Pourquoi's innova...
Follow
Find
443 views | +0 today
Rescooped by Josie Gibson from Designing design thinking driven operations
onto Pourquoi's innovation and creativity digest
Scoop.it!

6 Mega Trends for 2014

6 Mega Trends for 2014 | Pourquoi's innovation and creativity digest | Scoop.it
Predicting the future is a fraught business yet this year seems to hold important clues for 2014. Here is my personal list.

Via Fred Zimny
Josie Gibson's insight:

'Buzzword-free'...

more...
Linda Alexander's curator insight, December 17, 2013 4:58 AM

The beginning of all the year-end top 10 lists....(oh, but this list only contains the top 6...with a tech-laden focus)

Pourquoi's innovation and creativity digest
Latest thinking on innovation and creativity
Curated by Josie Gibson
Your new post is loading...
Rescooped by Josie Gibson from Amazing Science
Scoop.it!

Size of the human genome reduced to 19,000 genes

Size of the human genome reduced to 19,000 genes | Pourquoi's innovation and creativity digest | Scoop.it

A study led by Alfonso Valencia, Vice-Director of Basic Research at the Spanish National Cancer Research Centre (CNIO) and head of the Structural Computational Biology Group, and Michael Tress, researcher at the Group, updates the number of human genes -those that can generate proteins- to 19,000; 1,700 fewer than the genes in the most recent annotation, and well below the initial estimations of 100,000 genes. The work, published in the journal Human Molecular Genetics, concludes that almost all of these genes have ancestors prior to the appearance of primates 50 million years ago.

 

"The shrinking human genome," that's how Valencia describes the continuous corrections to the numbers of the protein-coding genes in the human genome over the years that has culminated in the approximately 19,000 human genes described in the present work. "The coding part of the genome [which produces proteins] is constantly moving," he adds: "No one could have imagined a few years ago that such a small number of genes could make something so complex."

 

The scientists began by analysing proteomics experiments; proteomics is the most powerful tool to detect protein molecules. In order to determine a map of human proteins the researchers integrated data from seven large-scale mass spectrometry studies, from more than 50 human tissues, "in order to verify which genes really do produce proteins " says Valencia.

 

The results brought to light just over 12,000 proteins and the researchers mapped these proteins to the corresponding regions of the genome. They analysed thousands of genes that were annotated in the human genome, but that did not appear in the proteomics analysis and concluded: "1,700 of the genes that are supposed to produce proteins almost certainly do not for various reasons, either because they do not exhibit any protein coding features, or because the conservation of their reading frames does not support protein coding ability, "says Tress.

 

One hypothesis derived from the study is that more than 90% of human genes produce proteins that originated in metazoans or multicellular organisms of the animal kingdom hundreds of millions of years ago; the figure is over 99% for those genes whose origin predates the emergence of primates 50 million years ago.

 

"Our figures indicate that the differences between humans and primates at the level of genes and proteins are very small," say the researchers. David Juan, author and researcher in the Valencia lab, says that "the number of new genes that separate humans from mice [those genes that have evolved since the split from primates] may even be fewer than ten." This contrasts with the more than 500 human genes with origins since primates that can be found in the current annotation. The researchers conclude: "The physiological and developmental differences between primates are likely to be caused by gene regulation rather than by differences in the basic functions of the proteins in question."

 

The sources of human complexity lie more in how genes are used rather than on the number of genes, in the thousands of chemical changes that occur in proteins or in the control of the production of these proteins by non-coding regions of the genome, which comprise 90% of the entire genome and which have been described in the latest findings of the international ENCODE project, a Project in which the Valencia team participates.

 

The work brings the number of human genes closer to other species such as the nematode worms Caenorhabditis elegans, worms that are just 1mm long, but apparently less complex than humans. But Valencia prefers not to make comparisons: "The human genome is the best annotated, but we still believe that 1,700 genes may have to be re-annotated. Our work suggests that we will have to redo the calculations for all genomes, not only the human genome."

