Montappone is a medieval town nestled in one of the most beautiful regions of Italy: Marche. There dictates the rules of an accessory which recently returned very fashionable: the hat.... In this municipality, supported by five others in the neighborhood, there are over 40 craft enterprises, which continue the family tradition. To give you an idea, factories in the area are 70% of the production of straw hats in Italy and 50% in Europe. [...]
"Violence has a geography and for this reason, geography lies at the center of discussions of violence. Within the United States a myriad of taken for granted assumptions about identity, place, power, and memory undergird the nation’s psyche. These normative interpretations intersect with a particular kind of geographic formulation that places persons of color in general, but black men most specifically, at the center of the violent structures of the nation."
From why she doesn't take sexy selfies to why she dances at awards shows, here's what didn't fit into Taylor Swift's third Rolling Stone cover story (RT @taylorswift13: Real talk: http://t.co/MLIbdFBJ8C)...
Former Real Madrid general director Jorge Valdano launches scathing attacking on Jose Mourinho, claiming he pales in comparison to Pep Guardiola (Jose Mourinho will never be as good as Pep Guardiola, claims former Real Madrid chief Jorge Valdano
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Step aside Olympians – the new sporting pursuit of choice may soon be professional gaming. Electronic sports (or esports) are now mainstream, drawing more than a million viewers in large tournaments and…
Comic Book Resources High marks for Monte Beauchamp's 'Masterful Marks' Comic Book Resources Certainly Disney and Osamu Tezuka qualify, as do Jerry Siegel and Joe Shuster, who introduced the superhero as we know it, and Jack Kirby, who reimagined...
Essentially, Augmented Reality is hidden content, most commonly hidden behind marker images, that can be included in printed and film media, as long as the marker is displayed for a suitable length of time, in a steady position for an application (on a device such as a tablet or smartphone, by means of a camera) to identify and analyse it.
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Apple has announced that Swift 1.0 has reached GM status on iOS and developers can now start submitting apps that use Swift. The language will continue to evolve, say Apple, as it has done since its announcement at WWDC 2014 last June. This is a short summary of its evolution.
In step one, look at the “big picture” and ask yourself who you want to target. Are you looking for net new prospects, to cross sell/upsell existing customers, or even re-engage past customers? Create buyer scenarios detailing out personal information, buying behaviors and other essential information.
2. Pilot Design
Step two: pilot design. With a thorough understanding of the prospect base you can begin to create an implementation plan moving forward. Within the implementation plan you will need to develop tailored messaging for each audience. Messaging frameworks that highlight individual value propositions, pain points, and buying behaviors will assist in building a meaningful relationship with prospects by offering them engaging content.
3. Campaign Development
Step three: campaign design. With your segmented messaging and implementation plan in place, you can begin to prepare best-in-class customer communications to provide your audience(s) with targeted content for amplified engagement.
4. Execution and Measurement
Step four: execution and measurement. In this phase, leverage your implementation plan and communications calendar to ensure timely and flawless execution of the pilot program.
Finally, step five, optimization. The optimization phase permits the opportunity to take key learnings from the nurture engine pilot and make recommendations to improve the program before the broader roll out. Take pilot learnings to refresh content, creative and make broader campaign recommendations. Apply learnings to iterative campaign waves to ensure success and a high return on investment.
As we move into the last few days of the referendum campaign, I wonder if there is much more to say. Surely, with all the millions of words that have been written, everything that might be said on the matter has already been said many times over. The lies of the No campaign have been exposed. Their scare stories have all been comprehensively debunked. The manifold positive arguments for independence have been stated and restated in every way imaginable.
Via Peter A Bell
We’ve written about states’ “right to try” laws, which expand desperate patients’ power to use drugs before the FDA approves them. These laws, gaining bipartisan approval in a growing number of states, open up the question of whether FDA powers that limit the availability of new medicines can be challenged by states.
The problem that “right to try” laws address is that patients who have no alternative treatment, except an experimental medicine, are often willing to take more risk than the FDA appreciates. They want the FDA out of the way and are not satisfied with federal policies that expand access to experimental medicines.
Pharmaceutical executives whom I have questioned assert that “right to try” laws are naive. In one sense they are: I have yet to identify a drug-maker that is supplying medicines under the auspices of a “right to try” law. The problem for a drug-maker with a unique new medicine for a deadly illness that strikes a small population is that every patient who takes the drug on an experimental basis is one less patient who can be enrolled in a randomized, double-blind clinical trial — the “gold standard” demanded by the FDA for approval.
A couple of pharmaceutical executives have written a very honest article about their experience dealing with a request for compassionate use of an experimental drug, while one of them was CEO of the company that was developing it.
Brincidofovir is an anti-viral drug designed for patients who receive stem-cell tranfusions for bone marrow or immune system failure. For a short time, the company (Chimerix) provided the unapproved medicine under a government arrangement that investigated its use against smallpox. However, when that ended, the company stopped approving requests for compassionate use, anxious that it would not be able to complete its necessary trials.
What is interesting is that the company changed its mind as a result of one family’s social-media campaign — not a change in law or regulation. The company was on the receiving end of such vilification that it pressured the FDA to find a way to allow compassionate use.
Also interesting is that the company’s stock jumped 50 percent once it started distributing the drug on a compassionate basis. The stock market, being a market, has a more accurate view of the value of the new medicine than either the company or the FDA (as discussed in an earlier blog entry).
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