Salus (Health)
Follow
Find tag "personalized"
182 views | +0 today
Salus (Health)
P4 (predictive, preventive, personalized, partecipatory) medicine
Your new post is loading...
Your new post is loading...
Scooped by Pasquale Valente
Scoop.it!

Getting close and personal

Getting close and personal | Salus (Health) | Scoop.it
“THERE is no treatment.” This is the conclusion of an Egyptian papyrus, written around 3000BC, that is the oldest known description of the scourge that is now...
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. [Clin Pharmacol Ther. 2013] - PubMed - NCBI

Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. [Clin Pharmacol Ther. 2013] - PubMed - NCBI | Salus (Health) | Scoop.it

Abstract

The progressive elucidation of the molecular pathogenesis of cancer has fueled the rational development of targeted drugs for patient populations stratified by genetic characteristics. Here we discuss general challenges relating to molecular diagnostics and describe predictive biomarkers forpersonalized cancer medicine. We also highlight resistance mechanisms for epidermal growth factor receptor (EGFR) kinase inhibitors in lung cancer. We envisage a future requiring the use of longitudinal genome sequencing and other omics technologies alongside combinatorial treatment to overcome cellular and molecular heterogeneity and prevent resistance caused by clonal evolution.

Pasquale Valente's insight:

"The solution to the inevitable challenge of polygenic cancer drug resistance is to identify not only all exploitable molecular abnormalities but also the full range of resistance mechanisms and there after to employ precision combinatorial targeted therapy matched specifically to the fully defined tumor profile"

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Personalized Medicine: The Future is Now | FDA Voice

Personalized Medicine: The Future is Now | FDA Voice | Salus (Health) | Scoop.it
"We now know that patients with similar symptoms may have different diseases with different causes. Individual patients who may appear to have the same disease may respond differently (or not at all) to treatments of that disease.FDA has been playing a critical role in the growth of this new era for a number of years."
Pasquale Valente's insight:
- See more at: http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/PersonalizedMedicine/UCM372421.pdf
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Personalized Medicine and Health Economics: Is Small the New Big? A White Paper

Personalized Medicine and Health Economics: Is Small the New Big? A White Paper | Salus (Health) | Scoop.it

This White Paper is based on an International Workshop (Personalized Medicine: The future is already here but are we ready for it?”) that was held at the Dead Sea in Israel on 5–6 September 2012.

Pasquale Valente's insight:

Raju Kucherlapati  “Implementation of personalized medicine is going to result in better outcomes for patients, and I truly believe there is going to be reduced cost. It’s happening today, it’s not some time in the future. This is going to be the normal practice as we move forward.”

more...
No comment yet.