STEAM
Follow
Find
459 views | +0 today
 
Rescooped by Anne Pascucci, MPA, CRA from Amazing Science
onto STEAM
Scoop.it!

Sending Red Light Through The Skull To Influence Brain Activity Using Red-Shifted Cruxhalorhodopsin named Jaws

Sending Red Light Through The Skull To Influence Brain Activity Using Red-Shifted Cruxhalorhodopsin named Jaws | STEAM | Scoop.it
Genetically engineered protein responds remotely to red light.

 

A team of biological engineers has developed a light-sensitive protein that permits scientists to control activity inside the brains of mice from outside the rodents’ skulls. The protein, called Jaws, promises to expand scientists’ ability to study brain activity in experimental animals and -- eventually -- humans. Ultimately, it holds the prospect of facilitating treatment of human conditions such as epilepsy.


Researchers are also using the protein to treat eye disease in experimental animals. Here, an immediate goal is therapy for certain eye ailments in humans.


Scientists use optogenetics, as the technology is known, to study the behavior and pathology of experimental animals’ brains by shining light on proteins known as opsins. Introduced into the brain aboard viruses, the opsins respond to the light by suppressing or stimulating electrical signals in brain cells. Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. The red-shifted cruxhalorhodopsin, Jaws, derived from Haloarcula (Halobacterium) salinarum (strain Shark) and engineered to result in red light–induced photocurrents three times those of earlier silencers. Jaws exhibits robust inhibition of sensory-evoked neural activity in the cortex and results in strong light responses when used in retinas of retinitis pigmentosa model mice.


The opsins normally used in brain studies are sensitive to blue, green, or yellow light. Because bodily tissue absorbs those colors easily, the sources of such light must lie inside the brain. Typically, the light is delivered through an optical fiber implanted in an experimental animal’s brain. Jaws can noninvasively mediate transcranial optical inhibition of neurons deep in the brains of awake mice. The noninvasive optogenetic inhibition opened up by Jaws enables a variety of important neuroscience experiments and offers a powerful general-use chloride pump for basic and applied neuroscience.


A team led by Ed Boyden, associate professor of biological engineering and brain and cognitive sciences at the Massachusetts Institute of Technology, in Cambridge, reporting in Nature Neuroscience, demonstrated that red light shone from outside a mouse’s head can influence the Jaws protein up to three millimeters deep inside the brain. In fact, Boyden said, "we think the light goes further into the brain." A mouse’s brain is only about four millimeters thick.


"This is a huge advance, in that it allows for much deeper penetration of effective light," said David Lyon, an associate professor of anatomy and neurobiology at the University of California, Irvine School of Medicine. Lyon was not involved in the research on Jaws.


Via Dr. Stefan Gruenwald
Anne Pascucci, MPA, CRA's insight:

Wow

more...

From around the web

Your new post is loading...
Your new post is loading...
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

School districts move full STEAM ahead with grants - Observer-Reporter

School districts move full STEAM ahead with grants - Observer-Reporter | STEAM | Scoop.it
School districts move full STEAM ahead with grants Observer-Reporter School districts in Washington and Greene counties will be creating programs to get students involved in the fields of science, technology, engineering, the arts and mathematics,...
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

URI engineering student from Taunton helps design a smart wristband to monitor Parkinson’s

URI engineering student from Taunton helps design a smart wristband to monitor Parkinson’s | STEAM | Scoop.it
SOUTH KINGSTOWN, Rhode Island — For the four million people worldwide with Parkinson’s disease, a smart wristband invented by a team of
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

VH1 Save the Music to Live-Stream 'STEAM Education' Town Hall on May 7 ... - Billboard

VH1 Save the Music to Live-Stream 'STEAM Education' Town Hall on May 7 ... - Billboard | STEAM | Scoop.it
Grammy nominee Kenny Lattimore, Heroes star Masi Oka and Sesame Workshop SVP Rosemarie Truglio will be part of a town-hall discussion for VH1's Save The Music Foundation, scheduled to be live-streamed from New York’s Paley Center on Thursday, May...
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Engineers develop breathalyser to detect lung cancer

Engineers develop breathalyser to detect lung cancer | STEAM | Scoop.it
Engineers develop breathalyser to detect lung cancer #noninvasive #health #medtech http://t.co/TMQiEXfZkb http://t.co/ZwqMCdNTOb
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

China shocks world by genetically engineering human embryos

China shocks world by genetically engineering human embryos | STEAM | Scoop.it

YCritics warned that China was becoming the ‘Wild West’ of genetic research

Anne Pascucci, MPA, CRA's insight:

Yikes

more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Third-year Engineering students host STEM showcase for middle, high school ... - University of Virginia The Cavalier Daily

Third-year Engineering students host STEM showcase for middle, high school ... - University of Virginia The Cavalier Daily | STEAM | Scoop.it
Third-year Engineering students Grace Wusk and Trisha Hajela hosted over 50 middle and high school women at an event entitled “Ladies in the Lab” Sunday.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

$900000 to STEAM in grants - New Pittsburgh Courier

$900000 to STEAM in grants - New Pittsburgh Courier | STEAM | Scoop.it
Grants totaling nearly $900,000 from the Grable Foundation and the Fund for Excellence, have been awarded to bring STEAM programming to Pittsburgh Public Schools. STEAM (Science, Technology, Engine...
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Listen by numbers: music and maths

Listen by numbers: music and maths | STEAM | Scoop.it
Who says maths is all cold logic and music all emotion? That's nonsense, writes Marcus du Sautoy – the two are intimately connected
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

What Letter Should We Add to STEM?

