Rheumatology-Rhumatologie
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Baicalin inhibits IL-17-mediated joint inflammation in murine adjuvant-induced arthritis. [Clin Dev Immunol. 2013] - PubMed - NCBI

Yang X, Yang J, Zou H.

Abstract

T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo. Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.


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chinese medicine active on Th17 cells?

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RHUMATOLOGIE - RHEUMATOLOGY

Obviously a topic of interest for so many people:

for the patient, it includes aching muscles, tendons and joints..

for MDs and researchers, it covers degenerative diseases as well as arthritis, often associated with various autoimmune diseases (see autoimmunity http://www.scoop.it/t/autoimmunity)

fortunately,

new diagnostic tools are available

and new biotherapies allowed to improve the prognosis and the quality of life of patients

Gilbert C FAURE's insight:

January 2016

still few viewers (#650) for this topic, but >1280 posts and 2000 views

much less than other immunology topics, but growing!

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Clinical and regulatory perspectives on biosimilar therapies and intended copies of biologics in rheumatology - Springer

Clinical and regulatory perspectives on biosimilar therapies and intended copies of biologics in rheumatology - Springer | Rheumatology-Rhumatologie | Scoop.it
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Avoiding Antimalarial Toxicity - Rosenbaum - Arthritis & Rheumatology - Wiley Online Library

Avoiding Antimalarial Toxicity - Rosenbaum - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Unexplained lower back pain? It could be ankylosing spondylitis

Unexplained lower back pain? It could be ankylosing spondylitis | Rheumatology-Rhumatologie | Scoop.it
Roughly a quarter of patients under 45 years suffering ongoing lower-back pain without an obvious other cause will have the disease ankylosing spondylitis.
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Immunoglobulin G4–Related Disease: Retrospective Analysis of 166 Patients - Sekiguchi - Arthritis & Rheumatology - Wiley Online Library

Immunoglobulin G4–Related Disease: Retrospective Analysis of 166 Patients - Sekiguchi - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
Objective: We aimed to investigate clinical and pathologic aspects of immunoglobulin (Ig) G4-related disease (IgG4-RD) in non-Asian populations.
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Family history of rheumatoid arthritis: an old concept with new developments : Nature Reviews Rheumatology : Nature Publishing Group

Family history of rheumatoid arthritis: an old concept with new developments : Nature Reviews Rheumatology : Nature Publishing Group | Rheumatology-Rhumatologie | Scoop.it
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Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis - Ridley - 2016 - Arthritis & Rheumatology - Wile...

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis - Ridley - 2016 - Arthritis & Rheumatology - Wile... | Rheumatology-Rhumatologie | Scoop.it
Objective
In the spondyloarthritides (SpA), increased numbers of CD4+ T cells express killer cell immunoglobulin-like receptor 3DL2 (KIR-3DL2).
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Investigation of Enthesopathy with Ultrasonography and Comparison with Skin Findings in Asymptomatic Psoriatic Patients

Background: Joint involvement associated with psoriasis is referred to as psoriatic arthritis.
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Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis | Rheumatology-Rhumatologie | Scoop.it
Objective
To update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA).
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Heat Shock Proteins (HSP) and Molecular Chaperones

Heat Shock Proteins (HSP) and Molecular Chaperones | Rheumatology-Rhumatologie | Scoop.it
Heat Shock Proteins (HSP) and Molecular Chaperones Curator: Larry H. Bernstein, MD, FCAP     Report on the VIIth International Symposium on Heat Shock Proteins in Biology & Medicine Stuart K. Calderwood and Lawrence E.
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Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis

Objective
Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage. The mechanisms of bone damage in RA are complex, involving activation of bone-resorbing osteoclasts (OCs) by synoviocytes and Th17 cells.
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Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis - Coates - 2016 - Arthritis & Rheumatology - Wiley Online Library

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis - Coates - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
Objective
To update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA).
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Carpal tunnel syndrome: Guidelines rate evidence for diagnosis, treatment : Rheumatology News

Carpal tunnel syndrome: Guidelines rate evidence for diagnosis, treatment : Rheumatology News | Rheumatology-Rhumatologie | Scoop.it
The American Academy of Orthopaedic Surgeons has adopted clinical practice guidelines that assign evidence-based ratings for common strategies used to diagnose
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miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis - Sharma - 2016 - Medicinal Research Reviews - Wiley Online Library

miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis - Sharma - 2016 - Medicinal Research Reviews - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Articular cartilage: from formation to tissue engineering - Biomaterials Science (RSC Publishing)

