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LifeMap Discovery - Introduction - YouTube

LifeMap Discovery (http://discovery.lifemapsc.com) is a compendium of embryonic development, stem cell research and regenerative medicine, constructed by int...

Via Jacob Blumenthal
Joe Riggs's insight:

LifeMap Discovery is an unprecedented interactive user-friendly searchable database that provides comprehensive coverage of  stem cell research and developmental biology. Contains important protocols for differentiation, gene expression profiles, and more. The team at the Student Society for Stem Cell Research (SSSCR) is impressed by the educational potential of this platform and its significance for the research community.

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Jacob Blumenthal's curator insight, January 15, 2014 2:59 PM

View this introductory video on LifeMap Discovery database for the use of stem cell researchers, developmental biologists, and regenerative medicine experts!

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ViaCyte's VC-01™ Investigational Stem Cell-Derived Islet Replacement Therapy Successfully Implanted into First Patient

ViaCyte's VC-01™ Investigational Stem Cell-Derived Islet Replacement Therapy Successfully Implanted into First Patient | Stem-Cells | Scoop.it
SAN DIEGO, Oct. 29, 2014 /PRNewswire/ -- ViaCyte, Inc., a privately-held regenerative medicine company, announced...
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3D Tissue Printing Technique Could Advance Stem Cell Research

3D Tissue Printing Technique Could Advance Stem Cell Research | Stem-Cells | Scoop.it
A team of researchers at Rensselaer Polytechnic Institute (RPI) plans to apply their novel 3D printing technique to stem cell research — using...
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Researchers develop powerful single-cell epigenetic methylation mapping to study environmental effects on DNA

Researchers develop powerful single-cell epigenetic methylation mapping to study environmental effects on DNA | Stem-Cells | Scoop.it

Researchers at the BBSRC-funded Babraham Institute, in collaboration with the Wellcome Trust Sanger Institute Single Cell Genomics Centre, have developed a powerful new single-cell technique to help investigate how the environment affects our development and the traits we inherit from our parents. The technique can be used to map all of the ‘epigenetic marks’ on the DNA within a single cell.  This single-cell approach will boost understanding of embryonic development, could enhance clinical applications like cancer therapy and fertility treatments, and has the potential to reduce the number of mice currently needed for this research.

 

‘Epigenetic marks’ are chemical tags or proteins that mark DNA and act as a kind of cellular memory. They do not change the DNA sequence but record a cell’s experiences onto the DNA, which allows cells to remember an experience long after it has faded. Placing these tags is part of normal development; they tell genes whether to be switched on or off and so can determine how the cell develops. Different sets of active genes make a skin cell different from a brain cell, for example. However, environmental cues such as diet can also alter where epigenetic tags are laid down on DNA and influence an organism’s long-term health.

 

Dr Gavin Kelsey, from the Babraham Institute, said: “The ability to capture the full map of these epigenetic marks from individual cells will be critical for a full understanding of early embryonic development, cancer progression and aid the development of stem cell therapies.

 

“Epigenetics research has mostly been reliant on using the mouse as a model organism to study early development. Our new single-cell method gives us an unprecedented ability to study epigenetic processes in human early embryonic development, which has been restricted by the very limited amount of tissue available for analysis.”

 

The new research, published in Nature Methods, offers a new single-cell technique capable of analysing DNA methylation – one of the key epigenetic marks – across the whole genome. The method treats the cellular DNA with a chemical called bisulphite. Treated DNA is then amplified and read on high-throughput sequencing machines to show up the location of methylation marks and the genes being affected.

 

These analyses will help to define how epigenetic changes in individual cells during early development drive cell fate. Current methods observe epigenetic marks in multiple, pooled cells. This can obscure modifications taking place in individual cells at a time in development when each cell has the potential to form in a unique way. The new method has already revealed that many of the methylation marks that differ between individual cells are precisely located in sites that control gene activity.


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The Promise of Stem Cell Research - Dr. Paul Knoepfler

Dr. Paul Knoepfler from UC Davis School of Medicine and author of "Stem Cells - An Insider's Guide" discusses the research and future of stem cells. http://w...

