Mice with immune cells unable to use vitamin D developed atherosclerosis and insulin resistance, precursors of heart disease and type 2 diabetes. The mechanisms uncovered may lead to novel therapies. The findings also suggest that vitamin D might help prevent the complications of diabetes and inflammation.
Cinco estudiantes de la Brigham Young University han desarrollado una de las sillas de ruedas eléctricas más pequeñas y baratas del mercado. Su proyecto se originó al tratar de ayudar a una familia cuyos hijos pequeños sufren una atrofia muscular espinal. Los pequeños hermanos, de 20 meses y 3 años, usaban sillas de ruedas convencionales que hacían que se cansaran fácilmente.
Hace unos meses presentamos en el blog el proyecto VISC+, un ambicioso proyecto del Departament de Salut de la Generalitat de Catalunya dirigido a permitir el uso de datos asistenciales para proyectos de investigación, estudios epidemiológicos y estrategias de mejora de la calidad. Pero el proyecto nació con mucho rechazo a su alrededor
The latest exoskeleton technology doesn't need an outside power source to boost your strength. It harnesses the power of your own muscles to put a spring in your step instead. And soon baby boomers could be using it to keep hiking and jogging just a few years longer.
The new devices, described Wednesday in Nature, are still just in the prototype phase. But the researchers who created the inexpensive, easy-to-wear exoskeletons believe they could be ubiquitous in another decade. They're quite unlike the hulking, "Iron Man"-like suits that others have created to help people walk more easily. These little braces don't require any outside power, and they make walking 7 percent more efficient with nothing but a well-placed spring system. They can't support someone who can't stand on her own like a bulkier, motor-aided suit might. But for people who can walk but have difficulty doing so, the boot-like new apparatus could help create a more balanced, comfortable gait.
Just under 10 percent less energy per step doesn't sound like much -- it's the equivalent of removing a 10-pound backpack. According to study co-author Gregory Sawicki, a biomedical engineer and locomotion physiologist in the joint NC State/University of North Carolina-Chapel Hill Department of Biomedical Engineering, people using the braces don't really notice the difference -- until it's gone.
Scientists are using previously top-secret technology to zoom through the human body down to the level of a single cell. Scientists are also using cutting-edge microtome and MRI technology to examine how movement and weight bearing affects the movement of molecules within joints, exploring the relationship between blood, bone, lymphatics and muscle.
UNSW biomedical engineer Melissa Knothe Tate is using previously top-secret semiconductor technology to zoom through organs of the human body, down to the level of a single cell.
A world-first UNSW collaboration that uses previously top-secret technology to zoom through the human body down to the level of a single cell could be a game-changer for medicine, an international research conference in the United States has been told.
The imaging technology, developed by high-tech German optical and industrial measurement manufacturer Zeiss, was originally developed to scan silicon wafers for defects.
UNSW Professor Melissa Knothe Tate, the Paul Trainor Chair of Biomedical Engineering, is leading the project, which is using semiconductor technology to explore osteoporosis and osteoarthritis.
Using Google algorithms, Professor Knothe Tate -- an engineer and expert in cell biology and regenerative medicine -- is able to zoom in and out from the scale of the whole joint down to the cellular level "just as you would with Google Maps," reducing to "a matter of weeks analyses that once took 25 years to complete."
Her team is also using cutting-edge microtome and MRI technology to examine how movement and weight bearing affects the movement of molecules within joints, exploring the relationship between blood, bone, lymphatics and muscle. "For the first time we have the ability to go from the whole body down to how the cells are getting their nutrition and how this is all connected," said Professor Knothe Tate. "This could open the door to as yet unknown new therapies and preventions."
Professor Knothe Tate is the first to use the system in humans. She has forged a pioneering partnership with the US-based Cleveland Clinic, Brown and Stanford Universities, as well as Zeiss and Google to help crunch terabytes of data gathered from human hip studies. Similar research is underway at Harvard University and Heidelberg in Germany to map neural pathways and connections in the brains of mice.
Universidad Central de Venezuela primera Universidad Pública y Autónoma del país, dedicada a la Docencia, Investigación y Extensión, ubicada en la Ciudad Universitaria de Caracas, proyectada arquitectónicamente por el maestro Carlos Raúl Villanueva, decretada en el año 2000 como Patrimonio Cultural de la Humanidad
Mariano Fernandez S.'s insight:
12 de abril Día del Tecnólogo Cardiopulmonar
Una carrera de compromiso con el paciente y de apoyo en la actualización del médico venezolano
A pesar de la ingente cantidad de datos que proveen los registros electrónicos de pacientes, los sistemas ERP y otros sistemas TIC sanitarios, nuestro conocimiento sobre los pacientes es aún pequeño. Esta brecha entre información y conocimiento marca una gran diferencia en términos de efectividad terapéutica y de costes.
De este modo ha surgido como complemento (que no alternativa) a los sistemas electrónicos de salud el concepto de inteligencia de paciente.
Jonathan Leviss of AMC Health, which recently announced a major partnership with Qualcomm Life, sees a bright future for vital sign monitors in the home -- but not one old-fashioned symbol of the practicing physician
Distasteful as it sounds, the transplantation of fecal matter is more successful for treating Clostridium difficile infections than previously thought. The research, published in the open access journal Microbiome, reveals that healthy changes to a patient's microbiome are sustained for up to 21 weeks after transplant, and has implications for the regulation of the treatment.
Clostridium difficile infections are a growing problem, leading to recurrent cases of diarrhea and severe abdominal pain, with thousands of fatalities worldwide every year. The infection is thought to work by overrunning the intestinal microbiome - the ecosystem of microorganisms that maintain a healthy intestine.
Fecal microbiota transplantation was developed as a method of treating C. difficile infection, and is particularly successful in patients who suffer repeat infections. Fecal matter is collected from a donor, purified, mixed with a saline solution and placed in a patient, usually by colonoscopy.
Previous research has shown that the fecal microbiota of patients resembles that of the donor, but not much is known about the short and long term stability of fecal microbiota transplanted into recipients.
In this research, Michael Sadowsky and colleagues at the University of Minnesota collected fecal samples from four patients before and after their fecal transplants. Three patients received freshly prepared microbiota from fecal matter and one patient received fecal microbiota that had previously been frozen. All received fecal microbiota from the same pre-qualified donor.
The team compared the pre- and post-transplant fecal microbial communities from the four patients, as well as from 10 additional patients with recurring C. difficile infections, to the sequences of normal subjects described in the Human Microbiome Project. In addition, they looked at the changes in fecal bacterial composition in recipients over time, and compared this to the changes observed within samples from the donor.
Surprisingly, after transplantation, patient samples appeared to sustain changes in their microbiome for up to 21 weeks and remained within the spectrum of fecal microbiota characterized as healthy.
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