Shaping the Future of Medical Technology
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Organ-on-a-chip producer collaborates with Sanofi in medtech-pharma mashup

Organ-on-a-chip producer collaborates with Sanofi in medtech-pharma mashup | Shaping the Future of Medical Technology | Scoop.it
To evaluate ways to reduce drug research and development costs, Sanofi US is collaborating with organ-on-a-chip developer Hurel Corp. to assess drugs' effect on humans.
Monika McDole-Russell's insight:

More progress towards the development of organ-on-a-chip technology. I look forward to the outcome of this collaboration.

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IT's curator insight, December 16, 2013 8:01 AM

Není na to mít lékarnu ve vlastním těle.

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Topically applied curcumin nanoparticles alleviates joint pain and slows progression of Osteoarthritis

Topically applied curcumin nanoparticles alleviates joint pain and slows progression of Osteoarthritis | Shaping the Future of Medical Technology | Scoop.it
Researchers have shown, using a mouse model of osteoarthritis, that curcumin loaded nanoparticles topically applied to arthritic knees stopped the progression of the disease and eliminated associated pain by locally delivering curcumin to the fat pad associated with the knee cap. The study also demonstrated several osteoarthritis relevant inflammatory pathways were suppressed by curcumin, including those that result in the production of proteins that destroy cartilage.
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Biopen Used to Deposit Stem Cells, Repair Tissue Within Joints 

Biopen Used to Deposit Stem Cells, Repair Tissue Within Joints  | Shaping the Future of Medical Technology | Scoop.it

Stem cells have the capacity to be used to reconstruct and repair native tissues, but to apply them so that they survive and live on in their new home can be quite challenging. Now researchers at the Australian Research Council Centre of Excellence for Electromaterials Science have developed a “biopen” that can deposit stem cells wherever needed.

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3D Printed Bone Replacements Made Using Natural Bone and Plastic |

3D Printed Bone Replacements Made Using Natural Bone and Plastic | | Shaping the Future of Medical Technology | Scoop.it

At Johns Hopkins University researchers have created a recipe for making material that can be used to 3D print new bones. Unlike most previous attempts at making the stuff completely from man-made products, the new material consists of 30% pulverized decellularized natural bone mixed with polycaprolactone, a biodegradable polyester.

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ADME Toxicology - 3-D Lifelike Liver Tissue for Drug Screening

A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
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Forget Insulin Injections: New Patches Integrate Pancreatic Beta Cells to Control Blood Glucose |

Forget Insulin Injections: New Patches Integrate Pancreatic Beta Cells to Control Blood Glucose | | Shaping the Future of Medical Technology | Scoop.it
At the  University of North Carolina at Chapel Hill and North Carolina State University researchers may be fundamentally changing how insulin is delivered to help treat diabetes.
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Scaling up tissue engineering : Wyss Institute at Harvard

A team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells.
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Novel device measures stiffness and stickiness of red blood cells

Researchers have created a versatile device that measures two important properties of red blood cells that are relevant for sickle cell and other diseases: deformation and adhesion.

The team, from Case Western Reserve University (CWRU) in Cleveland, OH, describes the innovative device - a microfluidic platform with a computer algorithm that does the math - in a paper published in the journal Technology.
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Microfluidic Chip Mimics Smallest Capillaries to Study How Drugs Affect the Mechanics of Cells |

Microfluidic Chip Mimics Smallest Capillaries to Study How Drugs Affect the Mechanics of Cells | | Shaping the Future of Medical Technology | Scoop.it
Researchers from Georgia Tech and Emory University have decided to investigate whether physical processes may be at play, and so they built a microfluidic model blood vessel system that can replicate the forces experienced by white blood cells in the smallest of capillaries within our bodies.
Monika McDole-Russell's insight:

Yet another innovative use of microfluidic technology; not an organ-on-a chip this time, but a blood vessel-on-a-chip!

 

I first heard of the development of vessel chips at the OAC World Congress in Boston in July 2015 - it's very exciting to see a similar technology functional and in use by researchers less than one year later.

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Engineered Kidney-like Tissue with Possible Therapeutic Applications and Novel Drug Screening Platform |

Engineered Kidney-like Tissue with Possible Therapeutic Applications and Novel Drug Screening Platform | | Shaping the Future of Medical Technology | Scoop.it

Engineering of new organs (i.e. artificial organogenesis) from pluripotent stem cells represents the holy grail of modern medicine. 

