Lymph nodes, to be worthy of note, as one of the peripheral lymphoid organs of the immune system, are garrisons of B, T, and other immune cells but provide “home” for metastatic cancer cells. However, it is still a pending ...
It seems that nearly every day, scientists connect another medical condition to atypical gut bacteria populations. Researchers have claimed that gut bacteria play a role not just in digestive health but even in basic brain function and mental health. Certain bacteria are so clearly good for us that several companies are looking to market pills filled not with chemical drugs, but with bacteria. A few pharmaceutical startups have already begun testing bacterial medicines in hopes of finding the right strain or stains of bacteria to cure widespread and still mysterious illnesses.
A nanoparticle delivery system exploits biochemical and cellular pathways in tumor cells to deliver two different drugs to different locations in the cell. ...
Treating tumors is combining two or more drugs, which has the effect of decreasing toxicity and increasing the synergistic effects between the drugs. However, the efficacy of this kind of cocktail treatment suffers when the drugs require access to different parts of the cell, a bit like fighting a battle by depositing all your archers on the same spot as your infantrymen.
By making use of nanoparticle-based carriers, researchers at North Carolina State University are able to transport multiple drugs into cancerous cells optimally and precisely...
We find that: a) The energy absorbed by living matter during exposure to environmentally accounted EMFs is normally well below the thermal level. b) All existing methods for SARestimation, especially those based upon tissue conductivity and internal electric field, have serious deficiencies. c) The only method to estimate SAR without large error is by measuring temperature increases within biological tissue, which normally are negligible for environmental EMF intensities, and thus cannot be measured.
Pasquale Valente's insight:
"SAR actually refers to thermal effects, while the vast majority of the recorded biological effects from man-made non-ionizing environmental radiation are non-thermal. "
Systematic monitoring of interactions between resident and recruited cells should provide key information not only about early events in loss of immune surveillance, but it would help making informed decisions for balancing the inherent tumoricidal (Yin) and tumorigenic (Yang) properties of immune system and effective preventive and therapeutic approaches and accurate risk assessment toward improvement of public health.
Finger pricks and careful eating are an important part of the daily routine for most people with diabetes. While automated glucose meters are a growing option, they can still create discomfort and other inconveniences.
Google wants to go in a totally different direction with a project announced today:smart contact lenses that can detect glucose levels via the wearer’s tears and alert them when levels dip or rise.
This isn’t the first smart contact lens, and several options already exist for people interested in monitoring glaucoma. But Babak Parviz, who also leads the Google Glass team, is a smart contact pioneer and Google which is a secretive division of Google dedicated to difficult, future-looking projects, has a reputation for ably pursuing projects like this.
The lens works via a small wireless chip and glucose sensor embedded between two pieces of soft material. The current prototype puts out a reading once a second. Google is also interested in integrating an LED light, which could light up to alert the wearer of dangerous glucose levels.
The lab is now looking for parters to help bring the lens to market. It would also like to develop an app that would help wearers read and manage the data the lens takes in.
The lens could help people with diabetes monitor their daily health and recognize dangerous situations.
LONDON, MILAN, and SAN DIEGO, Jan. 13, 2014 /PRNewswire/ -- Simple blood test can detect lung cancer with high sensitivity and specificity - results from large clinical validation study published in the Journal of Clinical Oncology.
Background Recently, individualized or personalized medicine (PM) has become a buzz word in the academic as well as public debate surrounding health care. However, PM lacks a clear definition and is open to interpretation. This conceptual vagueness complicates public discourse on chances, risks and limits of PM. Furthermore, stakeholders might use it to further their respective interests and preferences. For these reasons it is important to have a shared understanding of PM. In this paper, we present a sufficiently precise as well as adequate definition of PM with the potential of wide acceptance.
Methods For this purpose, in a first step a systematic literature review was conducted to understand how PM is actually used in scientific practice. PubMed was searched using the keywords “individualized medicine”, “individualised medicine”, “personalized medicine” and “personalised medicine” connected by the Boolean operator OR. A data extraction tabloid was developed putting forward a means/ends-division. Full-texts of articles containing the search terms in title or abstract were screened for definitions. Definitions were extracted; according to the means/ends distinction their elements were assigned to the corresponding category. To reduce complexity of the resulting list, summary categories were developed inductively from the data using thematic analysis. In a second step, six well-known criteria for adequate definitions were applied to these categories to derive a so-called precising definition.
Results We identified 2457 articles containing the terms PM in title or abstract. Of those 683 contained a definition of PM and were thus included in our review. 1459 ends and 1025 means were found in the definitions. From these we derived the precising definition: PM seeks to improve stratification and timing of health care by utilizing biological information and biomarkers on the level of molecular disease pathways, genetics, proteomics as well as metabolomics.
Conclusions Our definition includes the aspects that are specific for developments labeled as PM while, on the other hand, recognizing the limits of these developments. Furthermore, it is supported by the quantitative analysis of PM definitions in the literature, which suggests that it it is widely acceptable and thus has the potential to avoid the above mentioned issues.
The hardening of the arteries, also called atherosclerosis, that can lead to heart attack or stroke. has also been linked to autoimmune disorders. It has not been clear why these diseases are related, but a study published January 9th by Cell Press in the journal Immunity reveals that a molecule that causes atherosclerosis also activates white blood cells called T cells, causing clinical symptoms of autoimmune disease to worsen in mice. The findings shed light on the tight link between autoimmunity and atherosclerosis, opening new avenues for the treatment of autoimmune disorders.
"The lesson from this study is that immune diseases are not always a matter of immune system alone," says senior study author Yeonseok Chung of the University of Texas Health Science Center at Houston. "With our findings, we have just started to understand how factors in the circulatory system impact the immune system."
In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer.