[Review] Highlights:- Ionic plasticity of GABA signaling relies on short-term and long term changes in EGABA- Cl− transport and carboanhydrases play a key role in ionic plasticity and epilepsy.
- GABAergic transmission has both seizure-suppressing and seizure-promoting effects.
- TrkB and calpain act on GABA signaling to coordinate the process of epileptogenesis.
- GABA signaling has context-specific and age-specific effects in health and disease.
- by Kaila Kai et al., Current Opinion in Neurobiology, Volume 26, June 2014, Pages 34–41
Via Julien Hering, PhD