A well-known mechanism required for the immune response is now better understood, thanks to new research. Researchers have identified a protein that controls the activity of the p53 tumor suppressor protein known as the 'guardian of the genome.'
The current Ebola virus outbreak in West Africa, which has claimed more than 2000 lives, has highlighted the need for a deeper understanding of the molecular biology of the virus that could be critical in the development of vaccines or antiviral drugs to treat or prevent Ebola hemorrhagic fever.
Researchers have identified an RNA known as INXS that modulates the action of an important gene in the process of programmed cell death. In experiments on mice, they were able to effect a 10-fold reduction in the volume of subcutaneous malignant tumors.
Uncontrolled cell growth and division is a hallmark of cancer. Now a research project has provided the most complete description to date of the gene activity that takes place as human cells divide. Researchers have managed to gather data which details the behavior of protein molecules encoded by over 6000 genes in cancer cells, as they move through the cell cycle. The team has used advances in technology and data analysis to study how genes work over time in cancer cells, as opposed to capturing a `snapshot' of activity -- a leap forward they describe as akin to `jumping from still photography to video'.
Researchers report that disrupting the light-dark cycle of mice increased their susceptibility to inflammatory disease, indicating that the production of a key immune cell is controlled by the body’s circadian clock.
Definiens and Advanced Cell Diagnostics announced the commercial launch of RNAscope® SpotStudio™, a custom-designed image analysis software (Definiens and Advanced Cell Diagnostics Launch Software for Quantitative RNA In Situ Hybridization | Business...
Merlin and Hippo proteins interact to begin chain of events that control ... News-Medical.net Johns Hopkins researchers have figured out the specific job of a protein long implicated in tumors of the nervous system.
An international multi-laboratory team has demonstrated a new software tool, the 'erccdashboard,' that can evaluate the performance of experimental methods used to study gene expression. It provides the first standardized approach for any lab to evaluate the quality of its gene expression analyses.
The heart disease drug perhexiline is one of 101 compounds predicted to prevent cancer growth in most patients suffering from our most common liver cancer, HCC. This is an outcome from a novel simulation-based approach using personal sets of proteins of six HCC patients. "This is the first time personalized models have been used to find and evaluate new potential drugs," says an author.
Several key proteins of the heat shock response became centers of heat shock-induced local communities, as well as bridges providing a residual connection of modules after heat shock. The observed changes resemble to a ‘stratus-cumulus’ type transition of the interactome structure, since the unstressed yeast interactome had a globally connected organization, similar to that of stratus clouds, whereas the heat shocked interactome had a multifocal organization, similar to that of cumulus clouds. Our results showed that heat shock induces a partial disintegration of the global organization of the yeast interactome. This change may be rather general occurring in many types of stresses. Moreover, other complex systems, such as single proteins, social networks and ecosystems may also decrease their inter-modular links, thus develop more compact modules, and display a partial disintegration of their global structure in the initial phase of crisis. Thus, our work may provide a model of a general, system-level adaptation mechanism to environmental changes.
Scientists pinpoint proteins vital to long-term memory Medical Xpress The study, published online ahead of print on September 12, 2013 by the journal Cell Reports, focuses on a family of proteins called Wnts.
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