Hyaline cartilage is the nonlinear, inhomogeneous, anisotropic, poro-viscoelastic connective tissue that serves as friction-reducing and load-bearing cushion in synovial joints and is vital for mammalian skeletal movements.
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Polyarthritis as a rare presentation of hydroxyapatite deposition disease - Aslam - Arthritis & Rheumatology - Wiley Online Library

Polyarthritis as a rare presentation of hydroxyapatite deposition disease - Aslam - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome - Nocturne - 2016 - Arthritis & Rheumatology - Wiley Online Library

Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome - Nocturne - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
Objective
To define parameters predictive of lymphoma development in patients with primary Sjögren's syndrome (SS).
Methods
A multicenter case–control survey was performed to identify predictors of lymphoma.
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Resolvin D1 ameliorates inflammatory arthritis in mouse model

Rheumatoid arthritis (RA) is a debilitating autoimmune disorder that is characterized by the accumulation of inflammatory cells within the fluid of the joints.
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Influenza and Pneumococcal Vaccination Uptake in Patients with Rheumatoid Arthritis Treated with Immunosuppressive Therapy in the UK: A Retrospective Cohort Study Using Data from the Clinical Pract...

Influenza and Pneumococcal Vaccination Uptake in Patients with Rheumatoid Arthritis Treated with Immunosuppressive Therapy in the UK: A Retrospective Cohort Study Using Data from the Clinical Pract... | Rheumatology-Rhumatologie | Scoop.it
Introduction Guidelines for the management of rheumatoid arthritis (RA) recommend using influenza and pneumococcal vaccinations to mitigate infection risk. The level of adherence to these guidelines is not well known in the UK.
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Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells: Immunity

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells: Immunity | Rheumatology-Rhumatologie | Scoop.it
Highlights •SFB enhance autoimmune arthritis, reflected by elevated auto-Ab, GC, and Tfh cell responses •SFB-driven differentiation and egress of PP Tfh cells to systemic sites cause disease •SFB induce PP Tfh cell differentiation by limiting the access of IL-2 to PP CD4+ T cells •DCs are required for SFB-mediated IL-2Rα suppression and Bcl-6 upregulation in PPs
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filamentous?
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Sarcopenia, which affects up to 20 percent of European seniors, may increase 63 percent by 2045

Sarcopenia, which affects up to 20 percent of European seniors, may increase 63 percent by 2045 | Rheumatology-Rhumatologie | Scoop.it
Sarcopenia is a disease associated with the ageing process. Hallmark signs of the disorder are loss of muscle mass and strength, which in turn affects balance, gait and overall ability to perform tasks of daily living.
Gilbert C FAURE's insight:
major challenge of the future
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Perturbed mucosal immunity and dysbiosis accompany clinical disease in a rat model of spondyloarthritis

Objective
The HLA-B27/β2 microglobulin (β2m) transgenic rat is a leading model of B27-associated spondyloarthopathy and disease is dependent on the presence of intestinal bacteria.
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IL-9 over-expression and Th9 polarization characterize the inflamed gut, the synovial tissue and the peripheral blood of patients with psoriatic arthritis

IL-9 over-expression and Th9 polarization characterize the inflamed gut, the synovial tissue and the peripheral blood of patients with psoriatic arthritis | Rheumatology-Rhumatologie | Scoop.it
Objective: This study was undertaken to investigate the expression and tissue distribution of Th9 related cytokines in patients with psoriatic arthritis (PsA).
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Decreasing crystal-induced consternation: New methods of crystal identification - Rosenthal - Arthritis & Rheumatology - Wiley Online Library

Decreasing crystal-induced consternation: New methods of crystal identification - Rosenthal - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis - Ridley - 2016 - Arthritis & Rheumatology - Wile...

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis - Ridley - 2016 - Arthritis & Rheumatology - Wile... | Rheumatology-Rhumatologie | Scoop.it
Objective
In the spondyloarthritides (SpA), increased numbers of CD4+ T cells express killer cell immunoglobulin-like receptor 3DL2 (KIR-3DL2).
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Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis - Meednu - 2016 - Arthritis & Rheumatology - Wiley Online Library

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis - Meednu - 2016 - Arthritis & Rheumatology - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
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