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Jacob Blumenthal's curator insight, April 17, 2014 11:57 AM

In this video interview Dr. Paul Knoepfler talks about stem cell therapy, induced pluripotent stem cells (iPSCs) and STAP stem cells.

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New cell line should accelerate embryonic stem cell research - Phys.Org

New cell line should accelerate embryonic stem cell research - Phys.Org | Stem-Cells | Scoop.it
Phys.Org New cell line should accelerate embryonic stem cell research Phys.Org Researchers had been able to develop naive cells using mouse embryonic stem cells but to create naive human embryonic stem cells has required inserting a set of genes...
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CIRM Stem Cell Research Updates: Secrets of hibernating bears & stem cells lead to potential path to early cancer detection

CIRM Stem Cell Research Updates: Secrets of hibernating bears & stem cells lead to potential path to early cancer detection | Stem-Cells | Scoop.it
Secrets of cuddly babies, hibernating bears & #stemcells lead to potential path to early detection of #cancer http://t.co/DGMPnoUL4u
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Building a Kidney: Using Pluripotent Stem Cells to Differentiate Kidney Structures

Building a Kidney:  Using Pluripotent Stem Cells to Differentiate Kidney Structures | Stem-Cells | Scoop.it

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Jacob Blumenthal's curator insight, March 4, 2014 2:19 AM

Kidneys develop from the intermediate metanephros (IM), which gives rise to the metanephric mesenchyme (MM) and the ureteric bud (UB). The MM forms the glomerulus and the renal tubules while the UB differentiates into the collecting duct. Reciprocal interactions between the MM and the UB are necessary for development of the kidney. Both the MM and the UB contain stem cells, however, once these cells are removed from their respective niches, they spontaneously terminally differentiate, rendering, creation of kidney structures in vitro very difficult. Recently, two papers (from Nishinakamura and Little's research groups) describe the use ... (Read the full story in the newsletter).

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Funding Opportunities - Stem Cell Network

RT @StemCellNetwork: We've just re-launched FOUR (!) research awards for undergrad students in Canada, apply today: http://t.co/bHaA8H2zV7
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Standartization issues to be taken care for the development of cell therapy products

Standartization issues to be taken care for the development of cell therapy products | Stem-Cells | Scoop.it
To manufacture stem cells for cell therapy, standards for other materials critical for the cells' growth and survival must also be considered. (Do you know what ancillary materials are needed in order to manufacture a cell therapy?

Via Ella Buzhor
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Carlos Garcia Pando's curator insight, January 23, 2014 4:18 AM

Wherever Standartization appears it means there is going to be a widespread industrialization process, and that there are already strong stake holders wanting to have an advantaged position to start the race.

 

But this is good for the industry in general.

Christopher Duntsch's curator insight, January 25, 2014 10:24 AM

As a real world example, without naming the companies, at this time, there are two adult stem cell biotechnology companies that are very similar and of interest, pursuing the treatment of the same disease process and tissue anatomy. Company A is US based, and has the benefit of 8+ years of research, volumes of R&D and results / data, and all its data, IP, and outcomes, are documented, patented, and published. Company A has a more relevant / appropriate stem cell therapeutic, approach, and dose. Company A doses the tissue and disease process with 5 - 10*4 stem cells, and reports efficacy that ranges from 95% - 100%, and averages around 97% in all studies, and safety profiles that collectively considered to be near 100%. Conversely, company B is based in a very different geographic locale, and has fast tracked its R&D from literally announcing its intent, to entering clinical studies in less than 2 years. Company B has very little data to support its stem cell therapeutic, dosing, and approach. Company B doses the tissue and disease process with 5 x 10*7 cells (roughly 1000X higher than company A), and reports efficacy in some studies that is ~1-5%, and without detail admits in other studies no efficacy at all, and finally, reports a safety profile that is roughly 80 -90%. Company B is regulated in a very different area in the world and in a manner that is not rigorous, efficient, or consistent. Despite the dramatic differences between the two, company B continues to release financial reports, and press, that are positive and suggest present growth and real potential for growth going forward. Even more confusing, their valuation within the stock market they are publicly traded in, and public opinion of the company in general, by the public, current investors, and market analysts, remains stable, and at times even positive, and give the company a high valuation. These groups seem to be easily manipulated by efforts by the company to downplay negatives, explain away these results, and maintain a strong marketing front. I make the comparison here, to point out the relevance of my comments above for Pluristem Tx which similar in many respects to Company B, and to compare both to company A, US Biotec

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Stem Cell Universe with Stephen Hawking: TV show graphic and link

Stem Cell Universe with Stephen Hawking: TV show graphic and link | Stem-Cells | Scoop.it
Turns out the show on stem cells that I and some others in the stem cell field will be on with Stephen Hawking that is airing next Monday, February 3rd, on the Science Channel is called “Stem Cell Universe with Stephen Hawking” (scroll down in this...
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The scientific pursuit of eternal youth - Signals Blog

The scientific pursuit of eternal youth - Signals Blog | Stem-Cells | Scoop.it
A MUST-READ courtesy of the #WSCS13 Poster Forum runner-up & future leader in the field, Ben Paylor. http://t.co/NzrOg9k5nd
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Interview With Organizers of Tomorrow's Berkeley Stem Cell Meeting

Interview With Organizers of Tomorrow's Berkeley Stem Cell Meeting | Stem-Cells | Scoop.it
I'm really looking forward to this Saturday's Berkeley Stem Cell Meeting. You should go! Tickets are just $5 and the lineup is great. This looks to be one of the best stem cell meetings in Northern...
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Amazon.com: Stem Cells:An Insider's Guide eBook: Paul Knoepfler: Kindle Store

Stem Cells:An Insider's Guide - Kindle edition by Paul Knoepfler. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Stem Cells:An Insider's Guide.
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CIRM Creativity Student Long Nguyen Learns First-Hand about the Value of Scientific Research

CIRM Creativity Student Long Nguyen Learns First-Hand about the Value of Scientific Research | Stem-Cells | Scoop.it
This summer we’re sponsoring high school interns in stem cell labs throughout California as part of our annual Creativity Program. We asked those students to share their experiences through blog po...
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3D Microarray Platform for Toxicology Assays in Neural Development

3D Microarray Platform for Toxicology Assays in Neural Development | Stem-Cells | Scoop.it

In collaboration with Rensselaer Polytechnic Institute (RPI/USA), BERG researchers at the Stem Cell Bioengineering and Regenerative Medicine Laboratory (SCBL) have recently developed a 3D microarray platform to perform high-throughput studies of human Neural Stem Cell (hNSC) Differentiation and Toxicology. By using this platform it is possible to screen for the differential toxicity of small molecules to hNSCs which may help to predict, in vitro, which compounds pose an increased threat to neural development and should therefore be prioritized for further screening and evaluation. The work was published in “Stem Cell Research” journal. Click on title to learn more,


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3-D Printed Tissues Advance Stem Cell Research - Rensselaer Polytechnic Institute

3-D Printed Tissues Advance Stem Cell Research - Rensselaer Polytechnic Institute | Stem-Cells | Scoop.it
3-D Printed Tissues Advance Stem Cell Research
Rensselaer Polytechnic Institute
Dai will use the five-year, $440,000 grant to advance his research into bio-fabricating human tissues with 3-D cell printing technology.
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Reversing Autism in the Lab with Help from Stem Cells and the Tooth Fairy


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Jacob Blumenthal's curator insight, March 27, 2014 9:15 AM

In this talk, Alysson Muotri from UCSD talks about his research on Autism and how he uses stem cells to model the disease. A very interesting talk!

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Stem cell image contest: $100 & other great prizes

Stem cell image contest: $100 & other great prizes | Stem-Cells | Scoop.it
This blog is having a stem cell image contest.
Submit your favorite, original photomicrographs of stem cells.
Prizes include a $100 gift card, cool stem cell logo t-shirts (see at left), and signed copies of my book, Stem Cells: An Insider’s Guide.
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360 Stem Cell & Regenerative Medicine Newsletter- March 3, 2014

360 Stem Cell & Regenerative Medicine Newsletter- March 3, 2014 | Stem-Cells | Scoop.it
FROM China to North Carolina, Oklahoma to South Korea and all points in between, your global news source- our 360... http://t.co/0DHXYY6Z5Q
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We are hiring - Senior Sales Manager (USA)

Senior Sales Manager-located in the USA Send your C.V to jacobb@lifemapsc.com Job Description LifeMap Sciences, Inc., a subsidiary of BioTime, Inc. (NYSE: BT...

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Breakthrough in Stem Cell Research: The Derivation of Novel Human Ground-State Naive Pluripotent Stem Cells

Breakthrough in Stem Cell Research: The Derivation of Novel Human Ground-State Naive Pluripotent Stem Cells | Stem-Cells | Scoop.it

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Jacob Blumenthal's curator insight, February 2, 2014 1:26 AM

Formation of the naive epiblast in the mammalian embryo occurs several days after fertilization. The zygote initially undergoes division and after a fixed number of cell cycles, the inner blastomeres generate the inner cell mass (ICM), while those on the periphery begin to form the trophoblast. The resulting structure is called the blastocyst.
The ICM produces the hypoblast, a second extraembryonic lineage, and at approximately the same time, the inner cells develop into a pluripotent epiblast.
The epiblast constitutes the ground state, namely, a fully unrestricted pluripotent cell population that harbors the developmental potential and flexibility to produce all embryonic lineages. At this point, embryonic stem cells (ESCs), an immortalized representation of the naïve epiblast, can be derived.
Under appropriate conditions, ESCs exhibit an unlimited...

 

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Joe Riggs's comment, February 2, 2014 8:48 AM
Jacob, I am a big fan of naive pluripotency as technically superior to primed human pluripotent stem cells. i argue that the field will eventually settle here as the optimal growth conditions for increased efficiency in scale-up and stable propagation.<br><br>While having clonal advantage and decreased heterogeneity are benefits, the limitation may end up being the high cost of LIF. LIF as I have priced it is nearly 10x to fgf. Does anybody know why LIF is so expensive.<br><br>also, academic discussion on the benefit of naive vs primed pluripotent stem cells is encouraged as I'd like to know what you and others think about the benefits of naive pluripotency and should we move faster to establish and adopt these culture conditions.
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Stem cells and the transformative power of hope: Bernard Siegel at TEDxDelrayBeach - YouTube

Bernie was a courtroom attorney, and a cancer and Hurricane Andrew survivor. For fun, he owned a minor league basketball team and became commissioner of a pr...

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Jacob Blumenthal's curator insight, January 30, 2014 1:23 AM

A great and interesting talk!! Highly recommended!

 

Learn more about stem cells:

http://discovery.lifemapsc.com/stem-cell-differentiation

 

Join my Facebook group for more stem cell scoops:

https://www.facebook.com/groups/STEMCELLSNET/

 

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California Stem Cell Report: Jerry Brown: California Leads the Way on Stem Cell Research

California Stem Cell Report: Jerry Brown: California Leads the Way on Stem Cell Research | Stem-Cells | Scoop.it
Jerry Brown: California Leads the Way on Stem Cell Research: While he did not mention the stem cell agency by ... http://t.co/WL9AbT0P22
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LifeMap Discovery - Introduction - YouTube

LifeMap Discovery (http://discovery.lifemapsc.com) is a compendium of embryonic development, stem cell research and regenerative medicine, constructed by int...

Via Jacob Blumenthal
Joe Riggs's insight:

LifeMap Discovery is an unprecedented interactive user-friendly searchable database that provides comprehensive coverage of  stem cell research and developmental biology. Contains important protocols for differentiation, gene expression profiles, and more. The team at the Student Society for Stem Cell Research (SSSCR) is impressed by the educational potential of this platform and its significance for the research community.

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Jacob Blumenthal's curator insight, January 15, 2014 2:59 PM

View this introductory video on LifeMap Discovery database for the use of stem cell researchers, developmental biologists, and regenerative medicine experts!

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World Stem Cell Summit Poster Forum Prizes Sponsored by Stemedica - GlobeNewswire (press release)

World Stem Cell Summit Poster Forum Prizes Sponsored by Stemedica - GlobeNewswire (press release) | Stem-Cells | Scoop.it
World Stem Cell Summit Poster Forum Prizes Sponsored by Stemedica
GlobeNewswire (press release)
SAN DIEGO, CALIF., Oct.
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