Salus (Health)
Follow
Find
83 views | +0 today
Rescooped by Pasquale Valente from The future of medicine and health
onto Salus (Health)
Scoop.it!

Revealed: Scientists ‘edit’ DNA to correct adult genes and cure diseases

Revealed: Scientists ‘edit’ DNA to correct adult genes and cure diseases | Salus (Health) | Scoop.it
A genetic disease has been cured in living, adult animals for the first time using a revolutionary genome-editing technique that can make the smallest changes to the vast database of the DNA molecule with pinpoint accuracy.

Via Wildcat2030
more...
No comment yet.
Salus (Health)
P4 (predictive, preventive, personalized, partecipatory) medicine
Your new post is loading...
Your new post is loading...
Scooped by Pasquale Valente
Scoop.it!

Salus

Salus | Salus (Health) | Scoop.it
Salus, by pasquale valente: P4 (predictive, preventive, personalized, partecipatory) medicine
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

WHO/Europe | Country profiles on noncommunicable diseases published

WHO/Europe | Country profiles on noncommunicable diseases published | Salus (Health) | Scoop.it
WHO has published profiles on noncommunicable diseases (NCDs) for all Member States, including the 53 countries in the WHO European Region. Where data are available, the profiles estimate for each country the current burden of and recent trends in NCD mortality, the prevalence of selected major risk factors and the national health system’s capacity to respond. They update the profiles produced in 2011.
more...
No comment yet.
Rescooped by Pasquale Valente from The future of medicine and health
Scoop.it!

Skin layer grown from human stem cells could replace animals in drug and cosmetics testing | KurzweilAI

Skin layer grown from human stem cells could replace animals in drug and cosmetics testing | KurzweilAI | Salus (Health) | Scoop.it

An international team led by King’s College London and the San Francisco Veteran Affairs Medical Center (SFVAMC) has developed the first lab-grown epidermis (the outermost skin layer) with a functional permeability barrier akin to real skin.

The new epidermis, grown from human pluripotent stem cells, offers a cost-effective alternative lab model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.

The epidermis, the outermost layer of human skin, forms a protective interface between the body and its external environment, preventing water from escaping and microbes and toxins from entering.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing or produce an in vitro (lab) model for large-scale drug screening. That’s because the number of cells that can be grown from a single skin biopsy sample has been limited.

The new study, published in the journal Stem Cell Reports (open access), describes the use of human induced pluripotent stem cells (iPSC) (stem cells that can develop into different types of body cells) to produce an unlimited supply of pure keratinocytes (the predominant cell type in the outermost layer of skin). These new keratinocytes closely match keratinocytes generated from other stem-cell types: human embryonic stem cells (hESC) and primary keratinocytes from skin biopsies.


Via Wildcat2030
more...
No comment yet.
Rescooped by Pasquale Valente from The future of medicine and health
Scoop.it!

Revealed: Scientists ‘edit’ DNA to correct adult genes and cure diseases

Revealed: Scientists ‘edit’ DNA to correct adult genes and cure diseases | Salus (Health) | Scoop.it
A genetic disease has been cured in living, adult animals for the first time using a revolutionary genome-editing technique that can make the smallest changes to the vast database of the DNA molecule with pinpoint accuracy.

Via Wildcat2030
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Coxsackievirus B4 can infect human pancreas ductal cells and persist... [Cell Mol Life Sci. 2013] - PubMed - NCBI

Abstract

The role of enteroviruses, especially Coxsackievirus B (CVB), in type 1 diabetes is suspected, but the mechanisms of the virus-induced or aggravated pathogenesis of the disease are unknown. The hypothesis of an enterovirus-induced disturbance of pancreatic β-cells regeneration has been investigated in the human system. The infection of human pancreas ductal cells and pancreatic duct cell line, PANC-1, with CVB4E2 has been studied. Primary ductal cells and PANC-1 cells were infectable with CVB4E2 and a RT-PCR assay without extraction displayed that a larger proportion of cells harbored viral RNA than predicted by the detection of the viral capsid protein VP1 by indirect immunofluorescence. The detection of intracellular positive- and negative-strands of enterovirus genomes in cellular extracts by RT-PCR and the presence of infectious particles in supernatant fluids during the 37 weeks of monitoring demonstrated that CVB4E2 could persist in the pancreatic duct cell line. A persistent infection of these cells resulted in an impaired expression of Pdx1, a transcription factor required for the formation of endocrine pancreas, and a disturbed formation of islet-like cell aggregates of which the viability was decreased. These data support the hypothesis of an impact of enteroviruses onto pancreatic ductal cells which are involved in the renewal of pancreatic β-cells.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Vibration may help heal chronic wounds

