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Outcome of patients with streptococcal prosthetic joint infections with special reference to rifampicin combinations. - PubMed - NCBI

Outcome of patients with streptococcal prosthetic joint infections with special reference to rifampicin combinations. - PubMed - NCBI | Rheumatology Nation | Scoop.it
BMC Infect Dis. 2016 Oct 13;16(1):568.
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Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study... - PubMed - NCBI

Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study... - PubMed - NCBI | Rheumatology Nation | Scoop.it
Lupus. 2016 Sep 29. pii: 0961203316668417. [Epub ahead of print]
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Real-world effectiveness of anti-TNF switching in psoriatic arthritis: a systematic review of the literature. - PubMed - NCBI

Real-world effectiveness of anti-TNF switching in psoriatic arthritis: a systematic review of the literature. - PubMed - NCBI | Rheumatology Nation | Scoop.it
Clin Rheumatol. 2016 Oct 12. [Epub ahead of print]
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Crystal Structure of the Human Cannabinoid Receptor CB1

Crystal Structure of the Human Cannabinoid Receptor CB1 | Rheumatology Nation | Scoop.it
Summary Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational use. CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. Here, we present the 2.8 Å crystal structure of human CB1 in complex with AM6538, a stabilizing antagonist, synthesized and characterized for this structural study. The structure of the CB1-AM6538 complex reveals key features of the receptor and critical interactions for antagonist binding. In combination with functional studies and molecular modeling, the structure provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids. This enhances our understanding of the molecular basis for the physiological functions of CB1 and provides new opportunities for the design of next-generation CB1-targeting pharmaceuticals.

Via Krishan Maggon
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Krishan Maggon 's curator insight, October 22, 7:22 PM
Cell Volume 167, Issue 3, p750–762.e14, 20 October 2016 

 Crystal Structure of the Human Cannabinoid Receptor CB1 

 Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu, Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B. Laprairie, Edward L. Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A. Hanson, Laura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens, Zhi-Jie Liu 

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Cannabis excess linked to bone thinning | The University of Edinburgh

People who regularly smoke large amounts of cannabis have reduced bone density and are more prone to fractures, research has found.
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The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis. - PubMed - NCBI

Arthritis Res Ther. 2016 Oct 6;18(1):223.
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Rescooped by Liz Ciccio from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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CRISPR Corrects Sickle Cell-Causing Gene in Human Cells | The Scientist Magazine®

CRISPR Corrects Sickle Cell-Causing Gene in Human Cells | The Scientist Magazine® | Rheumatology Nation | Scoop.it
Once implanted in mice, the edited stem cells produced normal hemoglobin.
Via Krishan Maggon
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Beta-blocker use associates with lower prevalence of joint pain and lower opioid requirement in people with osteoarthritis. - PubMed - NCBI

Beta-blocker use associates with lower prevalence of joint pain and lower opioid requirement in people with osteoarthritis. - PubMed - NCBI | Rheumatology Nation | Scoop.it
Arthritis Care Res (Hoboken). 2016 Oct 1. doi: 10.1002/acr.23091. [Epub ahead of print]
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Nanoparticle injections may be future of osteoarthritis treatment | Washington University School of Medicine in St. Louis

Nanoparticle injections may be future of osteoarthritis treatment | Washington University School of Medicine in St. Louis | Rheumatology Nation | Scoop.it
Mouse study shows particles may reduce inflammation, stop destruction of cartilage
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Levi Watkins Jr., M.D. Lecture is Oct. 11

Levi Watkins Jr., M.D. Lecture is Oct. 11 | Rheumatology Nation | Scoop.it
Dr. Kevin B. Johnson will deliver the 15th annual Levi Watkins Jr., M.D. Lecture on Tuesday, Oct. 11. The event will begin at noon in Light Hall, Room 208.
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Scientists Learn More About Psoriasis Development

Scientists Learn More About Psoriasis Development | Rheumatology Nation | Scoop.it
While scientists know that there is some genetic connection that explains why some people develop psoriasis, little is known about any details. However, a
Via Gilbert C FAURE
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Rescooped by Liz Ciccio from Osteoporosis New drugs Review
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Bisphosphonates in multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder – an alternative therapeutic approach

Bisphosphonates in multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder – an alternative therapeutic approach | Rheumatology Nation | Scoop.it
Multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder is a rare inherited progressive skeletal disorder caused by mutations in the matrix metalloproteinase 2 (MMP2) gene.

Via Krishan Maggon
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Omega-3 fatty acid stops known trigger of lupus

Omega-3 fatty acid stops known trigger of lupus | Rheumatology Nation | Scoop.it
A team of MSU researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders.
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The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease. - PubMed - NCBI

The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease. - PubMed - NCBI | Rheumatology Nation | Scoop.it
Clin Rheumatol. 2016 Oct 12. [Epub ahead of print]
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Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study... - PubMed - NCBI

Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study... - PubMed - NCBI | Rheumatology Nation | Scoop.it
Lupus. 2016 Sep 29. pii: 0961203316668417. [Epub ahead of print]
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Rescooped by Liz Ciccio from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis | Rheumatology Nation | Scoop.it
Targeted IL-6 inhibition with sirukumab did not demonstrate efficacy or acceptable safety in patients with active lupus nephritis concomitantly receiving immunosupprsant therapy.
Via Krishan Maggon
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Rescooped by Liz Ciccio from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Immune cell’s role in rheumatoid arthritis

Immune cell’s role in rheumatoid arthritis | Rheumatology Nation | Scoop.it
Investigators supported in part by the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have uncovered a mechanism by which B
Via Krishan Maggon
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Lupus nephritis is associated with more corticosteroid-associated organ damage but less corticosteroid non-associated organ damage. - PubMed - NCBI

Lupus nephritis is associated with more corticosteroid-associated organ damage but less corticosteroid non-associated organ damage. - PubMed - NCBI | Rheumatology Nation | Scoop.it
Lupus. 2016 Sep 29. pii: 0961203316671813. [Epub ahead of print]
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MR-based prognostic nomogram for prostate cancer after radical prostatectomy. - PubMed - NCBI

MR-based prognostic nomogram for prostate cancer after radical prostatectomy. - PubMed - NCBI | Rheumatology Nation | Scoop.it
J Magn Reson Imaging. 2016 Sep 21. doi: 10.1002/jmri.25441. [Epub ahead of print]
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Rescooped by Liz Ciccio from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Gamida Cell's cell therapy treatment gains breakthrough status - Pharmaphorum

Gamida Cell's cell therapy treatment gains breakthrough status - Pharmaphorum | Rheumatology Nation | Scoop.it
Israel’s Gamida Cell's NiCord therapy for patients with high risk blood cancers, has been hailed as a breakthrough by the US regulator.
Via Krishan Maggon
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Study reveals how cells work to keep inflammation in check | UW HSNewsBeat

Study reveals how cells work to keep inflammation in check | UW HSNewsBeat | Rheumatology Nation | Scoop.it
A new study by University of Washington researchers reveals how cells keep inflammation in check by secreting protein antagonists that bind to and block inflammatory signals from white cells.  The findings should help scientists to better understand and develop more effective treatments for a wide variety of inflammatory disorders.
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New Discovery by Researchers May Lead to Better Understanding and Treatment for a Common Autoinflammatory Disease - Stony Brook University Newsroom

New Discovery by Researchers May Lead to Better Understanding and Treatment for a Common Autoinflammatory Disease - Stony Brook University Newsroom | Rheumatology Nation | Scoop.it
News and Media for Stony Brook University
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Rescooped by Liz Ciccio from Cardiologist Connect
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The effect of etanercept on traditional metabolic risk factors for cardiovascular disease in patients with rheumatoid arthritis. - PubMed - NCBI

The effect of etanercept on traditional metabolic risk factors for cardiovascular disease in patients with rheumatoid arthritis. - PubMed - NCBI | Rheumatology Nation | Scoop.it
Clin Rheumatol. 2016 Oct 5. [Epub ahead of print]
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Team watches as fat cells become bone tissue - Futurity

Team watches as fat cells become bone tissue - Futurity | Rheumatology Nation | Scoop.it
Scientists can now watch how human fat cells transform into bone tissue cells. Doing so has uncovered information about osteoporosis in older women.
Via Krishan Maggon
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Rescooped by Liz Ciccio from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Rheumatoid subtypes explored by PheWAS

Rheumatoid subtypes explored by PheWAS | Rheumatology Nation | Scoop.it
A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis.
Via Krishan Maggon
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