The East Indian Sandalwood tree, Santalum album L. yields one of the costliest heartwood and precious essential oil. Unsurprisingly, this endangered forest species is victimized due to unmet global demands, poaching, over harvesting, and an epidemic mycoplasmal spike disease. The in vitro micropropagation endeavors have resulted in defined in vitro stages such as somatic embryos that are amenable to mass production in bioreactors. We report on somatic embryo production in a 10 L air-lift type bioreactor, and compared the growth and biochemical parameters with that of a 2 L air-lift type bioreactor. For the 10 L bioreactor with the biomass (475.7±18 g FW, P <0.01), concomitantly santalols (5.2±0.15 mg L−1; P <0.05), phenolics (31±1.6 mg L−1), and arabinogalactan proteins (AGPs) (39±3.1 mg L−1; P <0.05) are produced in 28 d. In addition, we identified and quantified several santalols and phenolics by means of HPTLC and RP-HPLC analyses, respectively. Results indicate that 10 L capacity air-lift bioreactors are capable of supporting somatic embryo cultures, while the extra cellular medium provides opportunities for production of raw industrial materials such as santalols, phenolics, and AGPs. This will prove useful for further optimization and scale-up studies of plant-produced metabolites.