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Rescooped by António Soares Gomes from Preventive Medicine
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Caution to pregnant women on red meat diabetes link

Caution to pregnant women on red meat diabetes link | Scientific Information & News | Scoop.it
“ (Medical Xpress)—Pregnant women and women planning to become pregnant can make use of the summer holiday season to adjust their diets and reduce the risk of gestational diabetes, according to researchers at the University of Adelaide's Robinson...”
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Rescooped by António Soares Gomes from Stem cell news
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Mechanism that Prevents Stem Cell Aging

Mechanism that Prevents Stem Cell Aging | Scientific Information & News | Scoop.it
“ A research group at the University of Valencia, Spain, led by Isabel Fariñas Gómez, at the Molecular Neurobiology Unit, has discovered a mechanism that maintains stem cell populations in the brain ...”
Via Ajan Reginald
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Rescooped by António Soares Gomes from Cancer Care and Treatment
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Nausea And Vomiting

Nausea And Vomiting | Scientific Information & News | Scoop.it
“ Side effects of chemotherapy are the most dreaded of all times. Fortunately, there are different ways to prevent, treat and manage the side effects today, and cancer specialists take special care t...”
Via Pratima Patil
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Rescooped by António Soares Gomes from Prostate Cancer Research Digest
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Boston Research Institutes, Hospitals Launch Clinical Genomics Center

Boston Research Institutes, Hospitals Launch Clinical Genomics Center | Scientific Information & News | Scoop.it
"A quartet of Boston-area research centers including Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston Children's Hospital, and the Broad Institute have teamed to create a new clinical cancer genomics center that will be headquartered at Dana-Farber. Dana-Farber said today that the new Joint Center for Cancer Precision Medicine will harness a wide range of scientific resources and clinical capabilities from the partners to treat cancer patients and feed treatment data into research programs. The multiple capabilities these partners will share and use in the new center include DNA sequencing and other tumor molecular profiling tools, pathology, radiology, surgery, computational interpretation, and tumor modeling systems, they said."
Via Cancer Commons
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Rescooped by António Soares Gomes from TAL effector science
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Conditional targeted genome editing using somatically expressed TALENs in C. elegans - Nature Biotech.

Conditional targeted genome editing using somatically expressed TALENs in C. elegans - Nature Biotech. | Scientific Information & News | Scoop.it
(via T. Lahaye, thx) Cheng et al, 2013 We have developed a method for the generation of conditional knockouts in Caenorhabditis elegans by expressing transcription activator–like effector nucleases (TALENs) in somatic cells. Using germline transformation with plasmids encoding TALENs under the control of an inducible or tissue-specific promoter, we observed effective gene modifications and resulting phenotypes in specific developmental stages and tissues. We further used this method to bypass the embryonic requirement of cor-1, which encodes the homolog of human severe combined immunodeficiency (SCID) protein coronin, and we determined its essential role in cell migration in larval Q-cell lineages. Our results show that TALENs expressed in the somatic cells of model organisms provide a versatile tool for functional genomics.
Via dromius
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Rescooped by António Soares Gomes from Breast Cancer News
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Researchers discover the genetic imprints and signatures left by DNA-damaging processes that lead to cancer

Researchers discover the genetic imprints and signatures left by DNA-damaging processes that lead to cancer | Scientific Information & News | Scoop.it
"Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide-range of cancers.Each mutational process leaves a particular pattern of mutations, an imprint or signature, in the genomes of cancers it has caused. By studying 7,042 genomes of people with the most common forms of cancer, the team uncovered more than 20 signatures of processes that mutate DNA. For many of the signatures, they also identified the underlying biological process responsible."
Via Susan Zager
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Rescooped by António Soares Gomes from TAL effector science
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Genome Engineering with TAL-Effector Nucleases and Alternative Modular Nuclease Technologies - Curr. Gene Therapy

Genome Engineering with TAL-Effector Nucleases and Alternative Modular Nuclease Technologies - Curr. Gene Therapy | Scientific Information & News | Scoop.it
(via T. Lahaye, thx) Over three years following the discovery of the TAL code, artificial TAL effector DNA binding domains have emerged as the premier platform for building site-specific DNA binding polypeptides for use in biological research. Here, we provide an overview of TAL effector and alternative modular DNA binding domain (mDBD) technologies, focusing on their use in established and emerging architectures for building site-specific endonucleases for genome engineering applications. We also discuss considerations for choosing TAL effector/mDBD or alternative nuclease technologies for genome engineering projects ranging from basic laboratory gene editing of cultured cell lines to therapeutics. Finally, we highlight how the rapid pace of development of mDBD-based, such as monomeric TALENs (I-TevI-TAL), and more recently RNA-guided nucleases (CRISPR-Cas9) has led to a transition in the field of genome engineering towards development of the next generation of technologies aimed at controlling events that occur after targeted DNA breaks are made.
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Rescooped by António Soares Gomes from Lung Cancer Research Digest
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Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma

Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma | Scientific Information & News | Scoop.it

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Rescooped by António Soares Gomes from Preventive Medicine
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Compound in grape seed extract 'kills prostate cancer cells'

Compound in grape seed extract 'kills prostate cancer cells' | Scientific Information & News | Scoop.it
“ A compound found in grape seed extract, called B2G2, can successfully kill human prostate cancer cells, according to a study from the University of Colorado Cancer Center.”
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Rescooped by António Soares Gomes from Psychology Matters
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New study turns autism research upside-down

New study turns autism research upside-down | Scientific Information & News | Scoop.it
The paper describes that it is now widely accepted that rather than a single entity, autism is multiple disorders. The variability in the nature and severity of behaviours is thought to exceed that of any other.
Via Stewart-Marshall
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Rescooped by António Soares Gomes from PARP Inhibitors Cancer Review
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Merck licenses PARPi from China

“ Merck Enters into Further Global Co-Development and Commercialization ...”
Via Krishan Maggon
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Rescooped by António Soares Gomes from TAL effector science
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Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions - Genetics

Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions - Genetics | Scientific Information & News | Scoop.it
(via T. Lahaye, thx) Lo et al, 2013 Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that induce random mutations at the break sites or precise homology-directed repair pathways that generate specific insertions or deletions guided by exogenously supplied DNA. Prior editing strategies using site-specific nucleases to modify the Caenorhabditis elegans genome achieved only the heritable disruption of endogenous loci through random mutagenesis by error-prone repair. Here we report highly effective strategies using TALE nucleases and RNA-guided CRISPR/Cas9 nucleases to induce error-prone repair and homology-directed repair to create heritable, precise insertion, deletion, or substitution of specific DNA sequences at targeted endogenous loci. Our robust strategies are effective across nematode species diverged by 300 million years, including necromenic nematodes (Pristionchus pacificus), male/female species (Caenorhabditis species 9), and hermaphroditic species (C. elegans). Thus, genome-editing tools now exist to transform nonmodel nematode species into genetically tractable model organisms. We demonstrate the utility of our broadly applicable genome-editing strategies by creating reagents generally useful to the nematode community and reagents specifically designed to explore the mechanism and evolution of X chromosome dosage compensation. By developing an efficient pipeline involving germline injection of nuclease mRNAs and single-stranded DNA templates, we engineered precise, heritable nucleotide changes both close to and far from DSBs to gain or lose genetic function, to tag proteins made from endogenous genes, and to excise entire loci through targeted FLP-FRT recombination.
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Rescooped by António Soares Gomes from TAL effector science
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Efficient TALEN Construction for Bombyx mori Gene Targeting - PLOS One

Efficient TALEN Construction for Bombyx mori Gene Targeting - PLOS One | Scientific Information & News | Scoop.it
(via T. Lahaye, thx) Takasu et al, 2013 We showed earlier that ZFNs and TALENs are able to induce NHEJ mutations in the B. mori genome. In order to optimize our mutagenesis protocol, we modified one of the reported truncated TALEN scaffolds and optimized it for use in the B. mori embryo. We also established a novel B. mori somatic cell assay suitable for the preselection of highly efficient TALENs directly in the B. mori model system. We compared the efficiency of several TALEN pairs based on three different frameworks using the BmBLOS2 gene. The new active TALENs show one order of magnitude higher efficiency than those we used previously. We confirmed the utility of our improved protocol by mutagenesis of the autosomal gene, red egg (Bm-re) and showed that it allows obtaining homozygous mutants in G1. Our procedure minimizes the chance of failure in B. mori gene targeting experiments.
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Rescooped by António Soares Gomes from #Communication
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Single-cell RNA sequencing yields genetic makeup of human and mouse embryos in unprecedented detail

Single-cell RNA sequencing yields genetic makeup of human and mouse embryos in unprecedented detail | Scientific Information & News | Scoop.it
“ UCLA scientists, in collaboration with teams in China, have used the powerful technology of single-cell RNA sequencing to track the genetic development of a”
Via Prof. Hankell
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Rescooped by António Soares Gomes from Science News
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Fighting evolution with evolution – using viruses to target drug-resistant bacteria | Not Exactly Rocket Science | Discover Magazine

Fighting evolution with evolution – using viruses to target drug-resistant bacteria | Not Exactly Rocket Science | Discover Magazine | Scientific Information & News | Scoop.it
Bacteria | We are losing the war against infectious bacteria. They are becoming increasingly resistant to our antibiotics, and we have few new drugs in the pipeline.
Via Sakis Koukouvis
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Scooped by António Soares Gomes
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Isn't he special! - Gene Expression | DiscoverMagazine.com

Isn't he special! - Gene Expression | DiscoverMagazine.com | Scientific Information & News | Scoop.it
“Credit: Marrabbio2There's a nice letter in Nature right now with an understated title, Mating advantage for rare males in wild guppy populations. But if yo (A fundamental question at the heart of evolutionary biology: Why does diversity persist?”
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