Rett syndrome and breathing difficulties
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Serotonin 5-HT1A receptor biased agonist NLX-101 (F15599) elicits distinctive brain activation patterns: a pharmacoMRI study

Serotonin 5-HT1A receptor biased agonist NLX-101 (F15599) elicits distinctive brain activation patterns: a pharmacoMRI study | Rett syndrome and breathing difficulties | Scoop.it
Serotonin 1A (5-HT1A) receptors are involved in several physiological and pathological processes and constitute therefore an important therapeutic target.
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What do breathing problems look like in a Rett Syndrome girl

Read more about what it's like to struggle to breathe at www.magnoliashope.com Share this video: http://on.fb.me/1jLm3YS GoFundMe:

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24 June 2015 - Rett Syndrome Research Trust awards a new research grant to Neurolixis

24 June 2015 - Rett Syndrome Research Trust awards a new research grant to Neurolixis | Rett syndrome and breathing difficulties | Scoop.it

Neurolixis has been awarded a new research grant from the Rett Syndrome Research Trust (RSRT) to advance development of NLX-101, a clinical-phase candidate for treatment of Rett syndrome. NLX-101 has previously been awarded Orphan Drug designation for this indication in both the USA and in the European Union.

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21 April 2015 - Neurolixis CEO to present at World Orphan Drug Congress USA

21 April 2015 - Neurolixis CEO to present at World Orphan Drug Congress USA | Rett syndrome and breathing difficulties | Scoop.it
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Rett syndrome may result from overexpression of long genes

Rett syndrome may result from overexpression of long genes | Rett syndrome and breathing difficulties | Scoop.it
Mutations in the methyl CpG binding protein 2 gene (MECP2) are the cause of the devastating childhood neurological disorder Rett Syndrome. Despite intense efforts spanning several decades the precise function of MECP2 has been difficult to pin down.
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Obama Seeks Millions for 'Precision Medicine' targeting genetic disorders

Obama Seeks Millions for 'Precision Medicine' targeting genetic disorders | Rett syndrome and breathing difficulties | Scoop.it

President Barack Obama is asking Congress for $215 million to pay for what he's calling a Precision Medicine Initiative — a plan to rev up more targeted medical treatments - NBCNews.com

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Transgenic monkey missing Rett syndrome gene prompts primate research debate at SfN

Transgenic monkey missing Rett syndrome gene prompts primate research debate at SfN | Rett syndrome and breathing difficulties | Scoop.it
A marmoset monkey model of Rett syndrome is revealed in SfN. Monkey missing Rett gene prompts primate research debate http://t.co/7KR0VWPOqa
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Neuren's NNZ-2566 successful in showing clinical benefit in Rett Syndrome ... - Pharmaceutical Business Review

Neuren Pharmaceuticals has announced top-line results from its US Phase II clinical trial in Rett syndrome, demonstrating clinical benefit

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Rett Syndrome Foundation - research porfolio overview with Steve Kaminsky, CSO

Steve Kaminsky, International Rett Syndrome Foundation, Chief Science Officer. As CSO, Dr. Kaminsky oversees Rettsyndrome.org’s research portfolio.


Via Tommy Lawson
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Serotonin neurones have anti‐convulsant effects and reduce seizure‐induced mortality

Serotonin neurones have anti‐convulsant effects and reduce seizure‐induced mortality | Rett syndrome and breathing difficulties | Scoop.it

Serotonin: new evidence serotonin controls seizure threshold and reduces death from respiratory arrest. http://t.co/WIVrBpLwhx mouse study

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Rett Syndrome MeCP2 gene dysfunction redefined

Rett Syndrome MeCP2 gene dysfunction redefined | Rett syndrome and breathing difficulties | Scoop.it

Researchers have discovered that the protein product of the gene MECP2, which is mutated in about 95% of Rett syndrome is a global activator of neuronal gene expression. Mutations in the protein can cause decreased gene transcription, reduced protein synthesis, and severe defects in the AKT/mTOR signaling pathway.

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The Ice Bucket Challenge for Rett Syndrome

In this video I decided to start something that will hopefully raise awareness for Rett Syndrome. My baby cousin has it which prompted me to do this after I saw how the ALS Ice Bucket Challenge...
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Rett syndrome research – What's happening

Rett syndrome research – What's happening | Rett syndrome and breathing difficulties | Scoop.it
Dr Julian Paton's, University of Bristol, a preclinical breathing study into NLX-101 from Neurolixis, which is being part funded by Cure Rett through Rettsyndrome.org. Dr Paton's study tackles an often overlooked area of Rett ...
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Rett Syndrome Research Trust Awards $9 Million to Accelerate Translation of Lab Discoveries to the Clinic

Today the Rett Syndrome Research Trust (RSRT) announced research awards totaling nearly $9 million in 2015. This is the most research ever awarded in a given year by any Rett Syndrome organization.
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In mice, experimental drug treatment for Rett syndrome suggests the disorder is reversible

In mice, experimental drug treatment for Rett syndrome suggests the disorder is reversible | Rett syndrome and breathing difficulties | Scoop.it
A team at Cold Spring Harbor Laboratory (CSHL) has developed a strikingly new approach for treating Rett syndrome, a devastating autism spectrum disorder (ASD) that affects 1 in 10,000 people in the US, mostly girls.
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New studies contradict earlier findings on Rett syndrome

New studies contradict earlier findings on Rett syndrome | Rett syndrome and breathing difficulties | Scoop.it

Bone marrow transplant does not rescue mouse models of Rett syndrome, a severe neurological disease, a new study shows. The findings contradict seemingly promising presults previously published by another laboratory.

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Rett Syndrome Research Trust Awards $1.3 Million For Ketamine Clinical Trial

Rett Syndrome Research Trust Awards $1.3 Million For Ketamine Clinical Trial | Rett syndrome and breathing difficulties | Scoop.it
Researchers are hoping to learn if low doses of ketamine can reverse the debilitating disease.
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Rett Syndrome Research Trust Awards $5.8 Million to Advance the Development of Treatments and Cures for Rett Syndrome and MECP2 Disorders

Rett Syndrome Research Trust Awards $5.8 Million to Advance the Development of Treatments and Cures for Rett Syndrome and MECP2 Disorders | Rett syndrome and breathing difficulties | Scoop.it
Trumbull, CT (PRWEB) February 03, 2015 -- Today the Rett Syndrome Research Trust (RSRT) announced research investments of $5.8 million awarded in 2014. RSRT’s sole and urgent goal is to abolish Rett Syndrome and related disorders.
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Identification of a Serotonin Neuron Subtype That Regulates Breathing Dynamics

Identification of a Serotonin Neuron Subtype That Regulates Breathing Dynamics | Rett syndrome and breathing difficulties | Scoop.it
Adrian Newman-Tancredi's insight:

The life-sustaining respiratory CO2 chemoreflex is regulated by a specialized subtype of serotonergic neuron - the Egr2-Pet1 subtype.

http://www.cell.com/cell-reports/abstract/S2211-1247%2814%2900993-0

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Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome

Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome | Rett syndrome and breathing difficulties | Scoop.it

PNAS vol. 111 no. 12 4596–4601, doi: 10.1073/pnas.1311141111

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Rett Syndrome: Why Girls?

Rett Syndrome: Why Girls? | Rett syndrome and breathing difficulties | Scoop.it
by Monica Coenraads.
“ Anyone who knows anything about Rett Syndrome knows that the disorder is primarily seen in girls. The disorder is caused by disruption of the MECP2 gene located on the X...
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Table summarizing strategies to treat Rett Syndrome - Rett Syndrome Research Trust

Ongoing research efforts to treat and cure Rett Syndrome.

Via Tommy Lawson
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Rousing silenced X chromosome may treat Rett syndrome - SFARI News

Rousing silenced X chromosome may treat Rett syndrome - SFARI News | Rett syndrome and breathing difficulties | Scoop.it

Drugs that activate the silent copy of the X chromosome in women may be able to undo the damage from mutations in genes located there. The study offers hope for treating Rett syndrome and other disorders linked to the X chromosome.

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Edison's orphan drug misses the mark in Phase II - FierceBiotech

Edison's orphan drug misses the mark in Phase II - FierceBiotech | Rett syndrome and breathing difficulties | Scoop.it

Edison's orphan drug misses the primary end-point in Phase II.

The drug, EPI-743, is an oral therapy designed to treat disorders of energy metabolism, including Rett syndrome, a neurodevelopmental disorder that affects one in every 10,000 to 15,000...

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Rettsyndrome.Org awards $1.5M to advance translational research programs

Rettsyndrome.Org awards $1.5M to advance translational research programs | Rett syndrome and breathing difficulties | Scoop.it

Rettsyndrome.Org awards $1.5M to advance translational research, programs

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