of small and medium sized enterprises (SMEs) will be affected. As the first registration phase focused on substances produced or imported in high volumes, smaller companies have not been as involved in the Reach process as some of the larger companies. However, this is about to change. SMEs will have to become more involved in Reach, and most will have little experience of the Reach process. Most likely, they will also have less budget and fewer resources to handle the complexities and administrative challenges involved.