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Scientists Clone Embryonic Stem Cells From Adult Skin - American Live Wire

Scientists Clone Embryonic Stem Cells From Adult Skin - American Live Wire | Regenerative Medicine | Scoop.it
iScienceTimes.com Scientists Clone Embryonic Stem Cells From Adult Skin American Live Wire For the first time, United States researchers have cloned embryonic stem cells from their original adult cells, a scientific breakthrough on the road toward...
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somatic cell nuclear transfer (SCNT) replicated!

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Tissue engineered vagina's function normally over eight years - Next Big Future

Tissue engineered vagina's function normally over eight years Next Big Future “Tissue biopsies, MRI scans and internal exams using magnification all showed that the engineered vaginas were similar in makeup and function to native tissue, said...
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WFIRM generates lab-grown sex organs!

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3-D Printing Blood Vessels into Artificial Tissues Could Eliminate Need for Donor Organs | MIT Technology Review

3-D Printing Blood Vessels into Artificial Tissues Could Eliminate Need for Donor Organs | MIT Technology Review | Regenerative Medicine | Scoop.it
Artificial tissue has always lacked a key ingredient: blood vessels. A new 3-D printing technique seems poised to change that. (RT @MosesFeaster: What's artificial blood w/o artificial blood vessels?

Via Jacob Blumenthal
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3-D printing combining blood vessels & cell! A powerful combination.

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Jacob Blumenthal's curator insight, April 20, 2014 11:28 AM

A team of Harvard researchers have created a tissue interlaced with blood vessels. "The tissue is the first made through 3-D printing to include potentially functional blood vessels embedded among multiple, patterned cell types".

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BioCision's Proprietary Temperature Standardization Technology to be used in ... - PR Newswire (press release)

BioCision's Proprietary Temperature Standardization Technology to be used in ...
PR Newswire (press release)
... Cell Therapy Clinical Trial in the Treatment of Crohn's Disease.
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Developing tools for standardization is key for moving research forward towards commercialization....

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Bulletproof vests from stem cells ? - Odisha Sun Times

Bulletproof vests from stem cells ? - Odisha Sun Times | Regenerative Medicine | Scoop.it
Bulletproof vests from stem cells ?
Odisha Sun Times
In a first, scientists have discovered a new property in the nuclei of embryonic stem cells that could pave way for wider application of the body's master cells, including bulletproof vests.
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Interesting finding that could be expand applications for stem cells... 

http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat3943.html

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GEN | News Highlights:Lab-Grown Vaginas a Success, Years after Patient Implantation

GEN | News Highlights:Lab-Grown Vaginas a Success, Years after Patient Implantation | Regenerative Medicine | Scoop.it
The first human recipients of lab-grown vaginas, after a number of annual followup evaluations, report normal sexual function, including desire and pain-free intercourse.

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Lab-grown sex organs provide treatments.

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Jacob Blumenthal's curator insight, April 12, 2014 11:14 AM

Researchers led by Anthony Atala, M.D., director of Wake Forest Baptist Medical Center’s Institute for Regenerative Medicine, have developed a novel tissue engineering approach of engineering vaginal organs in the lab. The engineered vaginas were implanted in 4 women that were born with a rare form of vaginal aplasia, Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.  In order to engineer the vaginas, the researchers grew cells on 3D biodegradable scaffolds, that upon transplantation allowed the entrance of blood vessels and nerve cells from the recipient's body into the scaffold. Now, after several years of follow up visits, the researchers conclude that these implants can be used successfully in human beings.

To the paper:  http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60542-0/abstract

 

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GEN | Magazine Articles: Aubrey de Grey: Out to Defy Death

GEN | Magazine Articles: Aubrey de Grey: Out to Defy Death | Regenerative Medicine | Scoop.it

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Jacob Blumenthal's curator insight, March 27, 2014 1:32 AM

What is the worst problem in the world? According to Aubrey de Grey, a biomedical gerontologist, its AGING. He is the founder of SENS, a research foundation that aims to help build the regenerative medicine industry. According to his view, one of he ways to deal with cell loss, or cell atrophy during aging is by using stem cells and tissue engineering strategies.

