STEAM
Follow
Find
409 views | +0 today
 
Rescooped by Anne Pascucci, MPA, CRA from Amazing Science
onto STEAM
Scoop.it!

Introducing the multi-tasking nanoparticle for diagnostic and therapeutic applications

Introducing the multi-tasking nanoparticle for diagnostic and therapeutic applications | STEAM | Scoop.it

Kit Lam and colleagues from UC Davis and other institutions have created dynamic nanoparticles (NPs) that could provide an arsenal of applications to diagnose and treat cancer. Built on an easy-to-make polymer, these particles can be used as contrast agents to light up tumors for MRI and PET scans or deliver chemo and other therapies to destroy tumors. In addition, the particles are biocompatible and have shown no toxicity. The study was published online today in Nature Communications.

 

“These are amazingly useful particles,” noted co-first author Yuanpei Li, a research faculty member in the Lam laboratory. “As a contrast agent, they make tumors easier to see on MRI and other scans. We can also use them as vehicles to deliver chemotherapy directly to tumors; apply light to make the nanoparticles release singlet oxygen (photodynamic therapy) or use a laser to heat them (photothermal therapy) – all proven ways to destroy tumors.”


Jessica Tucker, program director of Drug and Gene Delivery and Devices at the National Institute of Biomedical Imaging and Bioengineering, which is part of the National Institutes of Health, said the approach outlined in the study has the ability to combine both imaging and therapeutic applications in a single platform, which has been difficult to achieve, especially in an organic, and therefore biocompatible, vehicle.

 

"This is especially valuable in cancer treatment, where targeted treatment to tumor cells, and the reduction of lethal effects in normal cells, is so critical,” she added.

 

 Though not the first nanoparticles, these may be the most versatile. Other particles are good at some tasks but not others. Non-organic particles, such as quantum dots or gold-based materials, work well as diagnostic tools but have safety issues. Organic probes are biocompatible and can deliver drugs but lack imaging or phototherapy applications.


Built on a porphyrin/cholic acid polymer, the nanoparticles are simple to make and perform well in the body. Porphyrins are common organic compounds. Cholic acid is produced by the liver.


To further stabilize the particles, the researchers added the amino acid cysteine (creating CNPs), which prevents them from prematurely releasing their therapeutic payload when exposed to blood proteins and other barriers. At 32 nanometers, CNPs are ideally sized to penetrate tumors, accumulating among cancer cells while sparing healthy tissue.


In the study, the team tested the nanoparticles, both in vitro and in vivo, for a wide range of tasks. On the therapeutic side, CNPs effectively transported anti-cancer drugs, such as doxorubicin. Even when kept in blood for many hours, CNPs only released small amounts of the drug; however, when exposed to light or agents such as glutathione, they readily released their payloads. The ability to precisely control chemotherapy release inside tumors could greatly reduce toxicity. CNPs carrying doxorubicin provided excellent cancer control in animals, with minimal side effects.


Via Dr. Stefan Gruenwald
Anne Pascucci, MPA, CRA's insight:

Incredible!

more...
No comment yet.
Your new post is loading...
Your new post is loading...
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

CNU Board of Visitors approves funding for three new buildings - Daily Press

CNU Board of Visitors approves funding for three new buildings - Daily Press | STEAM | Scoop.it
Christopher Newport University 's Board of Visitors approved resolutions on Feb. 20 for debt issuance to expand dining facilities, construct residential housing and build residence hall VII on campus.
more...
No comment yet.
Rescooped by Anne Pascucci, MPA, CRA from Metaglossia: The Translation World
Scoop.it!

Destination Imagination: Area teams for regional tournament

Destination Imagination: Area teams for regional tournament | STEAM | Scoop.it
More than 20 local school teams and 150 students, including groups from Kingsport, Sullivan County and Johnson City, are scheduled to participate in the Destination Imagination Regional Tournament in Greene County.

