What does the research say about using cholinesterase inhibitors or memantine to improve cognition or function?
This is the Medscape Psychiatry Minute. I'm Dr. Peter Yellowlees. Cognitive enhancers, including cholinesterase inhibitors and memantine, are used to treat dementia, but their effectiveness for mild cognitive impairment is unclear. Now a team of investigators from Toronto, Canada, have conducted a systematic review to examine the efficacy and safety of cognitive enhancers for mild cognitive impairment. The investigators screened 15,554 titles and abstracts and 1384 full-text articles for studies of the effects of donepezil, rivastigmine, galantamine, or memantine on mild cognitive impairment. From this extensive literature, only 8 randomized clinical trials and 3 companion reports met inclusion criteria. In these studies, the investigators found no significant effects of cognitive enhancers on cognition or function. Cognitive enhancers were associated with higher risks for nausea, diarrhea, and vomiting than placebo. Although much more research is needed into the overall value of cognitive enhancers, the findings from this study do not support their use in patients with mild cognitive impairment. This article is selected from Medscape Best Evidence. I'm Dr. Peter Yellowlees.
Researchers using information provided by a magnetic resonance imaging (MRI) technique have identified regional white matter damage in the brains of people who experience chronic dizziness and other symptoms after concussion.
(Medical Xpress)—Schizophrenia is a severe disease for which there is still no effective medical treatment. In an attempt to understand exactly what happens in the brain of a schizophrenic person, researchers from the University of Southern Denmark have analyzed proteins in the brains of rats that ...
The first of a series of roundtables around the topic of Empathy.
Recorded July, 2013 at the Massachusetts Historical Society's Dowse Library. Featuring: Dr. Marco Iacoboni Dr. Mary Hellen Immordino-Yang Dr. Robert Weller Dr. Adam Seligman Leslie Jamison Ben Doepke & the SEEK company (host)
Carrying a copy of a gene variant called ApoE4 confers a substantially greater risk for Alzheimer's disease on women than it does on men, according to a new study by researchers at the Stanford University School of Medicine.
Ron Gutman reviews a raft of studies about smiling, and reveals some surprising results. Did you know your smile can be a predictor of how long you'll live -- and that a simple smile has a measurable effect on your overall well-being? Prepare to flex a few facial muscles as you learn more about this evolutionarily contagious behavior.
Scientists at the Gladstone Institutes have deciphered how a protein called Arc regulates the activity of neurons – providing much-needed clues into the brain’s ability to form long-lasting memories.
These findings, reported Sunday in Nature Neuroscience, also offer newfound understanding as to what goes on at the molecular level when this process becomes disrupted.
Led by Gladstone senior investigator Steve Finkbeiner, MD, PhD, this research delved deep into the inner workings of synapses. Synapses are the highly specialized junctions that process and transmit information between neurons. Most of the synapses our brain will ever have are formed during early brain development, but throughout our lifetimes these synapses can be made, broken and strengthened. Synapses that are more active become stronger, a process that is essential for forming new memories.