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Baicalin inhibits IL-17-mediated joint inflammation in murine adjuvant-induced arthritis. [Clin Dev Immunol. 2013] - PubMed - NCBI

Yang X, Yang J, Zou H.

Abstract

T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo. Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.


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chinese medicine active on Th17 cells?

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RHUMATOLOGIE - RHEUMATOLOGY

Obviously a topic of interest for so many people:

for the patient, it includes aching muscles, tendons and joints..

for MDs and researchers, it covers degenerative diseases as well as arthritis, often associated with various autoimmune diseases (see autoimmunity http://www.scoop.it/t/autoimmunity)

fortunately,

new diagnostic tools are available

and new biotherapies allowed to improve the prognosis and the quality of life of patients

Gilbert Faure au nom de l'ASSIM's insight:

January 2016

still few viewers (#650) for this topic, but >1280 posts and 2000 views

much less than other immunology topics, but growing!

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Rheumatoid arthritis, anti-tumour necrosis factor treatment, and risk of squamous cell and basal cell skin cancer: cohort study based on nationwide... - PubMed - NCBI

Rheumatoid arthritis, anti-tumour necrosis factor treatment, and risk of squamous cell and basal cell skin cancer: cohort study based on nationwide... - PubMed - NCBI | Rheumatology-Rhumatologie | Scoop.it

BMJ. 2016 Jan 28;352:i262. doi: 10.1136/bmj.i262.

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Frequency of axial spondyloarthritis diagnosis among patients seen by United States rheumatologists for evaluation of chronic back pain - Deodhar - Arthritis & Rheumatology - Wiley Online Library

Frequency of axial spondyloarthritis diagnosis among patients seen by United States rheumatologists for evaluation of chronic back pain - Deodhar - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective
To determine the proportion of patients with axial spondyloarthritis (axSpA) among those with chronic back pain and ≥1 of 3 SpA features in the United States (US).
Methods
The study was conducted at rheumatology practices...

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Spatial heterogeneity of systemic sclerosis in france: High prevalence in the northeastregion - Meyer - Arthritis & Rheumatology - Wiley Online Library

Spatial heterogeneity of systemic sclerosis in france: High prevalence in the northeastregion - Meyer - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective.To assess the prevalence of systemic sclerosis (SSc) in Eastern France and its spatial variation.
Methods.

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The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis - Khanna - 2016 - Arthritis & Rheumatology - Wiley Online...

The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis - Khanna - 2016 - Arthritis & Rheumatology - Wiley Online... | Rheumatology-Rhumatologie | Scoop.it

Objective
Early diffuse cutaneous systemic sclerosis (dcSSc) is characterized by rapid changes in the skin and internal organs.

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Characteristics and Survival of Anti–U1 RNP Antibody–Positive Patients With Connective Tissue Disease–Associated Pulmonary Arterial Hypertension - Sobanski - 2016 - Arthritis & Rheumatology - Wiley...

Characteristics and Survival of Anti–U1 RNP Antibody–Positive Patients With Connective Tissue Disease–Associated Pulmonary Arterial Hypertension - Sobanski - 2016 - Arthritis & Rheumatology - Wiley... | Rheumatology-Rhumatologie | Scoop.it

Objective
Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue diseases (CTDs).

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Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant–Induced Monoarthritis in Mice - Lopes - 2016 - Arthritis & Rheumatology - Wiley Online Library

Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant–Induced Monoarthritis in Mice - Lopes - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective
Activation of antiinflammatory cholinergic (vagal) pathways can reduce inflammation, and in vitro studies support a pivotal role of α7 nicotinic acetylcholine receptors (α7-nAChR), macrophages, and T cells in these events.

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The Elevated Secreted Immunoglobulin D Enhanced the Activation of Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis

The Elevated Secreted Immunoglobulin D Enhanced the Activation of Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis | Rheumatology-Rhumatologie | Scoop.it

Immunoglobulin D (IgD) is a surface immunoglobulin that is expressed as either membrane IgD (mIgD) or secreted IgD (sIgD). Researchers have shown that sIgD is often elevated in patients with autoimmune diseases.

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New BRAF (v raf murine sarcoma viral oncogene homologue B1) mutation in rheumatoid arthritis - Arnoux - Arthritis & Rheumatology - Wiley Online Library

New BRAF (v raf murine sarcoma viral oncogene homologue B1) mutation in rheumatoid arthritis - Arnoux - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective. Rheumatoid arthritis (RA) associated autoantibodies include antibodies directed at the kinase site of BRAF (v raf murine sarcoma viral oncogene homologue B1), a serine-threonine kinase involved in the mitogen-activated protein kinase...

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Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis: A Meta-Research Project

Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis:  A Meta-Research Project | Rheumatology-Rhumatologie | Scoop.it

Background Sponsors that seek to commercialize new drugs apply to the Food and Drug Administration (FDA) which independently analyzes the raw data and reports the results on its website.

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Arthritis Research & Therapy | Full text | Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity a...

The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB...

