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Whole brain cellular-level activity mapping in one second

Whole brain cellular-level activity mapping in one second | Salud Publica | Scoop.it

Neuroscientists at Howard Hughes Medical Institute have mapped the activity of nearly all the neurons in a vertebrate brain at cellular resolution, with signficant implications for neuroscience research and projects like the proposed Brain Activity Map (BAM).

 

Fast volumetric imaging of the larval zebrafish brain with light-sheet microscopy (credit: Misha B Ahrens, Philipp J Keller/Nature Methods)

The researchers used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain (which is composed of ~100,000 neurons) of a fish larva at 0.8 Hz (an image every 1.3 seconds), with single-cell resolution.

 

This represents the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior, as Nature Methodsmethagora blog noted.

The authors saw correlated activity patterns at the cellular level that spanned large areas of the brain — pointing to the existence of broadly distributed functional circuits.

 

The next steps will be to determine the causal role that these circuits play in behavior — something that will require improvements in the methods for 3D optogenetics, the blog said. Obtaining the detailed anatomical map of these circuits will also be key to understand the brain’s organization at its deepest level.


Via Dr. Stefan Gruenwald
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Que hay en salud? Tendencias y nuevas formas de lograr mejoras sanitarias en las comunidades
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La Salud 2.0 y la atención de la salud en la era digital | Fernández Silano | Revista Médica de Risaralda

La Salud 2.0 y la atención de la salud en la era digital | Fernández Silano | Revista Médica de Risaralda | Salud Publica | Scoop.it
La Salud 2.0 y la atención de la salud en la era digital
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Technology takes on breast cancer - Newsroom - ANU

Technology takes on breast cancer - Newsroom - ANU | Salud Publica | Scoop.it
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2014 GLOBAL HOMICID BOOK / Estudio Mundial de Homicidios #epidemiologia #pdf

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Green Paper on mobile health ("mHealth")

The objective of this Green Paper, announced in the eHealth Action Plan 2012-2020, is to launch a broad stakeholder consultation on existing barriers and issues related to mHealth deployment and help
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Recursos para que los jóvenes aprendan a comer saludablemente

Recursos para que los jóvenes aprendan a comer saludablemente | Salud Publica | Scoop.it
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The Public Health Crisis Hiding in Our Food

The Public Health Crisis Hiding in Our Food | Salud Publica | Scoop.it
A new British study shows many lives can be saved by cutting salt.
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Conoce la app que da a conocer los riesgos de las drogas

Conoce la app que da a conocer los riesgos de las drogas | Salud Publica | Scoop.it
Plan Nacional sobre Drogas: Es la aplicación gratuita para dispositivos móviles (teléfonos inteligentes y tabletas) del Plan Nacional Sobre Drogas de España. Esta herramienta es de información y concienciación dirigida principalmente a la población en general que quiera conocer de manera rigurosa los riesgos de las drogas y otras adicciones sin sustancias.

Via Ramon Aragon
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Identical twins, one with Down syndrome the other one without: a genetic mystery

Identical twins, one with Down syndrome the other one without: a genetic mystery | Salud Publica | Scoop.it
A rare occurrence in the earliest days of a pregnancy produces an unusual and mystifying outcome: Identical twin fetuses are conceived of the same meeting of egg and sperm. And despite their shared DNA, one of the twins has Down syndrome (the most common genetic cause of intellectual impairment), but the other does not.


But these aborted identical twins -- one with an extra copy of chromosome 21 and the other without -- offered scientists a remarkable opportunity: given the twin fetuses' otherwise exact DNA match, how would this one difference translate across the genome?


That natural experiment allowed a group of geneticists from Switzerland, Spain, the Netherlands and France to distill some fundamental insights into how chromosomes -- and the genetic blueprints they contain -- dictate the behavior of cells across the body. They found that when gene expression is altered by, say, an added chromosome, it is altered in consistent patterns in every chromosome, not just the one with the irregularity.


A few things follow from that: First, it lends credence to scientists' long-running suspicion that chromosomes -- between 50 and 100 base pairs of DNA -- may be organized along functional lines, such that certain stretches of a chromosome may hold the genetic blueprint for proteins that work together in some predictable way. If they are organized functionally, they're not random. And if they're not random, they can (someday) be understood.


Trisomy 21 is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in trisomy 21, and to eliminate the noise of genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for trisomy 21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either upregulated or downregulated. These gene expression dysregulation domains (GEDDs) can be defined by the expression level of their gene content, and are well conserved in induced pluripotent stem cells derived from the twins’ fibroblasts. Comparison of the transcriptome of the Ts65Dn mouse model of Down’s syndrome and normal littermate mouse fibroblasts also showed GEDDs along the mouse chromosomes that were syntenic in human. The GEDDs correlate with the lamina-associated (LADs) and replication domains of mammalian cells. The overall position of LADs was not altered in trisomic cells; however, the H3K4me3 profile of the trisomic fibroblasts was modified and accurately followed the GEDD pattern. These results indicate that the nuclear compartments of trisomic cells undergo modifications of the chromatin environment influencing the overall transcriptome, and that GEDDs may therefore contribute to some trisomy 21 phenotypes.


