A new paper in the Proceedings of the National Academy of Sciences shows that the epistatic network in fruit flies can be used to predict variation in quantitative genetic traits -- those controlled by multiple genes.
A team of researchers at NC State University published the paper, for which Dr. Trudy Mackay, Wm. Neal Reynolds and Distinguished University Professor of Genetics, is the corresponding author.
The paper bolsters the effort to predict how genes affect physical or behavioral traits through the genotype-phenotype map. Understanding how genes interact in the process known as epistasis would move the effort closer to the goal.
The effects of these gene-gene interactions ... are difficult to gauge in human populations because some variations are unknown, says Dr. Trudy Mackay.
The pnas paper can be found here: