De cara a la próxima Copa del Mundo en Brasil, la Organización Panamericana de la Salud (OPS) llama a protegerse contra la importación de la poliomielitis, el sarampión y otras enfermedades prevenibles por vacunación. Acceda a toda la información sobre esta iniciativa.
Facebook has bought Moves, an app that keeps track of your daily exercise and fitness routine as well as the places you visit.
The news was revealed in a blog posted Thursday by ProtoGeo Oy, the company behind Moves. No details about the deal were revealed, simply that Facebook has acquired both the company and the app.
Available for iOS and Android users, Moves is a free app that can automatically track your walks, jogs, bike rides, and other forms of fitness. It can also keep track of the places you visit with a map that shows you where you've been and how you got there.
An app that tracks your daily activities can raise privacy concerns, especially with Facebook the new owner. The company has had its share of privacy complaints in the past. But Facebook has already tried to address such concerns.
El espiral del ascenso del dengue parece no detenerse este año. Hasta principios del mes de abril se registraron 19.133 casos en el país, tal como reseñó el Boletín Epidemiológico del Ministerio de la Salud de la semana 14, que comprende del 30 de (...)
Plan Nacional sobre Drogas: Es la aplicación gratuita para dispositivos móviles (teléfonos inteligentes y tabletas) del Plan Nacional Sobre Drogas de España. Esta herramienta es de información y concienciación dirigida principalmente a la población en general que quiera conocer de manera rigurosa los riesgos de las drogas y otras adicciones sin sustancias.
A rare occurrence in the earliest days of a pregnancy produces an unusual and mystifying outcome: Identical twin fetuses are conceived of the same meeting of egg and sperm. And despite their shared DNA, one of the twins has Down syndrome (the most common genetic cause of intellectual impairment), but the other does not.
But these aborted identical twins -- one with an extra copy of chromosome 21 and the other without -- offered scientists a remarkable opportunity: given the twin fetuses' otherwise exact DNA match, how would this one difference translate across the genome?
That natural experiment allowed a group of geneticists from Switzerland, Spain, the Netherlands and France to distill some fundamental insights into how chromosomes -- and the genetic blueprints they contain -- dictate the behavior of cells across the body. They found that when gene expression is altered by, say, an added chromosome, it is altered in consistent patterns in every chromosome, not just the one with the irregularity.
A few things follow from that: First, it lends credence to scientists' long-running suspicion that chromosomes -- between 50 and 100 base pairs of DNA -- may be organized along functional lines, such that certain stretches of a chromosome may hold the genetic blueprint for proteins that work together in some predictable way. If they are organized functionally, they're not random. And if they're not random, they can (someday) be understood.
Trisomy 21 is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in trisomy 21, and to eliminate the noise of genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for trisomy 21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either upregulated or downregulated. These gene expression dysregulation domains (GEDDs) can be defined by the expression level of their gene content, and are well conserved in induced pluripotent stem cells derived from the twins’ fibroblasts. Comparison of the transcriptome of the Ts65Dn mouse model of Down’s syndrome and normal littermate mouse fibroblasts also showed GEDDs along the mouse chromosomes that were syntenic in human. The GEDDs correlate with the lamina-associated (LADs) and replication domains of mammalian cells. The overall position of LADs was not altered in trisomic cells; however, the H3K4me3 profile of the trisomic fibroblasts was modified and accurately followed the GEDD pattern. These results indicate that the nuclear compartments of trisomic cells undergo modifications of the chromatin environment influencing the overall transcriptome, and that GEDDs may therefore contribute to some trisomy 21 phenotypes.
La velocidad de la caminata marcha preferida por la parca es de 0,82 m/seg (unos 3 km/h) bajo sus "condiciones de trabajo". Como ninguno de los hombres en el estudio con marchas superiores a 1,36 m/seg (unos 5 km/h) o más tuvo contacto con la muerte, esta pareciera ser la velocidad máxima de la parca.