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Lab-on-a-Disc Device Detects Urinary Tract Infections in About an Hour | Medgadget

Lab-on-a-Disc Device Detects Urinary Tract Infections in About an Hour | Medgadget | Shaping the Future of Medical Technology | Scoop.it

UTIs are a common occurrence in hospitalized patients with catheters, but they're typically detected too late and can lead to sepsis. Researchers from Ireland and Germany have now created a “Lab-on-a-Disc” device that can separate and detect bacteria in tiny samples of urine. 

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3D Printed Brain Regions Help Neurosurgeons Prepare for Difficult Procedures | Medgadget

3D Printed Brain Regions Help Neurosurgeons Prepare for Difficult Procedures | Medgadget | Shaping the Future of Medical Technology | Scoop.it
While neurosurgeons have been able to virtually navigate volumetric images of patients’ brain structures gathered from CT and MRI scans, difficult procedures within complex anatomy still remains challenging. At Boston Children’s Hospital, physicians are now using 3D-printed replicas of brain regions they’ll be working on to practice with before actual surgery.
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Injectable Hydrogel Material Serves as Scaffold to Heal Wounds

Injectable Hydrogel Material Serves as Scaffold to Heal Wounds | Shaping the Future of Medical Technology | Scoop.it
At UCLA researchers have designed an injectable hydrogel scaffold that promotes wound healing by serving as a 3D platform within which new tissue can grow.
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Printing Nerve Tissue in 3D Using Polymers and Graphene

Printing Nerve Tissue in 3D Using Polymers and Graphene | Shaping the Future of Medical Technology | Scoop.it

Researchers at Michigan Technological University are working on building replacement nerves using 3D bioprinting techniques. Even though still in the early stages, the team has already developed polymer materials that can serve as a scaffold for growing tissues and is working on integrating graphene as the electrical conductor. The combination of the materials can lead to the assembly of functional, high complexity nerve tissue that would then be transplanted into patients.

 

 

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Researchers Develop Dissolvable Electronic Brain Implants |

Researchers Develop Dissolvable Electronic Brain Implants | | Shaping the Future of Medical Technology | Scoop.it

Researchers at the Perelman School of Medicine at University of Pennsylvania and University of Illinois at Urbana-Champaign have reported in journal Nature Materials on a new type of intracranial electrodes that are able to dissolve and wash out of the body once done doing their job.

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New Class of Drug Ferrying Nanoparticles May Overcome Limitations of Existing Systems 

New Class of Drug Ferrying Nanoparticles May Overcome Limitations of Existing Systems  | Shaping the Future of Medical Technology | Scoop.it

Russian scientists at the Lomonosov Moscow State University are reporting the development of new drug ferrying nano-capsules that work fundamentally differently than existing nanoparticles. Each capsule consists of two concentric polymer shells that swell at different temperatures. The outer shell protects the capsule and also prevents the capsules from sticking to one another when they’re releasing their cargo, a problem that has confounded researchers for a while.

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Microparticles Use Only Magnetic Fields for Navigation, Release of Therapeutics |

Microparticles Use Only Magnetic Fields for Navigation, Release of Therapeutics | | Shaping the Future of Medical Technology | Scoop.it

Researchers at ETH Zurich in Switzerland have reported in the journal Materials Horizons on new microparticles that use an external magnetic field for propulsion and guidance while being able to generate a local electric field from changes in the external magnetic field. This electric field is then used to release a drug, imaging agent, or some other compound stored within the particle’s interior.

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Automation & Microfluidics - The Online Scientific Community - News

Researchers at U of T Engineering have developed a new way of growing realistic human tissues outside the body. Their “person-on-a-chip” technology, called AngioChip, is a powerful platform for discovering and testing new drugs, and could eventually be used to repair or replace damaged organs.