Join my Facebook group for more news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

For more, check out Liz Parrish  podcast with Aubrey here:  https://itunes.apple.com/us/podcast/biotrove-podcasts-biotrove/id827618919?mt=2

 

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New stem cell technique bypasses ethical concerns

New stem cell technique bypasses ethical concerns | Regenerative Medicine | Scoop.it
Stem cell and cloning research using human cells remain controversial, even though it is nearly 20 years since Dolly the sheep became the first mammal to be cloned. One of the main reasons for this controversy…

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Jacob Blumenthal's curator insight, March 27, 2014 4:51 PM

In a new paper, published in Nature, researchers led by Shoukhrat Mitalipov, have demonstrated a novel nuclear reprogramming technique in mice. Until now, unfertilized eggs were needed for cell cloning by nuclear reprogramming. In the new technique, the researchers used fertilized eggs at the stage of interphase, just after the first cell division. They injected nuclei of two non-reproductive cells into both cells of the two-cell embryo that has just undergone its first cell division. During this stage, the conditions allowed formation of embryonic stem cells or even a clone. If these results could be reproduced in human, it will allow to generate stem cells from any person, without the need to destroy embryos, as in the case of human embryonic stem cells.

Paper: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13134.html

 

Learn more about stem cells and their differentiation protocols: 

http://discovery.lifemapsc.com/stem-cell-differentiation

 

 

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Family Guy -- Why Are We Not Funding This (Stem Cell Research) - YouTube


Via Jacob Blumenthal
Joshua Hunsberger's insight:

I ask myself the same question. Why are we not providing more funding for Stem Cell Research. The potential is there to deliver cures. 

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Jacob Blumenthal's curator insight, April 2, 2014 7:17 AM

A nice animation on YouTube :)

 

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Stem cell-derived pancreatic cells treat diabetes in mice

Stem cell-derived pancreatic cells treat diabetes in mice | Regenerative Medicine | Scoop.it

Sanford-Burnham Medical Research Institute (Sanford-Burnham) and UC San Diego School of Medicine researchers have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESCs), and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs of the technology.
P


Via Ella Buzhor
Joshua Hunsberger's insight:

Encapsulating immature pancreatic cells may prove useful for treating diabetes.

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Ella Buzhor's curator insight, March 27, 2014 9:02 AM

The TheraCyte™ is a thin membrane bound polymeric chamber, designed to encapsulate and protect allogeneic cells from rejection by the recipient and, when implanted subcutaneously, induce the development of blood capillaries close to the membranes. ESC-derived islet progenitors encapsulated is this envelope and transplanted into mice demonstrated insulin secretion levels  sufficient to ameliorate alloxan-induced diabetes.

http://www.sciencedirect.com/science/article/pii/S1873506114000300?via=ihub

 
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Regenerative Medicine Essentials - Wake Forest School of Medicine

Regenerative Medicine Essentials - Wake Forest School of Medicine | Regenerative Medicine | Scoop.it
Regenerative Medicine Essentials









Often referred to as the next evolution of modern health care, regenerative medicine touches many disciplines - from clinical care and engineering to basic science and bioethics.
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New course on Regenerative Medicine worth checking out!

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Tissue Engineering & Cell Therapy | Global Markets | HealthWorks Collective

Tissue Engineering & Cell Therapy | Global Markets | HealthWorks Collective | Regenerative Medicine | Scoop.it
The market for tissue engineering and cell therapy products is set to grow from a respectable $8.3 billion in 2010 to nearly $32 billion by 2018.
Joshua Hunsberger's insight:

From $8.3 Billion (2010) to $32 Billion (2018, projected)! The market for Tissue Engineering & Cell Therapy Products is exploding!

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Aastrom Announces Definitive Agreement to Acquire Sanofi's Cell Therapy and ... - Benzinga

Aastrom Announces Definitive Agreement to Acquire Sanofi's Cell Therapy and ... - Benzinga | Regenerative Medicine | Scoop.it
Aastrom Announces Definitive Agreement to Acquire Sanofi's Cell Therapy and ...
Benzinga
Through the CTRM acquisition, Aastrom is acquiring global commercial rights to three marketed autologous cell therapy products.
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Aastrom gaining speed in the field of Regenerative Medicine!

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New Initiative Could Ban Funding Of Embryonic Stem Cell Research In Europe - Forbes

New Initiative Could Ban Funding Of Embryonic Stem Cell Research In Europe - Forbes | Regenerative Medicine | Scoop.it
Forbes
New Initiative Could Ban Funding Of Embryonic Stem Cell Research In Europe
Forbes
One of Us, a so-called European citizens' initiative, has collected 1.7 million signatures from all 28 E.U.
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This would not be beneficial for the advancement of new therapies developed using embryonic stem cells.... 

