Stem Cell Technology
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NEXT: The Brave New World of 3D Bioprinting

NEXT: The Brave New World of 3D Bioprinting | Stem Cell Technology | Scoop.it
“ Why wait for a liver transplant when soon you could use bioprinters to print a liver tissue from your own stem cells? 3D bioprinting will revolutionize the fields of stem cell research and tissue e...”
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For the first time, light sensitive retina was generated from stem cells

For the first time, light sensitive retina was generated from stem cells | Stem Cell Technology | Scoop.it
“ Researchers from the Johns Hopkins University School of Medicine have generated retina-like structures from induced pluripotent stem cells (iPSC). They modified an existing protocol (1,2,3) that wa...”
Via Jacob Blumenthal
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This is definitely an exciting and promising development in the field of stem cell engineering.
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New Mesenchymal Stem Cell Population from Human Pluripotent Stem Cells ... - Business Wire (press release)

New Mesenchymal Stem Cell Population from Human Pluripotent Stem Cells ... - Business Wire (press release) | Stem Cell Technology | Scoop.it
New Mesenchymal Stem Cell Population from Human Pluripotent Stem Cells ...
Business Wire (press release)
The research appears online ahead of print in Stem Cell and Development, one of the top stem cells journals, published by Mary Ann Liebert, Inc.
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This is promising. Stem cell company ACTC reports a population of MSCs derived from human PSCs with characterization of their immunomodulatory properties and in vivo potency.

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3-D printer creates transformative device for heart treatment that can keep a ... - Next Big Future

Next Big Future
3-D printer creates transformative device for heart treatment that can keep a ...
Next Big Future
... that has been kept beating outside of the body in a nutrient and oxygen-rich solution.
Mayasari's insight:

This is an exciting development for the biomedical industry. Tiny sensors are being printed on an elastic silicon membrane shaped in the form of the epicardium to allow physicians to monitor temperature, pH, and mechanical strain of the patient's heart. Alternatively such a device could also be used to deliver electrical signals to arrhythmic patients.

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Bioreactor engineering of stem cell environments

Bioreactor engineering of stem cell environments | Stem Cell Technology | Scoop.it

Stem cells hold promise to revolutionize modern medicine by the development of new therapies, disease models and drug screening systems. Standard cell culture systems have limited biological relevance because they do not recapitulate the complex 3-dimensional interactions and biophysical cues that characterize the in vivo environment. In this review, we discuss the current advances in engineering stem cell environments using novel biomaterials and bioreactor technologies. We also reflect on the challenges the field is currently facing with regard to the translation of stem cell based therapies into the clinic.


Via CYTOO
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This review covers the latest development in 3D stem cell cultures and bioreactor technology. Over the past decade, the shift in stem cell bioprocessing efforts has been toward recapitulating 3D microenvironment to provide better in vivo mimicry for cultivating stem cells in vitro. This review provides a nice summary of these efforts.

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Solvent-induced intelligent molecules

Solvent-induced intelligent molecules | Stem Cell Technology | Scoop.it

Intelligence is not only a matter of humans and animals. Scientists speak also of intelligent molecules. The latter directly react to external stimuli and change reversibly their shape. NIM physicists demonstrate the process for the first time with a single molecule.

 

Intelligent molecules could work in the future as nanoswitches: stimuli such as hot-cold, light-dark or altered salt concentrations can be toggled/switched back and forth between different conformations and thus act by itself as stimulus generator. Molecules with these abilities can be found in different groups of elements, but especially in proteins and synthetic polymers.

Until the real use of intelligent molecules, science must still learn about these compounds. The LMU physicists Dr. Michael Nash from the group of Prof. Hermann Gaub, a member of The Cluster of Excellence Nanosystems Initiative Munich (NIM), has now succeeded in making a reaction with a single polymer molecule visible for the first time. For this, Nash and his colleagues placed a self made synthesized polymer on a gold surface using an atomic force microscope (AFM). One polymer end adhered on the surface and the other end at the tip of the AFM. Once the scientists increased the salt concentration of the surrounding medium, they were able to observe how the molecule collapsed gradually.

 

"In a highly concentrated salt solution, the polymer compound dehydrates and shrinks," says Dr. Michael Nash, first author of the study. "Back in a weak salt solution, the molecule unfolds again. We have observed both processes in our study for the first time for a single polymer molecule”.

 

The new method of the biophysicists from Munich provides an important element for nanoswitches of the future and their potential use in biosensors, drugs, chromatography procedures and much more. The publication of the journal ACS Nano has been selected as Cover Article, in combination with a 3D graphic of the NIM-media designer.

 

REFERENCES:Michael A. Nash, and Hermann E. Gaub, Single-Molecule Adhesion of a Stimuli-Responsive Oligo(ethylene glycol) Copolymer to Gold, ACS Nano, 2012, DOI: 10.1021/nn303963m

 


Via Dr. Stefan Gruenwald
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Intelligent molecules are very cool and will definitely play an important role in the design of future biosensors for tracking many different aspects of the cell regulatory mechanisms.

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Induced pluripotent neural stem cells in screening assay

Induced pluripotent neural stem cells in screening assay | Stem Cell Technology | Scoop.it
“The study of neurodegenerative diseases has produced a number of interesting lead compounds but very few that become approved drugs. Over the years High Throughput Screening (HTS) has been used to ...”
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Asterias Biotherapeutics, Inc. Announces New Results From First-in-Man Clinical Trial of a Cell Therapy Derived From Embryonic Stem Cells | DNA RNA and Cells | News Channels

Asterias Biotherapeutics, Inc. Announces New Results From First-in-Man Clinical Trial of a Cell Therapy Derived From Embryonic Stem Cells | DNA RNA and Cells | News Channels | Stem Cell Technology | Scoop.it
“Asterias Biotherapeutics, Inc. Announces New Results From First-in-Man Clinical Trial of a Cell Therapy Derived From Embryonic Stem Cells (Remember Geron's SCI trial?”
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Stem cell scientist calls for retraction of study - DigitalJournal.com

Stem cell scientist calls for retraction of study - DigitalJournal.com | Stem Cell Technology | Scoop.it
DigitalJournal.com Stem cell scientist calls for retraction of study DigitalJournal.com In 2006, a team led by Shinya Yamanaka of Kyoto University, who was a co-recipient of the 2012 Nobel Prize for Medicine, created so-called induced pluripotent...
Mayasari's insight:

STAP (stimulus-triggered acquisition of pluripotency) cells has recently made headlines in the scientific and biomedical community. However recent allegations has questioned the validity of some of these findings and while investigations are still on-going, the Japanese team at RIKEN is considering to retract the data from their recently published Nature paper. More news to come regarding this matter. 

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Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Platelets from Human Induced Pluripotent Stem Cells http://t.co/vJuxbFOFhm
Mayasari's insight:

Functional platelets have significant clinical application. Use of human iPSCs to generate megakaryocyte cell lines via gene control is demonstrated in this article. The scalability of such protocols is important for determining its clinical utility. 

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GEN | Magazine Articles: Induced Pluripotent Stem Cells: A U.S. Patent Landscape Analysis

GEN | Magazine Articles: Induced Pluripotent Stem Cells: A U.S. Patent Landscape Analysis | Stem Cell Technology | Scoop.it
Find out which institutions are leading research and development in the creation and use of iPSCs. (Induced Pluripotent Stem Cells: A U.S.
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