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Awards & Grants - Education and Training Awards - Rheumatology Research Foundation

Awards & Grants - Education and Training Awards - Rheumatology Research Foundation | Rheumatology-Rhumatologie | Scoop.it

Know a health pro looking to extend their #rheumedu? @RheumResearch offers grants for online courses up to $1500 https://t.co/eP02yVQimf

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Arthritis Research & Therapy | Full text | DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system

Synovial fibroblasts play a key role in joint destruction and regulation of the inflammatory infiltrate in established rheumatoid arthritis (RA). The mechanisms by which this occurs in the earliest stages of RA are largely unknown.

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Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response

Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response | Rheumatology-Rhumatologie | Scoop.it

Introduction In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission.

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Immunogenicity of biologic agents in rheumatoid arthritis patients: lessons for clinical practice

Immunogenicity of biologic agents in rheumatoid arthritis patients: lessons for clinical practice | Rheumatology-Rhumatologie | Scoop.it

Anti-drug antibodies (ADAbs) develop in up to a third of patients treated with biologic agents, with such immunogenicity being one of the main reasons for the loss of efficacy observed in an important proportion of patients treated with such agents.

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Rituximab done: what’s next in rheumatoid arthritis? A European observational longitudinal study assessing the effectiveness of biologics after rituximab treatment in rheumatoid arthritis

Objective. To compare the effectiveness of biologics after rituximab (RTX) treatment in RA.
Methods.

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Risk of End-stage Renal Disease in Patients with Lupus Nephritis, 1970 to 2015 A systematic review and Bayesian meta-analysis - Tektonidou - Arthritis & Rheumatology - Wiley Online Library

Risk of End-stage Renal Disease in Patients with Lupus Nephritis, 1970 to 2015 A systematic review and Bayesian meta-analysis - Tektonidou - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective. End-stage renal disease (ESRD) is a major consequence of lupus nephritis, but how this risk has changed over time is unknown.

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Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR-1+CD8+ T Cells - Rothe - 2016 - Arthritis & Rheumatology - Wiley Online Library

Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR-1+CD8+ T Cells - Rothe - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective
Leukocyte immunoglobulin-like receptor 1 (LIR-1) is up-regulated by cytomegalovirus (CMV), which in turn, has been associated with premature aging and more severe joint disease in patients with rheumatoid arthritis (RA).

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Breg Cells Are Numerically Decreased and Functionally Impaired in Patients With Systemic Sclerosis - Mavropoulos - 2016 - Arthritis & Rheumatology - Wiley Online Library

Breg Cells Are Numerically Decreased and Functionally Impaired in Patients With Systemic Sclerosis - Mavropoulos - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective
Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play a significant role in suppressing autoimmune responses and preventing autoimmunity.

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Osteoarthritis of the Spine

Osteoarthritis of the Spine | Rheumatology-Rhumatologie | Scoop.it

An introduction to osteoarthritis. This overview includes osteoarthritis symptoms and options for osteoarthritis treatment.

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Genome-Wide Association Study Identifies IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis - Julià - Arthritis & Rheumatology - Wiley Online Library

Genome-Wide Association Study Identifies IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis - Julià - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it

Objective: Rheumatoid Factor (RF) is a well established diagnostic and prognostic biomarker in Rheumatoid Arthritis (RA). However, approximately 20% of RA patients do not express this anti-IgG antibody.

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Immunology of the Rheumatoid Joint

Immunology of the Rheumatoid Joint | Rheumatology-Rhumatologie | Scoop.it

This animation guides us through the immune pathways involved in the disease, from the first signs of self-reactive immune cells to joint damage and other symptoms.

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Case study: management and counselling of a patient with rheumatoid arthritis

Case study: management and counselling of a patient with rheumatoid arthritis | Rheumatology-Rhumatologie | Scoop.it

Exploring questions to be considered when managing a patient with rheumatoid arthritis.

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Arthritis Research & Therapy | Full text | B-cell and T-cell quantification in minor salivary glands in primary Sjögren’s syndrome: development and validation of a pixel-based digital procedure

Evaluating lymphocytic infiltration of minor salivary gland biopsy in primary Sjögren’s syndrome is challenging. We developed and evaluated a digital method for quantifying B and T lymphocytes in whole minor salivary gland biopsy slides.

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The Patient with Dry Eyes and Dry Mouth | Rheumatology | Education Lab | CME

The Patient with Dry Eyes and Dry Mouth | Rheumatology | Education Lab | CME | Rheumatology-Rhumatologie | Scoop.it

Education Lab | CME | Sjӧgren's syndrome, characterized by keratoconjunctivitis sicca and xerostomia, is an autoimmune condition with an overlap with lupus, rheumatoid arthritis and mixed collagen vascular syndrome.

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Arthritis Research & Therapy | Full text | A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis

Studies of Caucasian patients with rheumatoid arthritis (RA) to identify genetic biomarkers of anti-tumor necrosis factor (TNF) response have used response at a single time point as the phenotype with which single nucleotide polymorphism (SNP)...

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