Genome editing using artificial site-specific nucleases in zebrafish - Dev. Growth Diff. | QTL-Seq | Scoop.it

(via T. Schreiber, thx)

Hisano et al, 2013

Zebrafish is a model vertebrate suitable for genetic analysis.

Recently, new gene targeting technologies, such as the transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 systems, have been developed: that can directly introduce genome modifications at the targeted genomic locus. Here, we summarize these new and powerful genome editing techniques for the study of zebrafish.


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