Via Charles Tiayon
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Event introduces engineering and technology to girls - Quad City Times

Event introduces engineering and technology to girls - Quad City Times | STEAM | Scoop.it
Melaina Yender, 8, and her sister Lillian, 6, worked the blades of the small windmill at the Advanced Technology Environmental and Energy Center table inside the Rogalski Center at St.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Wareham STEAM students hold robot 'parade' - Wicked Local Wareham

Wareham STEAM students hold robot 'parade' - Wicked Local Wareham | STEAM | Scoop.it
WAREHAM – It may not have compared to a Veterans Day procession in Wareham or a New Year’s Day extravaganza in California, but a
more...
No comment yet.
Rescooped by Anne Pascucci, MPA, CRA from 21st Century School Libraries
Scoop.it!

Engineering game promotes problem solving, mechanical concepts | eSchool News | eSchool News

Engineering game promotes problem solving, mechanical concepts | eSchool News | eSchool News | STEAM | Scoop.it
A new engineering game helps students learn hard-to-master mechanical design concepts.

Via Bookmarking Librarian
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

We're Testing Children on the Wrong Things - New York Magazine

We're Testing Children on the Wrong Things - New York Magazine | STEAM | Scoop.it
Are we measuring what we want to measure in education?
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

U. Mass. Will Not Admit Iranian Students to Schools of Engineering and Natural Sciences

U. Mass. Will Not Admit Iranian Students to Schools of Engineering and Natural Sciences | STEAM | Scoop.it
U. Mass. Will Not Admit Iranian Students to Schools of Engineering and Natural Sciences http://t.co/OYX7uFm0Mn via @CoreyRobin
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

From STEM to STEAM to STREAM: wRiting as an Essential Component of Science Education

From STEM to STEAM to STREAM: wRiting as an Essential Component of Science Education | STEAM | Scoop.it
Writing mastery is essential to STEM learning and innovating.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

“All Eyes on IMLS”: Priorities for 2015 | ALA Midwinter 2015 - Library Journal

“All Eyes on IMLS”: Priorities for 2015 | ALA Midwinter 2015 - Library Journal | STEAM | Scoop.it
Eager to promote strategic priorities for 2015, officials for the Institute of Museum and Library Services (IMLS) trained a spotlight on the various federal funding resources available through the Library Services and Technology Act (LSTA) during a...
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Mathematics and Arts, as Critical components of a Civilization : Hyung ju Park at TEDxDaedeokValley - Videos Online

Mathematics and Arts, as Critical components of a Civilization : Hyung ju Park at TEDxDaedeokValley - Videos Online | STEAM | Scoop.it
Hyung ju Park was studying physics as an undergraduate at Seoul National University when he discovered the beauty of Evasite Galois's group theory.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Opening day highlights at the Big Sky Documentary Film Festival - Ravalli Republic

Opening day highlights at the Big Sky Documentary Film Festival - Ravalli Republic | STEAM | Scoop.it
Each day, watch for highlights from the Big Sky Documentary Film Festival. Starting Saturday, these highlights will run in the Montana section of the Missoulian.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Science, Technology, Engineering, Arts and Mathematics (STEAM) Share Fair open to community March 7 - College of Education | University of South Carolina

Science, Technology, Engineering, Arts and Mathematics (STEAM) Share Fair open to community March 7 - College of Education | University of South Carolina | STEAM | Scoop.it
All community members are invited to Share Fair Nation, a day of free, interactive science, technology, engineering, arts and mathematics (STEAM) learning and fun March 7 at River Bluff High School in Columbia, SC.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Camps for the Kid Who Loves Science, Tech, Engineering, Math - ABC News

Camps for the Kid Who Loves Science, Tech, Engineering, Math - ABC News | STEAM | Scoop.it
For kids whose dream summer camp involves more coding than canoeing, more technology than tennis and more science than swimming, STEM summer camps — once considered a contradiction in terms — are popular and plentiful.
Anne Pascucci, MPA, CRA's insight:

