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Rescooped by David Sawyer from Breast Cancer News
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$5.9 million grant adds androgen receptor as a new driver and target in breast cancer

$5.9 million grant adds androgen receptor as a new driver and target in breast cancer | Prostate Cancer | Scoop.it

"A major Department of Defense grant to researchers Jennifer Richer, PhD, and Anthony Elias, MD, at the University of Colorado Cancer Center aids development of drugs that target androgen receptors as a driver of breast cancer.

In August 2013, patient Linda Griffin failed her second aromatase inhibitor. Three and a half years ago, she had been diagnosed with estrogen-positive (ER+) metastatic breast cancer and with August's news she was running out of hormonal therapies.

"My oncologist had been a resident at the University of Colorado and so when my treatment failed, he said it was time to call Dr. Elias," Griffin says.

Anthony Elias, MD, is breast cancer program director at CU Cancer Center and the clinician side of a clinician-researcher team with Jennifer Richer, PhD, associate professor of pathology and co-director of the CU Cancer Center Tissue Processing and Procurement Core. Together, Richer and Elias have spent a decade laying the groundwork for targeting androgen receptors in breast cancer. Now the team expects this major Department of Defense grant will allow them to place androgen receptors alongside those for estrogen and progesterone as hormonal drivers of breast cancer, and a target for drugs that treat the disease.

"Breast cancers have addictions," says Elias. "Some are addicted to estrogen, some to progesterone, some depend on the growth factor HER2. You use drugs to take away these things the cancer needs and the cancer can't grow."


Via Susan Zager
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Susan Zager's curator insight, October 3, 2013 12:44 PM

Blocking androgen receptors is not new. Even though this is not beginning trials till 2014, the concept of finding chemotherapy agents that can target androgen receptors for triple negative breast cancer and/or ER+ that had turned negative holds promise for the future. 

Heather Swift's curator insight, October 9, 2013 8:42 PM

Blocking androgen receptors is not new. Even though this is not beginning trials till 2014, the concept of finding chemotherapy agents that can target androgen receptors for triple negative breast cancer and/or ER+ that had turned negative holds promise for the future.

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Survival for advanced prostate cancer 'triples' for men on trials : Cancer Research UK

Survival for advanced prostate cancer 'triples' for men on trials : Cancer Research UK | Prostate Cancer | Scoop.it
Men with advanced, incurable prostate cancer who are treated with the latest drugs have nearly three times the life expectancy of men treated a decade ago, according to data from the Royal Marsden Hospital.
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Bizarre study shows that advertising improves effectiveness of drugs - io9

Bizarre study shows that advertising improves effectiveness of drugs - io9 | Prostate Cancer | Scoop.it
Bizarre study shows that advertising improves effectiveness of drugs
io9
You've probably heard of the placebo effect, where people's ailments improve when they believe they've been given medicine — even if that medicine is just a sugar pill.
David Sawyer's insight:

The power of medical communications

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