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USC Master of Science in Stem Cell Biology and Regenerative Medicine

The Master of Science degree program is the first in stem cell biology and regenerative medicine in California, and one of only three in the U.S. The one-yea...
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New masters program in regenerative medicine at USC!

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Scientific Breakthrough as Artificial Blood is Created from Stem Cells

Scientific Breakthrough as Artificial Blood is Created from Stem Cells | Regenerative Medicine | Scoop.it
Mass production of human blood could become reality as artificial blood is tested on patients for the first time.

Via Jacob Blumenthal
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Artificial Blood is Created from Stem Cells!

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Jacob Blumenthal's curator insight, April 15, 2014 1:24 AM

British researchers have announced that after 4 years of research their Blood Pharma programme has made enough progress turning stem cells into red blood cells to move to clinical trials by late 2016. The researchers use both human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) to generate blood cells in-vitro. They differentiate them into red blood cells, and expand their number in culture. The last differentiation stage is when the  developing blood cells eject their DNA to adopt the enucleated state characteristic of red blood cells.

Learn more about blood development and related stem cell differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/blood

Mick D Kirkov's curator insight, April 16, 2014 1:03 PM

Artificial Blood Is Patient Ready

http://www.the-scientist.com//?articles.view/articleNo/39718/title/Artificial-Blood-Is-Patient-Ready/

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BrainStorm receives US Patent for its autologous stem cell technology | Stem Cells Freak

The U.S. Patent and Trademark Office has granted brainstorm a key patent for its autologous stem cell technology.

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Jacob Blumenthal's curator insight, March 25, 2014 2:13 AM

The company develops NurOwn for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

Read more: http://www.stemcellsfreak.com/2014/03/brainstorm-patent.html#ixzz2wx6N85hW

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RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers

RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers | Regenerative Medicine | Scoop.it
Investigating committee identifies two instances of research misconduct, puts most of the blame on lead author

Via Jacob Blumenthal
Joshua Hunsberger's insight:

I say what can we learn from this and let's move forward.

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Jacob Blumenthal's curator insight, April 1, 2014 12:11 PM

"

From the news : "An investigating committee has concluded that falsification and fabrication mar two recent Nature papers reporting a new, simple way to reprogram mature cells into stem cells. The committee concluded that these acts constitute research misconduct, but it stopped short of calling for the papers to be retracted and will leave the question of disciplinary action to a separate committee. RIKEN President Ryoji Noyori today said he favors the papers’ retraction if the committee’s findings are upheld in an appeals process.

“I am filled with feelings of indignation and surprise,” said lead author Haruko Obokata, of the RIKEN Center for Developmental Biology (RIKEN CDB) in Kobe, in a statement. She wrote that she intends to appeal the judgment".

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Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy

Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy | Regenerative Medicine | Scoop.it
Drosophila intestines provide 'ready-made stem cell microenvironments' that are 'difficult-to-impossible' to create in petri dishes, offering an unconventional screen that allows researchers to tes...

Via Ella Buzhor
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Demonstrates the importance of screening in whole animals and why considerations should be made for the effects of drugs on more than one cell type and microenvironments.

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Ella Buzhor's curator insight, March 12, 2014 3:54 AM

Some chemotherapy drugs have the dual property of reducing growth of stem-cell–derived tumors while also stimulating hyperproliferation of their wild-type counterparts, contributing to tumor recurrence. This side effect is mediated  by activation of the JAK-STAT inflammatory pathway, meaning that supplementing traditional chemotherapy with anti-inflammatory treatment may reduce tumor recurrence. 

http://www.pnas.org/content/early/2014/03/06/1401160111

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First comprehensive atlas of human gene activity released - A new road map for direct cell reprogramming?

First comprehensive atlas of human gene activity released - A new road map for direct cell reprogramming? | Regenerative Medicine | Scoop.it
A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body. The findings describe the complex networks that govern gene activity, and the new information could play a crucial role in identifying the genes involved with disease.

Via Jacob Blumenthal
Joshua Hunsberger's insight:

This is definitely worth investigating!

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Jacob Blumenthal's curator insight, March 29, 2014 2:39 AM

This new map of gene activity in cells and tissues, may serve as a road map for direct reprogramming of somatic cells. Knowing the master regulators, key genes for each lineage is crucial in order to perform efficient reprogramming.

Overall, it brings us closer to the times when researchers will be able to generate mature cells for regenerative medicine purposes from the patient's own cells, without the need to generate fully pluripotent stem cells.

Interested in tissue/organ specific gene expression? check the LifeMap Discovery database:  http://discovery.lifemapsc.com/in-vivo-development