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Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity | Salt and Sugar | Scoop.it
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Scientists can’t agree whether salt is killing us. Here’s why.

Scientists can’t agree whether salt is killing us. Here’s why. | Salt and Sugar | Scoop.it
Researchers pull back the curtain on why this debate has been so polarizing.
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Pappa2 is linked to salt-sensitive hypertension in Dahl S rats

Pappa2 is linked to salt-sensitive hypertension in Dahl S rats
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A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension | Salt and Sugar | Scoop.it
Author Summary The focus of blood pressure (BP) GWAS has been the identification of common DNA sequence variants associated with the phenotype; this approach provides only one dimension of molecular information about BP. While it is a critical dimension, analyzing DNA variation alone is not sufficient for achieving an understanding of the multidimensional complexity of BP physiology. The top loci identified by GWAS explain only about 1 percent of inter-individual BP variability. In this study
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Low Sodium Intake — Cardiovascular Health Benefit or Risk? — NEJM

Low Sodium Intake — Cardiovascular Health Benefit or Risk? — NEJM | Salt and Sugar | Scoop.it
Editorial from The New England Journal of Medicine — Low Sodium Intake — Cardiovascular Health Benefit or Risk?
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Evolution of salinity tolerance from transcriptome to physiological system - Scott - 2013 - Molecular Ecology - Wiley Online Library

Evolution of salinity tolerance from transcriptome to physiological system - Scott - 2013 - Molecular Ecology - Wiley Online Library | Salt and Sugar | Scoop.it
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Particle swarm optimization algorithm for analyzing SNP–SNP interaction of renin-angiotensin system genes against hypertension - Springer

Particle swarm optimization algorithm for analyzing SNP–SNP interaction of renin-angiotensin system genes against hypertension - Springer | Salt and Sugar | Scoop.it
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New Target Regions for Human Hypertension via Comparative Genomics

New Target Regions for Human Hypertension via Comparative Genomics | Salt and Sugar | Scoop.it
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
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GLOBAL ANALYSIS OF GENES INVOLVED IN FRESHWATER ADAPTATION IN THREESPINE STICKLEBACKS (GASTEROSTEUS ACULEATUS) - DeFaveri - 2011 - Evolution - Wiley Online Library

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Diet Strategies for Prevention of Hypertension in Japanese vs ...

Diet Strategies for Prevention of Hypertension in Japanese vs ... | Salt and Sugar | Scoop.it
OSAKA, Japan — A new review should serve as a reminder to physicians that lifestyle modifications are the cornerstone of hypertension prevention, but not all changes work for all populations.
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Local adaptation to salinity in the three-spined stickleback? - DeFaveri - 2013 - Journal of Evolutionary Biology

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Salt and blood pressure in children and adolescents

Journal of Human Hypertension is exclusively concerned with all clinical aspects of human hypertension. The journal publishes fully refereed original research papers from around the world.
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Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension

Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension | Salt and Sugar | Scoop.it
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Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure

Gene Silencing and Haploinsufficiency of  Csk  Increase Blood Pressure | Salt and Sugar | Scoop.it
Objective Recent genome-wide association studies have identified 33 human genetic loci that influence blood pressure. The 15q24 locus is one such locus that has been confirmed in Asians and Europeans. There are 21 genes in the locus within a 1-Mb boundary, but a functional link of these genes to blood pressure has not been reported. We aimed to identify a causative gene for blood pressure change in the 15q24 locus. Methods and Results CSK and ULK3 were selected as candidate genes based on eQTL analysis studies that showed the association between gene transcript levels and the lead SNP (rs1378942). Injection of siRNAs for mouse homologs Csk , Ulk3 , and Cyp1a2 (negative control) showed reduced target gene mRNA levels in vivo . However, Csk siRNA only increased blood pressure while Ulk3 and Cyp1a2 siRNA did not change it. Further, blood pressure in Csk +/- heterozygotes was higher than in wild-type, consistent with what we observed in Csk siRNA-injected mice. We confirmed that haploinsufficiency of Csk increased the active form of Src in Csk +/- mice aorta. We also showed that inhibition of Src by PP2, a Src inhibitor decreased high blood pressure in Csk +/- mice and the active Src in Csk +/- mice aorta and in Csk knock-down vascular smooth muscle cells, suggesting blood pressure regulation by Csk through Src. Conclusions Our study demonstrates that Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src, and these findings provide a novel therapeutic target for the treatment of hypertension.
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Hold the Salt: Vasopressor Role for BDNF

Hold the Salt: Vasopressor Role for BDNF | Salt and Sugar | Scoop.it
on of adaptive responses to environmental challenges (Mattson, 2015). Might there have been an ad
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BMC Genomics | Abstract | Discovery of osmotic sensitive transcription factors in fish intestine via a transcriptomic approach

Teleost intestine is crucial for seawater acclimation by sensing osmolality of imbibed seawater and regulating drinking and water/ion absorption. Regulatory genes for transforming intestinal function have not been identified. A transcriptomic approach was used to search for such genes in the intestine of euryhaline medaka.
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Relationship Between Nutrition and Blood Pressure: A Cross-Sectional Analysis from the NutriNet-Santé Study, a French Web-based Cohort Study

Relationship Between Nutrition and Blood Pressure: A Cross-Sectional Analysis from the NutriNet-Santé Study, a French Web-based Cohort Study | Salt and Sugar | Scoop.it
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http://time.com/3313332/salt-and-blood-pressure/

Salt Doesn’t Cause High Blood Pressure? Here’s What a New Study Says

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Association of Urinary Sodium and Potassium Excretion with Blood Pressure — NEJM

Association of Urinary Sodium and Potassium Excretion with Blood Pressure — NEJM | Salt and Sugar | Scoop.it
Original Article from The New England Journal of Medicine — Association of Urinary Sodium and Potassium Excretion with Blood Pressure
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Genome-Wide Association Studies Will Unlock the Genetic Basis of Hypertension

Genome-Wide Association Studies Will Unlock the Genetic Basis of Hypertension | Salt and Sugar | Scoop.it
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Genome sequence of hypertensive rat expected to uncover the genetic basis of hypertension in humans

Genome sequence of hypertensive rat expected to uncover the genetic basis of hypertension in humans | Salt and Sugar | Scoop.it
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
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Evolution of growth by genetic accommodation in Icelandic freshwater stickleback

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A gene with major phenotypic effects as a target for selection vs. homogenizing gene flow - Raeymaekers - 2013 - Molecular Ecology

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Salt and cardiovascular disease | BMJ

Footnotes ARTICLE Competing interest: None declared. Provenance and peer review: Commissioned; not externally peer reviewed.
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