Rheumatology-Rhumatologie
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Baicalin inhibits IL-17-mediated joint inflammation in murine adjuvant-induced arthritis. [Clin Dev Immunol. 2013] - PubMed - NCBI

Yang X, Yang J, Zou H.

Abstract

T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo. Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.


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chinese medicine active on Th17 cells?

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RHUMATOLOGIE - RHEUMATOLOGY

Obviously a topic of interest for so many people:

for the patient, it includes aching muscles, tendons and joints..

for MDs and researchers, it covers degenerative diseases as well as arthritis, often associated with various autoimmune diseases (see autoimmunity http://www.scoop.it/t/autoimmunity)

fortunately,

new diagnostic tools are available

and new biotherapies allowed to improve the prognosis and the quality of life of patients

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January 2016

still few viewers (#650) for this topic, but >1280 posts and 2000 views

much less than other immunology topics, but growing!

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Tackling Inflammation at its Genetic Roots: Applying Personalized Medicine to Autoimmunity and Cancer

Tackling Inflammation at its Genetic Roots: Applying Personalized Medicine to Autoimmunity and Cancer | Rheumatology-Rhumatologie | Scoop.it
While the term “personalized medicine” may evoke amusing images of a boutique-style doctor’s office, this particular approach to medicine could make an enormous impact on the lives of millions.
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Ageing and the pathogenesis of osteoarthritis : Nature Reviews Rheumatology : Nature Publishing Group

Ageing and the pathogenesis of osteoarthritis : Nature Reviews Rheumatology : Nature Publishing Group | Rheumatology-Rhumatologie | Scoop.it
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Krishan Maggon 's curator insight, May 19, 3:25 PM
NATURE REVIEWS RHEUMATOLOGY | REVIEW

Richard F. Loeser, John A. Collins & Brian O. Diekman

Nature Reviews Rheumatology (2016) doi:10.1038/nrrheum.2016.65 Published online 19 May 2016
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Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

Objectives
Immunity to citrullinated antigens is a hallmark of rheumatoid arthritis (RA). We set out to elucidate its biology by identifying and characterising citrullinated antigen-specific B cells in peripheral blood of patients with RA.
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Toll-like receptors and chronic inflammation in rheumatic diseases: new developments : Nature Reviews Rheumatology : Nature Publishing Group

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments : Nature Reviews Rheumatology : Nature Publishing Group | Rheumatology-Rhumatologie | Scoop.it
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Interleukin-6 in rheumatoid arthritis - from the laboratory to the bedside. - PubMed - NCBI

Interleukin-6 in rheumatoid arthritis - from the laboratory to the bedside. - PubMed - NCBI | Rheumatology-Rhumatologie | Scoop.it
Curr Pharm Des. 2015;21(17):2187-97. Research Support, Non-U.S. Gov't; Review
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Clinical and regulatory perspectives on biosimilar therapies and intended copies of biologics in rheumatology - Springer

Clinical and regulatory perspectives on biosimilar therapies and intended copies of biologics in rheumatology - Springer | Rheumatology-Rhumatologie | Scoop.it
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Avoiding Antimalarial Toxicity - Rosenbaum - Arthritis & Rheumatology - Wiley Online Library

Avoiding Antimalarial Toxicity - Rosenbaum - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Unexplained lower back pain? It could be ankylosing spondylitis

Unexplained lower back pain? It could be ankylosing spondylitis | Rheumatology-Rhumatologie | Scoop.it
Roughly a quarter of patients under 45 years suffering ongoing lower-back pain without an obvious other cause will have the disease ankylosing spondylitis.
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Immunoglobulin G4–Related Disease: Retrospective Analysis of 166 Patients - Sekiguchi - Arthritis & Rheumatology - Wiley Online Library

Immunoglobulin G4–Related Disease: Retrospective Analysis of 166 Patients - Sekiguchi - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
Objective: We aimed to investigate clinical and pathologic aspects of immunoglobulin (Ig) G4-related disease (IgG4-RD) in non-Asian populations.
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Family history of rheumatoid arthritis: an old concept with new developments : Nature Reviews Rheumatology : Nature Publishing Group

Family history of rheumatoid arthritis: an old concept with new developments : Nature Reviews Rheumatology : Nature Publishing Group | Rheumatology-Rhumatologie | Scoop.it
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Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis - Ridley - 2016 - Arthritis & Rheumatology - Wile...

