 1, 2013 3:45 AM

Phase I clinical trial will investigate the safety and efficacy of autologous, mesenchymal stems cell-derived neural progenitor cells (MSC-NPs) in the treatment of progressive MS.

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Rise of Cell Therapy Trials for Stroke: Review of Published and Registered Studies

Rise of Cell Therapy Trials for Stroke: Review of Published and Registered Studies | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it

There were31 articles in the English language involving 20 different trials of cell therapies for stroke,


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Ella Buzhor's curator insight, August 14, 2013 4:30 AM

The results indicate that cell therapies can lead to the structural and functional benefits after a stroke. However, there is still a need to examine the ideal therapeutic cell source. Cell therapy seem to be safe, feasible, and potentially efficacious.

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'Artificial bones' generated from umbilical cord stem cells

'Artificial bones' generated from umbilical cord stem cells | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Scientists have successfully developed 'artificial bones' from umbilical cord stem cells, paving way for repair of bones. ('Artificial bones' generated from umbilical cord stem cells...

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New tissue engineering breakthrough encourages nerve repair

New tissue engineering breakthrough encourages nerve repair | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
A new combination of tissue engineering techniques could reduce the need for nerve grafts, according to new research by The Open University.

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Stem cells in the aesthetic industry: an interview with Dr. Norma Kassardjian

Stem cells in the aesthetic industry: an interview with Dr. Norma Kassardjian | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Stem Cells are special “master” cells in your body. Stem cells are the building blocks that can replicate into other kinds of cells like blood cells, heart, muscle, blood vessels and cartilage.
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Tissue engineering: How to build a heart

Tissue engineering: How to build a heart | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
With thousands of people in need of heart transplants, researchers are trying to grow new organs.

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10 talks on the future of stem cell medicine | TED Blog

10 talks on the future of stem cell medicine | TED Blog | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
Will the next generation think about diseases like Alzheimer’s and diabetes the way we think about polio and the whooping cough? Susan Solomon, the co-founder of the New York Stem Cell Foundation (NYSCF), certainly hopes so.

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Jacob Blumenthal's curator insight, June 27, 2013 4:11 AM

This is a great collection of talks from TED! Highly recommended!

Bettina Ascaino's curator insight, December 15, 2013 12:46 AM

 A collection of TED talks highly recommended by Jacob Blumenthal

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Scientists Discover Stem Cells In Fat

Scientists Discover Stem Cells In Fat | Stem Cells, Regenerative Medicine & Tissue Engineering | Scoop.it
By Karen Hopkin(Click here for the original article and podcast) Stem cells are prized for their ability to give rise to a variety of specialized cell types, including heart, liver, nerve and bone.
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Pluripotent stem cells from fat that are induced by stress... could be used for repair of damaged or diseased tissue.

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