Vibration may help heal chronic wounds | Salus (Health) | Scoop.it
Wounds may heal more quickly if exposed to low-intensity vibration, report researchers. The finding, in mice, may hold promise for the 18 million Americans who have type 2 diabetes, and especially the quarter of them who will eventually suffer from foot ulcers. Their wounds tend to heal slowly and can become chronic or worsen rapidly.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Evaluating Online Sources of Health Information - National Cancer Institute

Evaluating Online Sources of Health Information - National Cancer Institute | Salus (Health) | Scoop.it
Information to help people evaluate the source and credibility of health information that they find online.
more...
No comment yet.
Rescooped by Pasquale Valente from immunology
Scoop.it!

Taking immune cells for a test drive | Broad Institute of MIT and Harvard

Taking immune cells for a test drive | Broad Institute of MIT and Harvard | Salus (Health) | Scoop.it

Via Krishan Maggon , Gilbert Faure au nom de l'ASSIM
Pasquale Valente's insight:

 121 genetic variants linked to the induction of immune gene expression.

more...
Gilbert Faure au nom de l'ASSIM's curator insight, April 2, 12:38 AM

This work is the first installment from the ImmVar group, explained Christophe Benoist. This analysis was coordinated with parallel studies within the ImmVar project on regulatory genetics in resting blood cells, and in activated T lymphocytes, such that the innate and adaptive arms of the immune system are represented. “It’s been a fun program for all the collaborators,” said Benoist, Broad associate member, professor at HMS, and leader of the ImmVar consortium. “The team has done a fantastic job in putting together this beautiful paper, but stay tuned for other important stories to come.”

Scooped by Pasquale Valente
Scoop.it!

First comprehensive atlas of human gene activity released | KurzweilAI

First comprehensive atlas of human gene activity released | KurzweilAI | Salus (Health) | Scoop.it
Samples profiled in FANTOM5 (credit: Alistair R. R. Forrest et al./Nature) A large international consortium of researchers has produced the first
more...
No comment yet.
Rescooped by Pasquale Valente from healthcare technology
Scoop.it!

Constructing a large network of multiple infections to determine how multiple parasites interact within humans

Constructing a large network of multiple infections to determine how multiple parasites interact within humans | Salus (Health) | Scoop.it

Imagine going to the doctor with an infection and being sent home with a course of drugs. Unknown to your doctor you actually have two infections. If you take the drugs will the other infection go away by itself? What if you take the drugs and the other infection gets worse? This quandary faces those treating patients with multiple infections.

 

A new study led by former University of Sheffield PhD student Dr Emily Griffiths, in collaboration with the universities of Edinburgh, Liverpool and Zürich, has taken a novel approach to understanding this problem, shedding light on how multiple parasites interact within humans.

 

The study compiled a list of many of the parasites that infect humans, another list of the parts of the body consumed by each parasite, and also information about how the immune system responds to each parasite. This information was used to construct a large network of multiple infections in humans - a bit like a food web of infections inside the human body.

 

Building this network revealed some previously unknown patterns, something that could pave the way for new treatment strategies which help tackle multiple infections. For example, groups of parasites often share similar parts of their host, and these groups are prime candidates for coordinated treatment.

 

Dr Griffiths, who carried out the research during her PhD in the Department of Animal and Plant Sciences at the University of Sheffield, said: "After studying the fascinating range of hundreds of different infections that can occur in the same person at the same time, we've shown that we could better treat patients if we know what parasites are eating inside our bodies.

 

"Our web has revealed the ways hundreds of parasites could live together, which means that we can develop new coordinated treatments that help fight more than one infection.

 

 more at http://www.medicalnewstoday.com/releases/273905.php ;


Via nrip
more...
Beverly Morgan's curator insight, March 18, 6:41 AM

More than one infection in your body can be the reason your not getting any relief from your meds....more research to come but this is a great start on how diagnosing the multiple infections can help identify coordinated treatments! 

Rescooped by Pasquale Valente from Longevity science
Scoop.it!

ATHENA "desktop human" for drug and toxic agent screening gets a liver

ATHENA "desktop human" for drug and toxic agent screening gets a liver | Salus (Health) | Scoop.it

A five-year, US$19 million multi-institutional effort is working on developing a "desktop human" that could reduce the need for animal testing in the development of new drugs. The "homo minitus" is a drug and toxicity analysis system that would comprise four human organ constructs interconnected to mimic the response of human organs. The project has now reported success in the development of its first organ construct, a human liver construct that responds to exposure to a toxic chemical much like a real liver.