 

The research results are part of GENCODE, a consortium which is integrated into the ENCODE Project and formed by research groups from around the world, including the Valencia team, whose task is to provide an annotation of all the gene-based elements in the human genome.

 

"Our data are being discussed by GENCODE for incorporation into the new annotations. When this happens it will redefine the entire mapping of the human genome, and how it is used in macro projects such as those for cancer genome analysis ," says Valencia.


Via Dr. Stefan Gruenwald
more...
Laura E. Mirian, PhD's curator insight, July 8, 7:42 AM

"Our figures indicate that the differences between humans and primates at the level of genes and proteins are very small," say the researchers. 

Scooped by Josie Gibson
Scoop.it!

Julian Birkinshaw: Schumpeter: The holes in holacracy | The Economist

Julian Birkinshaw: Schumpeter: The holes in holacracy | The Economist | Pourquoi's innovation and creativity digest | Scoop.it
“Nine-tenths of the approximately 100 branded management ideas I’ve studied lost their popularity within a decade or so,” wrote Julian Birkinshaw of London Business School in the May issue of the Harvard Business Review. Among the latest cast-offs, it seems, is Google’s much-admired “20% ...
more...
No comment yet.
Rescooped by Josie Gibson from Knowledge Broker
Scoop.it!

The Secret To Creativity, Intelligence, And Scientific Thinking

The Secret To Creativity, Intelligence, And Scientific Thinking | Pourquoi's innovation and creativity digest | Scoop.it

Research shows that creativity and intelligence are linked with the physical connections in our brains. Here's how to connect the dots.


Via Kenneth Mikkelsen
more...
No comment yet.
Rescooped by Josie Gibson from Knowledge Broker
Scoop.it!

Secrets of the Creative Brain

Secrets of the Creative Brain | Pourquoi's innovation and creativity digest | Scoop.it

A leading neuroscientist who has spent decades studying creativity shares her research on where genius comes from, whether it is dependent on high IQ - and why it is so often accompanied by mental illness. 


Via Kenneth Mikkelsen
more...
David Hain's curator insight, June 28, 11:15 PM

'Some people see things others cannot, and they are right, and we call them creative geniuses. Some people see things others cannot, and they are wrong, and we call them mentally ill. And some people, like John Nash, are both.'

Scooped by Josie Gibson
Scoop.it!

Learning Collaboration from Tiki-Taka Soccer

Learning Collaboration from Tiki-Taka Soccer | Pourquoi's innovation and creativity digest | Scoop.it

Our work with several European corporations show that most companies fall short of understanding the dynamic, multifaceted, and interlinked demands they face.  Instead of adapting rapidly to the fast-changing and complicated world, they press on with more of the same...

Josie Gibson's insight:

Ashby's law: Complexity can only be countered by complexity.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Capitalism Redefined

Capitalism Redefined | Pourquoi's innovation and creativity digest | Scoop.it
For everyone but the top 1 percent of earners, the American economy is broken. Since the 1980s, there has been a widening disconnect between the lives lived by ordinary Americans and the statistics that say our prosperity is growing. Despite
Josie Gibson's insight:

Incisive questions about how we view and measure economic 'progress' and 'growth'.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

The Only Viable Strategy Is Adaptation

The Only Viable Strategy Is Adaptation | Pourquoi's innovation and creativity digest | Scoop.it

Most managers take it for granted that the world has become much more volatile and complex and that we need to constantly adapt.  The days when we could simply plan and execute are long gone.

So it was notable, to say the least, when Roger Martin recently wrote in Harvard Business Review that he thinks that all the talk about adaptive strategy is a cop-out.  In his mind, it is just a way for managers to get out of making hard, dangerous choices.