Best line in the article is "fun of thinking"!!

more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

You are here - Rensselaer Polytechnic Institute

You are here - Rensselaer Polytechnic Institute | STEAM | Scoop.it
You are here
Rensselaer Polytechnic Institute
“We are always looking for ways to engage with students and the local community to encourage individuals to explore science, technology, engineering, and mathematics (STEM) disciplines.
Anne Pascucci, MPA, CRA's insight:

Only one day a year?  RPI still rocks

more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

NMSU attracts hundreds of high school kids 'energized about engineering' - Las Cruces Sun-News

NMSU attracts hundreds of high school kids 'energized about engineering' - Las Cruces Sun-News | STEAM | Scoop.it
LAS CRUCES >> About 500 high school students from across New Mexico converged on New Mexico State University and received a taste of college life on Tuesday.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Leading Mobility Innovation Sparks Collaboration Among Global Engineering Community

Leading Mobility Innovation Sparks Collaboration Among Global Engineering Community | STEAM | Scoop.it
Under the theme Leading Mobility Innovation, Honda is honored to serve as the Host Company of the Society of Automotive Engineers' (SAE) 2015 World Congress & Exhibition, April 21-23 at Cobo Ha...
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Science museum catapults children into engineering fun - Roanoke Times

Science museum catapults children into engineering fun - Roanoke Times | STEAM | Scoop.it
The latest news headlines for Roanoke VA news from The Roanoke Times
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

[UPDATED] A University Reversed Its Ban on Iranian Students After Outrage

[UPDATED] A University Reversed Its Ban on Iranian Students After Outrage | STEAM | Scoop.it
Students said they felt "betrayed, excluded, and threatened."
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Rethink Different Learners Blog

In Adam Man's most recent blog post, he examines STEAM
(Science, Technology, Engineering, Arts and Mathematics).... http://t.co/sgy70l4lNv
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Full STEAM Ahead: Inside Penn's Approach to Education - The Daily Pennsylvanian

Full STEAM Ahead: Inside Penn's Approach to Education - The Daily Pennsylvanian | STEAM | Scoop.it
Is emphasizing everything the same as emphasizing nothing? Penn’s choice of a STEAM approach to education  — instead of a STEM approach — has raised this question.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Hipolito hired to guide STEAM curriculum at St. Helena Catholic School - Napa Valley Register

Hipolito hired to guide STEAM curriculum at St. Helena Catholic School - Napa Valley Register | STEAM | Scoop.it
St. Helena Catholic School has hired Jay Hipolito as a new faculty member to guide the STEAM (Science, Technology, Engineering, Arts and Mathematics) enrichment program and curriculum for the school.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

The Fascinating Engineering Details of the Titanic From a 1909 Journal 

The Fascinating Engineering Details of the Titanic From a 1909 Journal  | STEAM | Scoop.it
It's over 100 years since the Titanic final, fateful journey.
Anne Pascucci, MPA, CRA's insight:

What stories these journals can tell...

more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Re-creating a tornado in 3-D provides a more effective way to study storms - Phys.Org

Re-creating a tornado in 3-D provides a more effective way to study storms - Phys.Org | STEAM | Scoop.it
When The Weather Channel meteorologist Jim Cantore stepped into an EF-5 tornado re-created in 3-D in a four-story immersive installation at Virginia Tech, his perspective was that of someone 7,000 feet tall.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Bringing art and technology together - Ames Tribune

Bringing art and technology together - Ames Tribune | STEAM | Scoop.it
Tibi Chelcea wants us to step back and note how much technology is a part of our daily lives.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Destination Imagination combines creativity and community service - The Breeze

Destination Imagination combines creativity and community service - The Breeze | STEAM | Scoop.it
It’s common knowledge that finding electives and classes that count for each major can be a challenge. However, one class is offered as an elective for all 71 degree programs.
more...
No comment yet.