 

 


Via Ray and Terry's
Pasquale Valente's insight:

the ultimate goal of the project is to, "build a lung that breathes, a heart that pumps, a liver that metabolizes and a kidney that excretes."

more...
No comment yet.
Rescooped by Pasquale Valente from Innovation in healthcare, medicine and life sciences
Scoop.it!

Perform blood tests with your smartphone screen (Wired UK)

Perform blood tests with your smartphone screen (Wired UK) | Salus (Health) | Scoop.it

A diagnostic tool that uses a smartphone screen to perform blood tests has been developed by a microengineering laboratory at the Swiss Federal Institute of Technology (EPFL)


Via ehealthgr
more...
ehealthgr's curator insight, March 26, 3:12 AM
Check the company's website: http://qloudlab.com/
Scooped by Pasquale Valente
Scoop.it!

'Biological pacemaker' tested in lab

'Biological pacemaker' tested in lab | Salus (Health) | Scoop.it
Grow-your-own pacemakers are a step closer to reality, after pioneering experiments in pigs.
more...
No comment yet.
Rescooped by Pasquale Valente from The future of medicine and health
Scoop.it!

Young mice blood may hold key to age-related diseases in humans - video

New studies suggest blood from young mice has rejuvenating effects on older mice, and may lead to new therapeutic approaches to age-related diseases in humans

Via Wildcat2030
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

A Continuous Semantic Space Describes the Representation of Thousands of Object and Action Categories across the Human Brain

A Continuous Semantic Space Describes the Representation of Thousands of Object and Action Categories across the Human Brain | Salus (Health) | Scoop.it

Humans can see and name thousands of distinct object and action categories, so it is unlikely that each category is represented in a distinct brain area. A more efficient scheme would be to represent categories as locations in a continuous semantic space mapped smoothly across the cortical surface. To search for such a space, we used fMRI to measure human brain activity evoked by natural movies. We then used voxelwise models to examine the cortical representation of 1,705 object and action categories. The first few dimensions of the underlying semantic space were recovered from the fit models by principal components analysis. Projection of the recovered semantic space onto cortical flat maps shows that semantic selectivity is organized into smooth gradients that cover much of visual and nonvisual cortex. Furthermore, both the recovered semantic space and the cortical organization of the space are shared across different individuals.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Research sheds new light on impact of diabetes on the brain

Research sheds new light on impact of diabetes on the brain | Salus (Health) | Scoop.it
Researchers from the University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust have discovered diabetic nerve damage causes more harm in the brain than previously thought, shedding new light on the disease.
more...
No comment yet.
Rescooped by Pasquale Valente from Cancer - Advances, Knowledge, Integrative & Holistic Treatments
Scoop.it!

Simple Blood Test for Solid Cancer May be Effective

Simple Blood Test for Solid Cancer May be Effective | Salus (Health) | Scoop.it
A US team has developed an ultra-sensitive way of detecting tumor DNA in the bloodstream, bringing closer the prospect of a simple general blood test for diverse solid cancers.

Via Graham Player Ph.D.
more...
Graham Player Ph.D.'s curator insight, April 8, 6:19 AM

Researchers from Stanford University School of Medicine have devised an ultra-sensitive method for finding DNA from cancer tumors in the bloodstream. The new method identified around half of patients with stage 1 lung cancer and all patients with stage 2 or higher disease.

Cancer cells divide and die, even without treatment. When a cancer cell dies, the DNA in its nucleus escapes into the bloodstream. This is present in small concentrations - something like 1 in 1,000 or 10,000 bits of DNA in the blood can be from a dead cancer cell in a person with cancer.

So a test that can quickly and non-invasively monitor the tiny concentrations of cancer cell DNA would be really useful to clinicians who need to estimate the size of the tumor, how it changes over time, and monitor a patient's response to treatment.



The team found a way to do this by boosting existing methods for extracting, processing and analyzing the DNA. They called their approach CAPP-Seq (which is short for Cancer Personalized Profiling by deep Sequencing).

The researchers say CAPP-Seq may also have potential as a prognostic tool. When they tested one patient thought to have been successfully treated for lung cancer, they found low levels of circulating tumor DNA. The cancer came back in that patient, and they died

Rescooped by Pasquale Valente from Health & Life Extension
Scoop.it!

