Aspect 2 & 3
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Human Genetic Engineering Con

New Project 4.
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Katherine Shaw's comment, March 28, 2014 11:38 AM
ASPECT 3)- 8- "what if you were told you only had exceptional traits because of a choice your parents made?" totally mistated fact. There is the potential for anything to go bad but that is NOT what gene therapy is about.
Katherine Shaw's comment, March 28, 2014 11:39 AM
ASPECT 3) 9- "Do you wish for no individuality"- once again a totally misunderstood statements since this is not what gene therapy treats.
Katherine Shaw's comment, March 28, 2014 11:42 AM
ASPECT 3) 10- the main point behind this video is that most of the moral and ethical issues behind gene therapy are because this form of medicine is extremely misunderstood. If people understood the facts and purpose behind gene therapy most issues would be resolved. There will still be people against it however if more people are informed and know the right information it would be more accepted.
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Pros and Cons | Gene Therapy

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Katherine Shaw's comment, March 28, 2014 11:23 AM
ASPECT 3) 4- Since gene therapy permantely alters the genetic make up of a patient's body there is no guarantee the long term affects. Since most trials have been done in recent years, the lasting affects it has on the body is unknown.
Katherine Shaw's comment, March 28, 2014 11:27 AM
ASPECT 3) 5- The main fear of gene thearpy, as moral reasons go, is the fear that we can take gene therapy too far. Altering future generations and creating "designer babies" with certain genes are all fears many have with gene therapy. Also, there is a great fear of wiping out illnesses that cause natural selection to take place.
Katherine Shaw's comment, March 28, 2014 11:28 AM
*heavily biased to the cons*
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Dr. Max Gomez: Gene Therapy Could Be Lifesaver For Cancer Patients - CBS Local

Dr. Max Gomez: Gene Therapy Could Be Lifesaver For Cancer Patients - CBS Local | Aspect 2 & 3 | Scoop.it
AFP
Dr. Max Gomez: Gene Therapy Could Be Lifesaver For Cancer Patients CBS Local “The approach that we've taken is to take a patient's immune cells out of their body and use gene therapy technology to redirect the immune cells to recognize the...
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Katherine Shaw's comment, March 5, 2014 11:23 AM
5) Paolo Cavalli was a leaukima patient for about six years. He had been through as many treatments as doctors thought were possible to try to cure the cancer but he continued to relapse despite their efforts. When he was told there was nothing else the doctors could do he refused to give up. He volunteered for a gene therapy trial at Memorial Sloan-Kettering Cancer Center- what did he have to loose? he thought.
Katherine Shaw's comment, March 5, 2014 11:26 AM
6) Gene therapyis used to direct a patients cells to attack the cancer like it would any other disease. This type of gene therapy worked in 88% of trial patients, including Paolo Cavalli. This is huge and could be used to help fight all different types of cancer.
Katherine Shaw's comment, March 5, 2014 11:26 AM
7) "White blood cells called T-cells are taken from the patient, then a virus is used to insert a gene into the cells which tells the T-cells to make a receptor that attaches to markers on the surface of cancer cells allowing the T-cells to kill the cancer." (CITE)
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Gene therapy breakthrough in cancer treatment

An experimental gene therapy is showing high rates of success with cancer patients who have failed to respond to traditional treatments. Jim Axelrod reports.
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Katherine Shaw's comment, March 26, 2014 10:57 AM
14) adults and 19 children have reached full remission from cancer during this trial
Katherine Shaw's comment, April 9, 2014 11:32 AM
13) adults and 19 children have reached full remission from cancer during this trial
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OJHAS: 2002-2-1 Ananth N, Gene Therapy: Potential, Pros/Cons And Ethics

OJHAS is India's first, online-only, peer reviewed, open access, biomedical journal; now archived in Cogprints
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Katherine Shaw's comment, March 28, 2014 11:29 AM
ASPECT 3) 6- Gene therapy is a misunderstood form of medicine. Many people fear that we are altering the human race, however, "gene therapy simply takes advantage of the human body's ability to produce its own cure more quickly, safely and effectively than can be done in a lab"
Katherine Shaw's comment, March 28, 2014 11:31 AM
ASPECT 3) 7- " Genetic technology poses risks along with its rewards, just as any technology has in the past. To stop its development and forfeit the benefits gene therapy could offer would be a far greater mistake than forging ahead could ever be. "
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Interview Results

Interiview Q&A

Katherine Shaw's insight:

1) What do you do?

