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RNAissance Therapeutics

RNAissance Therapeutics is a nanotherapeutics company based in Cambridge, UK. RNAissance is currently developing a novel treatment for Glioblastom
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The Cure for Cancer Is Data—Mountains of Data

The Cure for Cancer Is Data—Mountains of Data | Proteomics | Scoop.it
We must access genetic info from millions of cancer patients to make the connections necessary to battle the disease. It won't be easy, but we can do it.
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Computer model enables design of complex DNA shapes

Computer model enables design of complex DNA shapes | Proteomics | Scoop.it
Engineers computer-design the most complicated 3-D structures ever made from DNA.

Via Integrated DNA Technologies
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To Read Our DNA, We Need to Crack Another Genetic Code

To Read Our DNA, We Need to Crack Another Genetic Code | Proteomics | Scoop.it
The only problem is that it may not be much of a code at all.

Via Integrated DNA Technologies
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Protein that controls the 'guardian of the genome' identified

Protein that controls the 'guardian of the genome' identified | Proteomics | Scoop.it
A well-known mechanism required for the immune response is now better understood, thanks to new research. Researchers have identified a protein that controls the activity of the p53 tumor suppressor protein known as the 'guardian of the genome.'
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P53

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Protein secrets of Ebola virus

Protein secrets of Ebola virus | Proteomics | Scoop.it
The current Ebola virus outbreak in West Africa, which has claimed more than 2000 lives, has highlighted the need for a deeper understanding of the molecular biology of the virus that could be critical in the development of vaccines or antiviral drugs to treat or prevent Ebola hemorrhagic fever.
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The key to combating Ebola...

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RNA that regulates cell death identified

Researchers have identified an RNA known as INXS that modulates the action of an important gene in the process of programmed cell death. In experiments on mice, they were able to effect a 10-fold reduction in the volume of subcutaneous malignant tumors.
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'Most complete' picture of gene expression in cancer cell cycle caught

'Most complete' picture of gene expression in cancer cell cycle caught | Proteomics | Scoop.it
Uncontrolled cell growth and division is a hallmark of cancer. Now a research project has provided the most complete description to date of the gene activity that takes place as human cells divide. Researchers have managed to gather data which details the behavior of protein molecules encoded by over 6000 genes in cancer cells, as they move through the cell cycle. The team has used advances in technology and data analysis to study how genes work over time in cancer cells, as opposed to capturing a `snapshot' of activity -- a leap forward they describe as akin to `jumping from still photography to video'.
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How body clock affects inflammation: Discovery could accelerate body's response to infection, autoimmune disorders

How body clock affects inflammation: Discovery could accelerate body's response to infection, autoimmune disorders | Proteomics | Scoop.it
Researchers report that disrupting the light-dark cycle of mice increased their susceptibility to inflammatory disease, indicating that the production of a key immune cell is controlled by the body’s circadian clock.
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Scientists reveal how beta-amyloid may cause Alzheimer's

Scientists reveal how beta-amyloid may cause Alzheimer's | Proteomics | Scoop.it
Scientists have shown how a protein fragment known as beta-amyloid, strongly implicated in Alzheimer's disease, begins destroying synapses before it clumps into plaques that lead to nerve cell death.
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Definiens and Advanced Cell Diagnostics Launch Software for Quantitative RNA In Situ Hybridization | Business Wire

Definiens and Advanced Cell Diagnostics Launch Software for Quantitative RNA In Situ Hybridization | Business Wire | Proteomics | Scoop.it
Definiens and Advanced Cell Diagnostics announced the commercial launch of RNAscope® SpotStudio™, a custom-designed image analysis software (Definiens and Advanced Cell Diagnostics Launch Software for Quantitative RNA In Situ Hybridization | Business...
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Merlin and Hippo proteins interact to begin chain of events that control ... - News-Medical.net

