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Salus (Health)
P4 (predictive, preventive, personalized, partecipatory) medicine
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Simple blood test can detect lung cancer with high sensitivity and specificity -- LONDON, MILAN, and SAN DIEGO, Jan. 13, 2014 /PRNewswire/ --

Simple blood test can detect lung cancer with high sensitivity and specificity -- LONDON, MILAN, and SAN DIEGO, Jan. 13, 2014 /PRNewswire/ -- | Salus (Health) | Scoop.it
LONDON, MILAN, and SAN DIEGO, Jan. 13, 2014 /PRNewswire/ -- Simple blood test can detect lung cancer with high sensitivity and specificity - results from large clinical validation study published in the Journal of Clinical Oncology.
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Test For Cancer In A Drop Of Blood

Test For Cancer In A Drop Of Blood | Salus (Health) | Scoop.it
Chinese scientists have tested a new cancer biomarker detection kit in clinical trials, showing that it can be used to diagnose lung cancer.
Pasquale Valente's insight:

"The kit requires only a drop of blood (approximately 10 microliters) to measure Hsp90 alpha protein levels for disease monitoring and therapeutic evaluation."

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Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. [Clin Pharmacol Ther. 2013] - PubMed - NCBI

Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. [Clin Pharmacol Ther. 2013] - PubMed - NCBI | Salus (Health) | Scoop.it

Abstract

The progressive elucidation of the molecular pathogenesis of cancer has fueled the rational development of targeted drugs for patient populations stratified by genetic characteristics. Here we discuss general challenges relating to molecular diagnostics and describe predictive biomarkers forpersonalized cancer medicine. We also highlight resistance mechanisms for epidermal growth factor receptor (EGFR) kinase inhibitors in lung cancer. We envisage a future requiring the use of longitudinal genome sequencing and other omics technologies alongside combinatorial treatment to overcome cellular and molecular heterogeneity and prevent resistance caused by clonal evolution.

Pasquale Valente's insight:

"The solution to the inevitable challenge of polygenic cancer drug resistance is to identify not only all exploitable molecular abnormalities but also the full range of resistance mechanisms and there after to employ precision combinatorial targeted therapy matched specifically to the fully defined tumor profile"

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Test could help prevent unnecessary breast cancer treatment, say scientists

Test could help prevent unnecessary breast cancer treatment, say scientists | Salus (Health) | Scoop.it
Women with early stages of breast cancer may no longer face treatment without knowing whether it will become life-threatening
Pasquale Valente's insight:

Professor Clare Isacke, from the Institute of Cancer Research, London, said the research was "potentially very important" because it was one of few papers that deal with early stage lesions and showed that "this integrin [alpha v beta 6] is a biomarker [biological marker] of those DCIS cases that are going to do worse".

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