What Letter Should We Add to STEM? | STEAM | Scoop.it
"An education devoid of arts is an empty, half-brain kind of education."
Anne Pascucci, MPA, CRA's insight:

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

more...
No comment yet.
Rescooped by Anne Pascucci, MPA, CRA from Sustain Our Earth
Scoop.it!

Plastic Bags Cut Wildlife Populations In Marshland Ecosystems | Chemical & Engineering News

Plastic Bags Cut Wildlife Populations In Marshland Ecosystems | Chemical & Engineering News | STEAM | Scoop.it

Via SustainOurEarth
more...
No comment yet.
Rescooped by Anne Pascucci, MPA, CRA from Professional Learning for Busy Educators
Scoop.it!

A Beautiful Visual on The Impact of Music Education on Kids Cognitive Skills

A Beautiful Visual on The Impact of Music Education on Kids Cognitive Skills | STEAM | Scoop.it

"Does music  education really improve kids cognitive skills? The answer, in our view, is hard to determine and it requires a series of longitudinal studies across different cultural and ethnic groups. However, certain small-scale studies such as the ones cited in the visual below do provide a preliminary evidence in favour of the correlation between taking music lessons and improvement in certain cognitive skills. For instance, in a study of 96 children aged 5-7 years old, those who received 7 months of supplementary music and arts classes earned higher mathematics scores than those with the schools’ typical music and arts training. In another collection of studies that involved a larger base of participants from high schools, researchers were able to identify a strong correlation between music instruction and higher reading test scores."


Via John Evans
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

A festival devoted to the math of everyday life - Washington Post

A festival devoted to the math of everyday life - Washington Post | STEAM | Scoop.it
Lectures, demonstrations and games featured at the National Math Festival on April 18
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Arizona State University Biodesign Institute Researchers Use New Technique to ... - Pulmonary Fibrosis News

Arizona State University Biodesign Institute Researchers Use New Technique to ... - Pulmonary Fibrosis News | STEAM | Scoop.it
Read about how Arizona Statue University Biodesign Institute researchers use tissue engineering to grow new lungs in lab.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Students extinguish fire with bass sound - CNN.com

Students extinguish fire with bass sound - CNN.com | STEAM | Scoop.it
Boom-bass out da flames! Firefighters may be snuffing blazes with deep-toned sound, if a new device invented by two engineering students catches on.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Engineering a better solar cell: UW research pinpoints defects in popular ... - UW Today

Engineering a better solar cell: UW research pinpoints defects in popular ... - UW Today | STEAM | Scoop.it
UW Today
Engineering a better solar cell: UW research pinpoints defects in popular ...
UW Today
One of the fastest-growing areas of solar energy research is with materials called perovskites.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

HPS board of trustees to vote on 6th grade academy proposal - WDAM-TV

HPS board of trustees to vote on 6th grade academy proposal - WDAM-TV | STEAM | Scoop.it
Next Monday the Hattiesburg Public Schools board of trustees will be presented with the proposal of a 6th Grade S.T.E.A.M. Academy within the district.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Mathematics in motion a winning formula from Peggy Baker

Mathematics in motion a winning formula from Peggy Baker | STEAM | Scoop.it
Baker explained that locus plot, her first full-evening ensemble piece, was inspired by pictorial images of mathematical equations that she found online
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Explore Resources for Women Undergrads Interested in Science, Engineering - U.S. News & World Report

Explore Resources for Women Undergrads Interested in Science, Engineering - U.S. News & World Report | STEAM | Scoop.it
The percentage of women earning bachelor's degrees in science and engineering has decreased, one report states.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Meet the 2015 Mass Media Fellows! | AAAS - The World's Largest General Scientific Society

RT @elenelse: Here are the new @AAASMassMedia fellows! Congratulations!! http://t.co/sOfTZ53A7z
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Meet the Robot That Could One Day Cook Your Meals > ENGINEERING.com

Meet the Robot That Could One Day Cook Your Meals > ENGINEERING.com | STEAM | Scoop.it
Moley Robotics is developing a dexterous robot equipped with an iTunes-style recipe library boasting more than 2,000 dishes.
Anne Pascucci, MPA, CRA's insight:

Need all the help I can get!

more...
No comment yet.
Rescooped by Anne Pascucci, MPA, CRA from Metaglossia: The Translation World
Scoop.it!

In our opinion: Liberal arts vs STEM education: Technology may improve, but creativity is always necessary

In our opinion: Liberal arts vs STEM education: Technology may improve, but creativity is always necessary | STEAM | Scoop.it
STEM programs are critically important as technology provides ever more efficient ways to deliver what customers demand.

Via Charles Tiayon
more...
Robin Jeffery's curator insight, April 21, 8:53 PM

Creative minds have shaped human history. Without creative minds imagining a brighter future we may become trapped by routine and convention.

Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

UCSD Extension, UCTV Launch The STEAM Channel - Times of San Diego

UCSD Extension, UCTV Launch The STEAM Channel - Times of San Diego | STEAM | Scoop.it
UCSD Extension, UCTV launch The STEAM Channel in response to the demand for professionals who can balance science, technology, engineering and mathematics.
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Arduino Robocars in the STEAM program-Spring 2015

Science, Technology, Engineering, Arts and Mathematics program. Students from 6th-8th grades from several Arizona Schools built, programmed and decorated ...
more...
No comment yet.
Scooped by Anne Pascucci, MPA, CRA
Scoop.it!

Liberal arts teach critical thought - Baltimore Sun

Liberal arts teach critical thought - Baltimore Sun | STEAM | Scoop.it
Liberal arts schools are enduring an unrelenting attack in the public media. Critics of higher education rail against the excessive cost of a college education and the high rate of student debt and default.
more...
No comment yet.