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis - Ridley - 2016 - Arthritis & Rheumatology - Wile... | Rheumatology-Rhumatologie | Scoop.it
Objective
In the spondyloarthritides (SpA), increased numbers of CD4+ T cells express killer cell immunoglobulin-like receptor 3DL2 (KIR-3DL2).
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A Rheumatology State of Mind | RheumNow - Rheumatology News & Information

A Rheumatology State of Mind | RheumNow - Rheumatology News & Information | Rheumatology-Rhumatologie | Scoop.it
In 2012, a Medscape survey of US physicians revealed rheumatology as the most satisfying of medical specialties. This came as a surprise to many as rheumatologists see themselves as the Rodney Dangerfields of medical specialists.
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Novel Oral Therapies for Psoriasis and Psoriatic Arthritis

Abstract
Several classes of new oral therapy are in use or in development for the treatment of psoriasis.
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AbbVie's fight over Humira patents isn't over

AbbVie's fight over Humira patents isn't over | Rheumatology-Rhumatologie | Scoop.it
Visit Crain's Chicago Business for complete business news and analysis including healthcare, real estate, manufacturing, government, sports and more.
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Stem Cell Research & Therapy

Stem Cell Research & Therapy | Rheumatology-Rhumatologie | Scoop.it

Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies.

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IL-9 and Th9 cells in rheumatic diseases

IL-9 and Th9 cells in rheumatic diseases | Rheumatology-Rhumatologie | Scoop.it
IL-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private receptor IL-9R and the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit...
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Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis

Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis | Rheumatology-Rhumatologie | Scoop.it
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion.
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miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis - Sharma - 2016 - Medicinal Research Reviews - Wiley Online Library

miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis - Sharma - 2016 - Medicinal Research Reviews - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Articular cartilage: from formation to tissue engineering - Biomaterials Science (RSC Publishing)

Hyaline cartilage is the nonlinear, inhomogeneous, anisotropic, poro-viscoelastic connective tissue that serves as friction-reducing and load-bearing cushion in synovial joints and is vital for mammalian skeletal movements.
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Polyarthritis as a rare presentation of hydroxyapatite deposition disease - Aslam - Arthritis & Rheumatology - Wiley Online Library

Polyarthritis as a rare presentation of hydroxyapatite deposition disease - Aslam - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome - Nocturne - 2016 - Arthritis & Rheumatology - Wiley Online Library

Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome - Nocturne - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
Objective
To define parameters predictive of lymphoma development in patients with primary Sjögren's syndrome (SS).
Methods
A multicenter case–control survey was performed to identify predictors of lymphoma.
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Resolvin D1 ameliorates inflammatory arthritis in mouse model

Rheumatoid arthritis (RA) is a debilitating autoimmune disorder that is characterized by the accumulation of inflammatory cells within the fluid of the joints.
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Influenza and Pneumococcal Vaccination Uptake in Patients with Rheumatoid Arthritis Treated with Immunosuppressive Therapy in the UK: A Retrospective Cohort Study Using Data from the Clinical Pract...

Influenza and Pneumococcal Vaccination Uptake in Patients with Rheumatoid Arthritis Treated with Immunosuppressive Therapy in the UK: A Retrospective Cohort Study Using Data from the Clinical Pract... | Rheumatology-Rhumatologie | Scoop.it
Introduction Guidelines for the management of rheumatoid arthritis (RA) recommend using influenza and pneumococcal vaccinations to mitigate infection risk. The level of adherence to these guidelines is not well known in the UK.
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Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells: Immunity

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells: Immunity | Rheumatology-Rhumatologie | Scoop.it
Highlights •SFB enhance autoimmune arthritis, reflected by elevated auto-Ab, GC, and Tfh cell responses •SFB-driven differentiation and egress of PP Tfh cells to systemic sites cause disease •SFB induce PP Tfh cell differentiation by limiting the access of IL-2 to PP CD4+ T cells •DCs are required for SFB-mediated IL-2Rα suppression and Bcl-6 upregulation in PPs
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filamentous?
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