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Hepatitis C Research and News: Hep C anti-virals not as effective as trials suggest

Hepatitis C Research and News: Hep C anti-virals not as effective as trials suggest | Science -Facts and Fiction | Scoop.it

Doctors cannot assume results from clinical trials are transferable to their clinical practice, conclude the authors of a study showing hepatatis C treatments in some patients are less effective than suggested by trial data.

The retrospective study compared the results of pegylated interferon and ribavirin therapy in pharmaceutical trials to those of over 400 patients treated in a tertiary hospital and found that though results for patients with genotypes 1 and 2 infections were comparable, the results for genotype 3 patients were “inferior” in a clinical setting.

Of the 187 genotype 3 patients included in the hospital cohort 72% achieve a sustained virological response (SVR) compared to 76-84% in pharmaceutical trials, the researchers reported in Internal Medicine Journal.

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Scripps Finds Antibody that Could Prevent Hep C | Hepatitis Central News, Updates and Commentary

Using an approach called exhaustive panning, Scripps researchers have advanced the search for a Hepatitis C vaccine by identifying the antibody AR4A.

Promising Vaccine Targets On Hepatitis C Virus

ScienceDaily (Apr. 3, 2012) -- A team led by scientists at The Scripps Research Institute has found antibodies that can prevent infection from widely differing strains of hepatitis C virus (HCV) in cell culture and animal models.

HCV's very high rate of mutation normally helps it to evade its host's immune system. The newly discovered antibodies, however, attach to sites on the viral envelope that seldom mutate. One of the new antibodies, AR4A, shows broader HCV neutralizing activity than any previously reported anti-HCV antibody.

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Conserve Coastal Forests of Tanzania to Prevent Species Extinction - ForceChange

Conserve Coastal Forests of Tanzania to Prevent Species Extinction - ForceChange | Science -Facts and Fiction | Scoop.it
The coastal forests of Tanzania are disappearing. These forests are home to an astonishing array of endemic plant and animal species. Urge the government of Tanzania to protect coastal forests to prevent extinction of plant and animal species.
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Enzyme in saliva helps regulate blood glucose

Enzyme in saliva helps regulate blood glucose | Science -Facts and Fiction | Scoop.it
Scientists from the Monell Center report that blood glucose levels following starch ingestion are influenced by genetically-determined differences in salivary amylase, an enzyme that breaks down dietary starches.
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Neuroskeptic: The Age of ADHD

Neuroskeptic: The Age of ADHD | Science -Facts and Fiction | Scoop.it

Diagnosed rates of ADHD in American children have skyrocketed in the past 20 years, and use of medication such as Ritalin and Adderall has increased by an even greater amount.

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Basel Institute of Commons and Economics -

Basel Institute of Commons and Economics - | Science -Facts and Fiction | Scoop.it

Is Social Capital still a grassroot issue for eggheads and intellectuals? We want to share our new results in defining and measuring Social Capital with you. One application of our innovative research is the impact on sovereign debt: download this press release and the background paper.

But what is Social Capital? Social capital is what people provide to others without expecting anything in return. Everyday kindness, volunteering, advice and practical help, gifts offered to neighbours and friends, civic engagement, in short: active involvement in a community.

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Von der Vergangenheit bis in die Zukunft: Neue Klimasimulationen für Wissenschaft und Gesellschaft — DKRZ

Von der Vergangenheit bis in die Zukunft: Neue Klimasimulationen für Wissenschaft und Gesellschaft — DKRZ | Science -Facts and Fiction | Scoop.it
Wissenschaftler des Max-Planck-Instituts für Meteorologie (MPI-M) und des Deutschen Klimarechenzentrums (DKRZ) haben mit dem neuen Klimamodell des MPI-M neue Klimasimulationen durchgeführt.
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What have we got in common with a Gorilla? - Wellcome Trust Sanger Institute

What have we got in common with a Gorilla? - Wellcome Trust Sanger Institute | Science -Facts and Fiction | Scoop.it

What have we got in common with a Gorilla?
An insight into human evolution from the gorilla genome sequence
Researchers announce today that they have completed the genome sequence for the gorilla - the last genus of the living great apes to have its genome decoded. While confirming that our closest relative is the chimpanzee, the team show that much of the human genome more closely resembles the gorilla than it does the chimpanzee genome.

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Nature News Special : Alan Turing at 100

Nature News Special : Alan Turing at 100 | Science -Facts and Fiction | Scoop.it

Alan Turing, born a century ago this year, is best known for his wartime code-breaking and for inventing the 'Turing machine' – the concept at the heart of every computer today. But his legacy extends much further: he founded the field of artificial intelligence, proposed a theory of biological pattern formation and speculated about the limits of computation in physics. In this collection of features and opinion pieces, Nature celebrates the mind that, in a handful of papers over a tragically short lifetime, shaped many of the hottest fields in science today.

