Stem cell bioprocesing
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Skin Layer Grown from Stem Cells Could Replace Animal Testing - Bioscience Technology

Skin Layer Grown from Stem Cells Could Replace Animal Testing - Bioscience Technology | Stem cell bioprocesing | Scoop.it
Skin Layer Grown from Stem Cells Could Replace Animal Testing Bioscience Technology The new epidermis, grown from human pluripotent stem cells, offers a cost-effective alternative lab model for testing drugs and cosmetics, and could also help to...

Via Maureen Bunger
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This is an excellent in vitro application of iPSC derived cell sources which could be used to generate disease models of the skin. Authors were able to generate a 3D model and demonstrate its functionality as a permeability barrier. A direct link to this report is given below:

http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)00088-5.pdf

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Maureen Bunger's curator insight, April 29, 2014 2:53 PM

This article describes an advancement using iPSCs to grow keratinocytes for creating repeatable models of epidermis (the outer layer of skin).  While the article touts the development as an opportunity to end animal testing in cosmetics, I think another important application of this type of capability is modeling of skin diseases as well as potentially moving towards lab-grown skin grafts.  

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Key Tools and Technology Hurdles in Advancing Stem-Cell Therapies

Key Tools and Technology Hurdles in Advancing Stem-Cell Therapies | Stem cell bioprocesing | Scoop.it
“Roundtable convened by The California Institute for Regenerative Medicine (CIRM), the Alliance for Regenerative Medicine (ARM), and the Cell Therapy Catapult (Catapult).”
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Excellent guidance and insight on this topic
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Pluristem receives US FDA approval for manufacturing of PLX cell products - pharmabiz.com

Pluristem receives US FDA approval for manufacturing of PLX cell products - pharmabiz.com | Stem cell bioprocesing | Scoop.it
Pluristem receives US FDA approval for manufacturing of PLX cell products pharmabiz.com At its new state-of-the-art GMP manufacturing facility, Pluristem has implemented its proprietary, fully automated 3D cell expansion manufacturing platform that...
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Industry efforts in large scale expansion of stem cells are starting to advance, here is an example from Pluristem who is developing an automated 3D culture system.

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Current news at TAP Biosystems

Current news at TAP Biosystems | Stem cell bioprocesing | Scoop.it

TaFree webinar on mimicking perfusion #cellculture with micro#bioreactors. Click for dets http://t.co/0s8mosVgwj #lifescience #bioprocess

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TAP Biosystems will present their perfusion culture microbioreactor mimic at this upcoming webinar on March 12th.

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HESUB consortium will develop bioreactors for production of stem ...

The Electrospinning Company is a member of the HESUB consortium, which has been awarded €5.7 million over three years by the European Union 7th framework programme to develop a single-use bioreactor for the cost-effective ...
Mayasari's insight:

This is an exciting development in bioreactor technology that I would advocate. Perfusion  maintains the overall longevity of a healthy culture better than static cultures, as we have evidenced in our hollow fiber bioreactor studies. Cell attachment on nanofiber structures also aids in stem cell proliferation.

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What are the recent advances in Stem Cell culture?

What are the recent advances in Stem Cell culture? | Stem cell bioprocesing | Scoop.it
“During my daily discussions with researchers involved in in vitro iPS and Embryonic Stem cell cultures, I am always amazed by the passion that drives them. However, the more I go in depth with them...”
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Controlled delivery of growth factors via encapsulation
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NASA Bioreactors Advance Disease Treatments

NASA Bioreactors Advance Disease Treatments | Stem cell bioprocesing | Scoop.it
“Originating Technology/NASA Contribution The International Space Station (ISS) is falling. This is no threat to the astronauts onboard, however, because falling is part of the ISS staying in orbit....”
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Dendritic cells derived from pluripotent ... [World J Stem Cells. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Dendritic cells (DCs) are another class of immune cells with high clinical value. This review summarizes the recent efforts made by various groups to generate DCs in large amounts from human pluripotent stem cells. It further emphasizes the need for good bioprocessing strategies in order to produce DCs in large amounts, under well controlled conditions and economically. The use of bioreactors for these efforts are also discussed here.

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Journal of Biological Engineering | Full text | Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot ...

Journal of Biological Engineering | Full text | Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot ... | Stem cell bioprocesing | Scoop.it
Among disposable bioreactor systems, cylindrical orbitally shaken bioreactors show important advantages. They provide a well-defined hydrodynamic flow combined with excellent mixing and oxygen transfer for mammalian and plant cell cultivations. Since there is no known universal correlation between the volumetric mass transfer coefficient for oxygen kLa and relevant operating parameters in such bioreactor systems, the aim of this current study is to experimentally determine a universal kLa correlation.
Mayasari's insight:

The mass transfer coefficient kLa equation that is valid for cylindrical bioreactors from 2L to 200L was developed and reported in this paper.

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