Top 10 Israeli Advances In Autism

Top 10 Israeli Advances In Autism | Salus (Health) | Scoop.it
From research to social and educational programs, Israel excels in the struggle to understand autism and help families deal with this developmental disorder.
Via Tonya Scholz
more...
No comment yet.
Rescooped by Pasquale Valente from The future of medicine and health
Scoop.it!

World's first computational psychiatry centre opens in London

World's first computational psychiatry centre opens in London | Salus (Health) | Scoop.it
Centre will use latest technology to gain insights into human cognition and learn how it becomes disrupted in disorders

-

The worlds' first computational psychiatry centre has opened in London with a mission to shine a new light on human cognition and understand how it becomes disrupted in disorders such as depression and dementia.

Backed by a five-year €5m (£4.1m) investment from the Max Planck Society and UCL, the centre, which is named after its funders and will be based in London and Berlin, will use powerful modern technology in an effort to create more detailed models than ever before of how the human brain works.

Professor Ray Dolan, academic co-leader of the centre, said: "The brain is at some level an information processing machine and we have to understand what it's doing and how that information processor is working. We are trying to understand normal cognition with respect to the type of processes that go awry in psychiatric disorders and in ageing, we then intend to apply these models to understand ageing, depression or any other psychiatric disorders where we think the models may be appropriate. "


Via Wildcat2030
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Monkeys that cut calories live longer

Monkeys that cut calories live longer | Salus (Health) | Scoop.it
Long-running study reopens debate on benefits of reduced-intake diets.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Effect of ginger root on cyclooxygenase-1 ... [Eur J Cancer Prev. 2013] - PubMed - NCBI

Effect of ginger root on cyclooxygenase-1 ... [Eur J Cancer Prev. 2013] - PubMed - NCBI | Salus (Health) | Scoop.it

Elevated tissue levels of prostaglandin E2, produced by cyclooxygenase (COX), are an early event in colorectal cancer (CRC). Data suggest the efficacy of nonsteroidal anti-inflammatory drugs, such as cancer preventives, in the inhibition of COX activity; however, side effects of nonsteroidal anti-inflammatory pose unacceptable limitations. Ginger has been reported to have anti-inflammatory activities with significant CRC preventive potential. We investigated whether consumption of 2.0 g ginger daily regulated the level of two key enzymes that control prostaglandin E2 production, COX-1 and NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Thirty participants at normal and 20 participants at increased risk for CRC were randomized and given 2.0 g/day ginger or placebo for 28 days. Flexible sigmoidoscopy was used to obtain colon biopsies at baseline and the end of the study. Tissue levels of COX-1 and 15-PGDH were assessed using western blotting

Pasquale Valente's insight:

"After ginger consumption, participants at increased risk for CRC had a significantly reduced colonic COX-1 protein level (23.8±41%) compared with the placebo group (18.9±52%; P=0.03)"

more...
No comment yet.
Rescooped by Pasquale Valente from Longevity science
Scoop.it!

MIT’s fast synthesis system could boost peptide-drug development | KurzweilAI

MIT’s fast synthesis system could boost peptide-drug development | KurzweilAI | Salus (Health) | Scoop.it

Small protein fragments, also called peptides, are promising as drugs because they can be designed for very specific functions inside living cells, but manufacturing the peptides takes several weeks, making it difficult to obtain large quantities, and to rapidly test their effectiveness.

 

A team of MIT chemists and chemical engineers has designed a way to manufacture peptides in mere hours. The new system, described in a recent issue of the journal ChemBioChem, could have a major impact on peptide drug development, says Bradley Pentelute, an assistant professor of chemistry and leader of the research team.

 

 


Via Ray and Terry's
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Hepatoprotective effect of silymarin

Hepatoprotective effect of silymarin | Salus (Health) | Scoop.it

The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such asSilybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.

more...
No comment yet.
Rescooped by Pasquale Valente from Websalute, e-santé, e-health, #hcsmeuit
Scoop.it!

Tackling Cancer Through Big Data and the Cloud | Linux.com

Tackling Cancer Through Big Data and the Cloud | Linux.com | Salus (Health) | Scoop.it

Researchers at the National Cancer Institutes are building an open source public cloud to broaden access to cancer genomics data.


Via Giovanna Marsico
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Visualizing Health - YouTube

When it comes to our bodies, data abounds. Unfortunately, the availability of data and the ability to use it to make effective decisions are not the same thi...
more...
No comment yet.