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Rescooped by Jocelyn Stoller from Neuroscience_topics
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GABA actions and ionic plasticity in epilepsy

GABA actions and ionic plasticity in epilepsy | Social Neuroscience Advances | Scoop.it

[Review] Highlights:- Ionic plasticity of GABA signaling relies on short-term and long term changes in EGABA-  Cl− transport and carboanhydrases play a key role in ionic plasticity and epilepsy.

- GABAergic transmission has both seizure-suppressing and seizure-promoting effects.

- TrkB and calpain act on GABA signaling to coordinate the process of epileptogenesis.

- GABA signaling has context-specific and age-specific effects in health and disease.

- by Kaila Kai et al., Current Opinion in Neurobiology, Volume 26, June 2014, Pages 34–41


Via Julien Hering, PhD
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Rescooped by Jocelyn Stoller from Neuroscience_topics
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Kv7 channels as targets for anti-epileptic and psychiatric drug-development

Kv7 channels as targets for anti-epileptic and psychiatric drug-development | Social Neuroscience Advances | Scoop.it

The Kv7 channels, a family of voltage-dependent K+ channels (Kv7.1–Kv7.5), have gained much attention in drug discovery especially because four members are genetically linked to diseases. For disorders of the CNS focus was originally on epilepsy and pain, but it is becoming increasingly evident that Kv7 channels can also be valid targets for psychiatric disorders, such as anxiety and mania. The common denominator is probably neuronal hyperexcitability in different brain areas, which can be successfully attenuated by pharmacological increment of Kv7 channel activity. This perspective attempts to review the current status and challenges for CNS drug discovery based on Kv7 channels as targets for neurological and psychiatric indications with special focus on selectivity and mode-of-actions. - by Grunnet M. et al., European Journal of Pharmacology, Volume 726, 5 March 2014, Pages 133–137


Via Julien Hering, PhD
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