- I do a lot of studies and clinical trials in gene therapy dealing with arthritis.

 

2) How did you come to work in this field?

- Degree in genetics, working in medical school, late 1980's

 

3) Future direction for gene therapy...changes in the next years?

- It is mixed because the trials go up and down. Every time they hve some successes a patiend dies and send it ack down to being studied.

 

4) What medical fields/ diseases is there a future for?

- Cancer, arthritis, regenerative, (after heart attacks, pancreas from diabetes, etc.)

 

5) Advice for getting into this work..coursework...internships...degress?

- Go into college with a Pre-med degree so you hvave your under graduate--then getting into a PhD program would be good because you would gain a science knowlewge on top of your medical background. It is a lot easier to get into gene therapy these days because it is a well-known field. (When he started into this field in the 1980's it was an unknown field and was not as easy and straighforwasrd intot getting into)

 

6) What are some successes?

-Bubble boy-not just using bone marrow but able to use gene therapy

eye disease

hemophilia

 

7) What are some risks and failures from gene therapy?

- Illnesses

cancer

price

viruses kill 

 

8) How does gene therapy work?

-They use virsus to insert gene into people's bodies. You can easily tell from getting the flu, viruses sare very efffiecient at inserting their DNA into your body. They are very efficient for using gene therapy because of this reason.

 

9) Is it only trials or used form of medicine?

-Just trials still

 

10) Pros and Cons--- ethical reasons?

- I believe there are no problems with using gene therapy as long as you are not changing what happens to the next genteration. Since gene therapy only modifies body (somatic) cells it has no affect on future generations. There are risks and benefits, but there are for everything, including taking aspirin. No ethical issues at all.

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Gene Therapy Works for 'Bubble Boy' Disease

Gene Therapy Works for 'Bubble Boy' Disease | Aspect 2 & 3 | Scoop.it
Nine years after getting gene therapy for a rare, inherited immune system disorder often called (RT @Dnaliveforever: Gene therapy
works for
‘bubble boy’
disease
http://t.co/KKgFccQcB9...

Via joyrosario
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Katherine Shaw's comment, March 7, 2014 11:07 AM
10) A trial study was done on 16 patients who had SCID. This patients (all children 3 years and younger) were treated with gene therapy. The purpose of the therapy was to correct the gene to form the missing part of the gene that caused this auto immune deficiancy.
Katherine Shaw's comment, March 7, 2014 11:09 AM
11) This trial was done 10 years ago and out of the 16 patients, 14 of them are living healthy lives with perfectly working immune systems. Which is a much better percent than the other methods of treatment such as bone marrow.
Katherine Shaw's comment, March 7, 2014 11:11 AM
12) Although this trial was overwhelmingly successful, there were some complications. One of these complications was patients getting leukemia caused by the gene therapy. "Kohn says. "Ten years ago, these treatments started to work, but with complications. The hope is that the next decade will bring highly effective treatments with few complications.” - (CITE).
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Gene Therapy May Restore Sight in People With Rare Blinding ...

Gene Therapy May Restore Sight in People With Rare Blinding ... | Aspect 2 & 3 | Scoop.it
THURSDAY, Jan. 16, 2014 (HealthDay News) -- A new gene therapy that successfully treated a rare eye disease in clinical trials could prove the key to preventing more common inherited causes of blindness, researchers say.
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Katherine Shaw's comment, March 5, 2014 11:16 AM
2) In a trial, doctors treated six patients with a virus to repair the gene that choroidermeia causes damage to. The patients all showed signs of vision improvement which was extremely promising. These signs of improvement ranged from seeing more light to even being able to read more lines on the chart.
Katherine Shaw's comment, March 5, 2014 11:17 AM
3) With the promising results from this trial, the hope is that gene therapy can help prevent commonly inhereited eye diseases (maybe even before the blindness started occuring.)
Katherine Shaw's comment, March 5, 2014 11:18 AM
4) "lead author Robert MacLaren of the Nuffield Laboratory of Ophthalmology at the University of Oxford, and a consultant surgeon at the Oxford Eye Hospital, in England stated,"It's one disease, it's quite rare, but it represents a big step forward."