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Cyborg Heart Patch Replaces Dead Cardiac Tissue with Combination of Healthy Cells, Electronics |

Cyborg Heart Patch Replaces Dead Cardiac Tissue with Combination of Healthy Cells, Electronics | | Shaping the Future of Medical Technology | Scoop.it
Scientists at Tel Aviv University in Israel have developed a "cyborg heart patch" for replacing injured cardiac tissue. 
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3D Bioprinter for Making Life-Sized Constructs with Living Cells |

3D Bioprinter for Making Life-Sized Constructs with Living Cells | | Shaping the Future of Medical Technology | Scoop.it
In a new first, researchers from Wake Forest Institute for Regenerative Medicine have developed a 3D printing system that can print live cells into human-scale constructs representing bone, muscle, and ear tissue. 
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1.6 million dollar industry funding for neurotoxicity models | MIMETAS - The Organ on a Chip Company

1.6 million dollar industry funding for neurotoxicity models | MIMETAS - The Organ on a Chip Company | Shaping the Future of Medical Technology | Scoop.it
Mimetas has received 1.6 million USD funding for development of an organ-on-a-chip model for neurotoxicity. The aim of the project is to improve existing neurotoxicity tests and to reduce experimentation on animals.
Monika McDole-Russell's insight:

Although I don't often post company-specific articles, I felt this was worth sharing because of the potential this represents to take a giant step forward in developing more accurate, relevant neurotoxicity testing models.

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From Automation & Microfluidics: Penn Engineering Team Showcases ‘Eye-on-a-Chip’ Technology

A team of graduate students from the School of Engineering and Applied Science were among seven finalists at the Collegiate Inventors Competition earlier this week. Cassidy Blundell, Nicholas Perkons, and Jeongyun Seo presented their “eye-on-a-chip” to a team of experts from industry and academia, making the case that their device represents a more reliable, accurate, and ethical alternative to animal testing.
Monika McDole-Russell's insight:

An eye-on-a-chip is one step further than even I (a long-time OAC supporter) thought the technology could go. So glad to see these devices extending into new, innovative areas!

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3D Printed Microscopic Microfish to Swim Through Blood Delivering Drugs, Clean Up Toxins | Medgadget

3D Printed Microscopic Microfish to Swim Through Blood Delivering Drugs, Clean Up Toxins | Medgadget | Shaping the Future of Medical Technology | Scoop.it
At the University of California, San Diego, researchers have 3D printed tiny “microfish” that have propulsion mechanism, navigation, and even detoxification capabilities that may allow them to swim through blood and maybe even deliver targeted drug therapy.
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Silk Scaffold to Push Long Microneedles Deep Into Brain Tissue | Medgadget

Silk Scaffold to Push Long Microneedles Deep Into Brain Tissue | Medgadget | Shaping the Future of Medical Technology | Scoop.it
Today’s brain interfaces that sense electrical activity and deliver chemical compounds tend to be rigid devices based on microneedles that can’t penetrate very deep without destroying tissue on the way. The needles are hard and so can only work on the outside periphery of the brain. Researchers at Toyohashi University of Technology in Japan have taken an interesting approach to overcome this problem by creating very thin needles that can behave as rigid when entering tissue but become soft once inside, allowing them penetrate deeper without causing much damage.
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Lab-on-a-Chip Simulates Heartbeat for Testing New Drug Therapies (VIDEO)

Lab-on-a-Chip Simulates Heartbeat for Testing New Drug Therapies (VIDEO) | Shaping the Future of Medical Technology | Scoop.it

Researchers at the University of Michigan have developed a microfluidic chip that uses gravity and pressure differences to simulate a pulsating microenvironment within which tests can be performed.

Monika McDole-Russell's insight:

So glad to see that microfluidic chip technology (a type of technology that also includes organs-on-a-chip) continues to make steady progress in medtech.

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Artificial Vessels Designed to Degrade and Be Replaced by Natural Vasculature

Researchers at the Vienna University of Technology and Vienna Medical University in Austria have developed artificial blood vessels that are already proving themselves in animal models. Created out of thermoplastic polyurethane, the implants biodegrade into the body while being replaced by healthy endothelial cells. Importantly, this happens while the vessel is able to maintain its strength, slowly changing from an artificial implant into a real vessel made with the body’s endogenous cells.
Monika McDole-Russell's insight:

I'm familiar with the concept of bone and cartilage implants that act as scaffolds, then degrade and are replaced with their natural equivalent, but this is the first I've heard of vascular prostheses that can perform the same function. What a great concept!

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