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Iconic marine mammals are 'swimming in sick seas' of terrestrial pathogens

Iconic marine mammals are 'swimming in sick seas' of terrestrial pathogens | Science -Facts and Fiction | Scoop.it
Parasites and pathogens infecting humans, pets and farm animals are increasingly being detected in marine mammals such as sea otters, porpoises, harbor seals and killer whales along the Pacific coast of the US and Canada, and better surveillance is...
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PLoS ONE: Discordance between Liver Biopsy and FibroScan® in Assessing Liver Fibrosis in Chronic Hepatitis B: Risk Factors and Influence of Necroinflammation

PLoS ONE: Discordance between Liver Biopsy and FibroScan® in Assessing Liver Fibrosis in Chronic Hepatitis B: Risk Factors and Influence of Necroinflammation | Science -Facts and Fiction | Scoop.it
PLoS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Russians revive Ice Age flower from frozen burrow

Russians revive Ice Age flower from frozen burrow | Science -Facts and Fiction | Scoop.it
It was an Ice Age squirrel's treasure chamber, a burrow containing fruit and seeds that had been stuck in the Siberian permafrost for over 30,000 years.
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Abbott Hepatitis C Combo Impressive in Small Study

Abbott Hepatitis C Combo Impressive in Small Study | Science -Facts and Fiction | Scoop.it
A combination of oral hepatitis C drugs being developed by Abbott Laboratories realized cure rates exceeding 90 percent in treatment-na ve patients, ...
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Insight into how pharma manipulates research evidence: a case study

Insight into how pharma manipulates research evidence: a case study | Science -Facts and Fiction | Scoop.it
TRANSPARENCY AND MEDICINE – A series examining issues from ethics to the evidence in evidence-based medicine, the influence of medical journals to the role of Big Pharma in our present and future health…...
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Looking Back on the Limits of Growth

Looking Back on the Limits of Growth | Science -Facts and Fiction | Scoop.it
Forty years after the release of the groundbreaking study, were the concerns about overpopulation and the environment correct?
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Quand la mer monte…

Quand la mer monte… | Science -Facts and Fiction | Scoop.it

Surging Seas: A Project of Climate Central

Map pages show threats from sea level rise and storm surge to all 3000+ coastal towns, cities, counties and states in the Lower 48.


Via Karen Bastien, malik berkati
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Overview of Theoretical and Experimental Progress in Low Energy Nuclear Reactions (LENR) (22 March 2012)

Overview of Theoretical and Experimental Progress in Low Energy Nuclear Reactions (LENR) (22 March 2012) | Science -Facts and Fiction | Scoop.it
An overview will be given on the main progress made –since March 1989- through experimental/theoretical studies on thermal/nuclear anomalies observed in forced interactions of Hydrogen isotopes (H, D), in non-equilibrium conditions, with pure or...
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Hepatitis C Phase 3 Trials Underway for TMC435 | Hepatitis Central News, Updates and Commentary

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Timothy Mousseau | Papers - Academia.edu

Timothy Mousseau | Papers - Academia.edu | Science -Facts and Fiction | Scoop.it
Timothy Mousseau's Papers: Abundance of birds in Fukushima as judged from Chernobyl, Senescent sperm performance in old male birds, Møller, A. P., A. Bonisoli-Alquati, G. Rudolfsen, and T.A. Mousseau.
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Polyculture versus Monoculture: Which is Better?

Polyculture versus Monoculture: Which is Better? | Science -Facts and Fiction | Scoop.it
Find out why having organic farms that practice polyculture is better than monoculture agricultural practices.
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The School of Life : Charles Fernyhough Asks Does Neuroscience Change The Way We Understand Ourselves?

The School of Life : Charles Fernyhough Asks Does Neuroscience Change The Way We Understand Ourselves? | Science -Facts and Fiction | Scoop.it
Brain science is everywhere. The ‘neuro-’ prefix has been used to jazz up approaches to self-help, ethics, aesthetics, marketing, economics, even parenting.
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ScienceGuide - No barriers for science, please

ScienceGuide - No barriers for science, please | Science -Facts and Fiction | Scoop.it

“We are now publishing 73% of our journals open access, while five years ago it was zero. It has increased dramatically. Ten of these are fully open access already.” Jason Wilde, commercial director of the Nature Publishing Group discusses hot issues like open access, research fraud and the global R&D-revolution.
"NPG itself has different models in which we publish the relevant academic content," Wilde explains the role the academic publisher has given itself in the discussion around open access. While some journals, like PLoS ONE and its SURF Research Day keynote speaker Cameron Neylon, are propagating full open access, NPG believes in a more subtle approach, a more 'hybrid model' with a variety of different ways of publishing.

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Hepatitis C Relapse Leads to Gilead Woes | Hepatitis Central News, Updates and Commentary

Because three quarters of Hepatitis C patients relapsed after stopping Gilead's GS-7977, the company's financial profile suffered.

Gilead Drops After Patients Relapse on Hepatitis C Drug

 

Gilead press release http://www.gilead.com/pr_1662331

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