Merlin and Hippo proteins interact to begin chain of events that control ... - News-Medical.net | Proteomics | Scoop.it
Merlin and Hippo proteins interact to begin chain of events that control ...
News-Medical.net
Johns Hopkins researchers have figured out the specific job of a protein long implicated in tumors of the nervous system.
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Perspectives on RNA Sequencing: Deeper Insights

Matt Thomas, a research associate studying host-viral pathogen responses through RNA-seq is fascinated by the high-throughput and simplified workflow o
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Research | Research news | 2014 | Duality in the human genome

Research | Research news | 2014 | Duality in the human genome | Proteomics | Scoop.it
Human genomes are extraordinarily individual - a challenge for personalised medicine.

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ChIP-RNA-seq | RNA-Seq Blog

ChIP-RNA-seq | RNA-Seq Blog | Proteomics | Scoop.it
Intro Biostatistics and Bioinformatics, lec 23 ChIP-seq and RNA-seq presented by Stuart Brown

Via Mel Melendrez-Vallard
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Reliable RNA analysis now easier with 'dashboard' tool

Reliable RNA analysis now easier with 'dashboard' tool | Proteomics | Scoop.it
An international multi-laboratory team has demonstrated a new software tool, the 'erccdashboard,' that can evaluate the performance of experimental methods used to study gene expression. It provides the first standardized approach for any lab to evaluate the quality of its gene expression analyses.
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Zaire ebolavirus isolate Ebola virus H.sapiens-tc/COD/1976/Yambuku-May - Nucleotide - NCBI

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Biochemical and Functional Characterization of the Ebola Virus VP24 Protein: Implications for a Role in Virus Assembly and Budding

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Network Biology

Network Biology | Proteomics | Scoop.it
Network Biology

Via Dmitry Alexeev
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Systems Biology?

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Dmitry Alexeev's curator insight, April 14, 2014 1:10 AM

the page camoe useful for me with marveloous collection of works and refernces

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101 liver cancer drug candidates pave way to personalized medicine

101 liver cancer drug candidates pave way to personalized medicine | Proteomics | Scoop.it
The heart disease drug perhexiline is one of 101 compounds predicted to prevent cancer growth in most patients suffering from our most common liver cancer, HCC. This is an outcome from a novel simulation-based approach using personal sets of proteins of six HCC patients. "This is the first time personalized models have been used to find and evaluate new potential drugs," says an author.
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Edited RNA plus invasive DNA add individuality

Edited RNA plus invasive DNA add individuality | Proteomics | Scoop.it
An enzyme that edits RNA may loosen the genome's control over invasive snippets of DNA that affect how genes are expressed, according to new research.
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PLOS Computational Biology: Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation

PLOS Computational Biology: Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation | Proteomics | Scoop.it

Several key proteins of the heat shock response became centers of heat shock-induced local communities, as well as bridges providing a residual connection of modules after heat shock. The observed changes resemble to a ‘stratus-cumulus’ type transition of the interactome structure, since the unstressed yeast interactome had a globally connected organization, similar to that of stratus clouds, whereas the heat shocked interactome had a multifocal organization, similar to that of cumulus clouds. Our results showed that heat shock induces a partial disintegration of the global organization of the yeast interactome. This change may be rather general occurring in many types of stresses. Moreover, other complex systems, such as single proteins, social networks and ecosystems may also decrease their inter-modular links, thus develop more compact modules, and display a partial disintegration of their global structure in the initial phase of crisis. Thus, our work may provide a model of a general, system-level adaptation mechanism to environmental changes.

  


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Dmitry Alexeev's curator insight, August 20, 2013 5:27 AM

networks... heatshock,,, yummy)

 

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Scientists pinpoint proteins vital to long-term memory - Medical Xpress

Scientists pinpoint proteins vital to long-term memory - Medical Xpress | Proteomics | Scoop.it
Scientists pinpoint proteins vital to long-term memory
Medical Xpress
The study, published online ahead of print on September 12, 2013 by the journal Cell Reports, focuses on a family of proteins called Wnts.
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