Via Dr. Stefan Gruenwald
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Why Most Published Research Findings Are False

Why Most Published Research Findings Are False | Salud Publica | Scoop.it
PLOS Medicine is an open-access, peer-reviewed medical journal that publishes outstanding human studies that substantially enhance the understanding of human health and disease.
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La importancia de la alfabetización en salud | Imma Grau

La importancia de la alfabetización en salud | Imma Grau | Salud Publica | Scoop.it
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Mobile Applications for Diabetics: A Systematic Review and Expert-Based Usability Evaluation Considering the Special Requirements of Diabetes Patients Age 50 Years or Older

Mobile Applications for Diabetics: A Systematic Review and Expert-Based Usability Evaluation Considering the Special Requirements of Diabetes Patients Age 50 Years or Older
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Can an Internet-Based Health Risk Assessment Highlight Problems of Heart Disease Risk Factor Awareness? A Cross-Sectional Analysis

Can an Internet-Based Health Risk Assessment Highlight Problems of Heart Disease Risk Factor Awareness? A Cross-Sectional Analysis
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¿A qué velocidad camina la Muerte? | medicinapreventiva.info

¿A qué velocidad camina la Muerte? | medicinapreventiva.info | Salud Publica | Scoop.it
La velocidad de la caminata marcha preferida por la parca es de 0,82 m/seg (unos 3 km/h) bajo sus "condiciones de trabajo". Como ninguno de los hombres en el estudio con marchas superiores a 1,36 m/seg (unos 5 km/h) o más tuvo contacto con la muerte, esta pareciera ser la velocidad máxima de la parca.
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Un estudiante desarrolla una app para ayudar en la prevención del cáncer de mama

Un estudiante desarrolla una app para ayudar en la prevención del cáncer de mama | Salud Publica | Scoop.it

anjay Sreekumar es un estudiante de la Escuela de Ingeniería de la Universidad Nacional de Australia que ha desarrollado una App para smartphones con la colaboración de la Organización contra el Cáncer Young Adults Program que permite a las mujeres reconocer irregularidades a través de mediciones mensuales, conocer si deben asistir a exámenes médicos y así porvenir el cáncer de mama.

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Some 437,000 people murdered worldwide in 2012, according to new UNODC study

United Nations Office on Drugs and Crime Web Site
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Semana de Vacunación de las Américas: tu mejor jugada

Semana de Vacunación de las Américas: tu mejor jugada | Salud Publica | Scoop.it
De cara a la próxima Copa del Mundo en Brasil, la Organización Panamericana de la Salud (OPS) llama a protegerse contra la importación de la poliomielitis, el sarampión y otras enfermedades prevenibles por vacunación. Acceda a toda la información sobre esta iniciativa.
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Facebook acquires health and fitness tracking app Moves

Facebook acquires health and fitness tracking app Moves | Salud Publica | Scoop.it

Facebook has bought Moves, an app that keeps track of your daily exercise and fitness routine as well as the places you visit.

The news was revealed in a blog posted Thursday by ProtoGeo Oy, the company behind Moves. No details about the deal were revealed, simply that Facebook has acquired both the company and the app.

Available for iOS and Android users, Moves is a free app that can automatically track your walks, jogs, bike rides, and other forms of fitness. It can also keep track of the places you visit with a map that shows you where you've been and how you got there.

An app that tracks your daily activities can raise privacy concerns, especially with Facebook the new owner. The company has had its share of privacy complaints in the past. But Facebook has already tried to address such concerns.


Via Alex Butler
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El dengue registra 19.133 casos (Abril/2014)

El dengue registra 19.133 casos (Abril/2014) | Salud Publica | Scoop.it
El espiral del ascenso del dengue parece no detenerse este año. Hasta principios del mes de abril se registraron 19.133 casos en el país, tal como reseñó el Boletín Epidemiológico del Ministerio de la Salud de la semana 14, que comprende del 30 de (...)
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ágora MÉDICA: FORMÁNDOSE CON TWITTER

ágora MÉDICA: FORMÁNDOSE CON TWITTER | Salud Publica | Scoop.it
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Pharma Market - Innovación - Las búsquedas en Google relacionadas con la salud son más frecuentes a principios de semana

Pharma Market - Innovación - Las búsquedas en Google relacionadas con la salud son más frecuentes a principios de semana | Salud Publica | Scoop.it
Ingeniería · Consultorías.
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How video surveillance could improve hygiene - Futurity

How video surveillance could improve hygiene - Futurity | Salud Publica | Scoop.it
A new study finds that video surveillance can provide insights into hand-washing behavior among children in the developing world.
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Presentación del libro de Alfabetización en Salud: de la información a la acción ..:: Salupedia ::.. Tu Enciclopedia de la Salud

Presentación del libro de Alfabetización en Salud: de la información a la acción ..:: Salupedia ::.. Tu Enciclopedia de la Salud | Salud Publica | Scoop.it
Presentación del libro de Alfabetización en Salud: de la información a la acción
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La e-Salud es un gran apoyo para niños con autismo

La e-Salud es un gran apoyo para niños con autismo | Salud Publica | Scoop.it
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Would You Tell Everyone This? Facebook Conversations as Health Promotion Interventions

Would You Tell Everyone This? Facebook Conversations as Health Promotion Interventions
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The Use of Social Networking Sites for Public Health Practice and Research: A Systematic Review

The Use of Social Networking Sites for Public Health Practice and Research: A Systematic Review
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Científico que investigó sobre las células STAP pide que se retire el artículo

Científico que investigó sobre las células STAP pide que se retire el artículo | Salud Publica | Scoop.it
"Presento mis sinceras disculpas por los problemas causados", declaró en una rueda de prensa Yoshiki Sasai, un importante científico japonés en el sector de la investigación celular
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