 

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Jill Lepore: What the Theory of “Disruptive Innovation” Gets Wrong

Jill Lepore: What the Theory of “Disruptive Innovation” Gets Wrong | Pourquoi's innovation and creativity digest | Scoop.it
Clayton Christensen’s theory of “disruptive innovation” is founded on anxiety, fear, and shaky evidence.
Josie Gibson's insight:

Thoughtful and elegantly written exploration of our current preoccupation with all things innovative...

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

How To Measure Innovation (To Get Real Results)

How To Measure Innovation (To Get Real Results) | Pourquoi's innovation and creativity digest | Scoop.it
Metrics are a combination of art and science. The trick is to inspire action around the goals you set.
more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Seth's Blog: In search of meaningful

Seth's Blog: In search of meaningful | Pourquoi's innovation and creativity digest | Scoop.it
From the individual who needs to get her idea in front of the right people, to the New York Times, which faces a ticking clock to figure out the digital landscape, all of us are in the media business. There's...
Josie Gibson's insight:

Insightful piece on where the media industry is failing to capitalise on the opportunities of disruption.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

The Revolution of the Data Slaves

The Revolution of the Data Slaves | Pourquoi's innovation and creativity digest | Scoop.it
Some years ago, when Facebook “only” had 356M users, I remember Marc Zuckerberg saying: “… changing the privacy options of 356M users overnight, that’s not something everybody would do. Well, we de...
Josie Gibson's insight:

Thought-provoking post by Peter Van on identity and the digital age.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Summer Reading List: Books That Explain The Future

Summer Reading List: Books That Explain The Future | Pourquoi's innovation and creativity digest | Scoop.it

Great list curatedIf you want to know what to expect in the years to come, these books not only offer important insights, they are great reads too!

Josie Gibson's insight:

Wonderful list curated by Greg Satell - @Digitaltonto

more...
No comment yet.
Rescooped by Josie Gibson from visual data
Scoop.it!

40 Maps That Explain The Internet

40 Maps That Explain The Internet | Pourquoi's innovation and creativity digest | Scoop.it

The internet increasingly pervades our lives, delivering information to us no matter where we are. It takes a complex system of cables, servers, towers, and other infrastructure, developed over decades, to allow us to stay in touch with our friends and family so effortlessly. Here are 40 maps that will help you better understand the internet — where it came from, how it works, and how it's used by people around the world.


Via Lauren Moss
more...
ReCom's curator insight, June 18, 1:13 AM

Quelques explications concernant Internet pour comprendre comment nous en sommes arrivés jusque là.

Iron Dane Richards's curator insight, June 20, 7:19 AM

Great Article once again by Lauren Moss on 40 Maps that Explain Internet Traffic Systems in the USA

Shyamal Bose's curator insight, June 21, 11:53 PM

please visit my blog and get all traveling spots in the world.It is one of the Tourist guide which is help all of the visitor. So, Please visit :

http://bestplacetourism.blogspot.in/

 

Scooped by Josie Gibson
Scoop.it!

Cut through questions to survive digital disruption - Australian Institute of Company Directors

Cut through questions to survive digital disruption - Australian Institute of Company Directors | Pourquoi's innovation and creativity digest | Scoop.it
A new report singles out six industries, representing one third of the $1.4 trillion Australian economy, that will be subject to the next big wave of disruption. It also suggests some questions boards should ask to avoid management complacency.
Josie Gibson's insight:

A good set of questions for any organisation.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Boards Still Don't See the Value of Digital

Boards Still Don't See the Value of Digital | Pourquoi's innovation and creativity digest | Scoop.it

Companies across the world are ramping up their digital initiatives, according to a new survey from McKinsey, with the C-suite increasingly leading the way. “Digitization has become a critical asset in many companies’ quest for growth,” write the report’s authors, noting the increased involvement by CEOs and other top executives.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

The Paying-It-Forward Payoff

The Paying-It-Forward Payoff | Pourquoi's innovation and creativity digest | Scoop.it

Most of us are familiar with direct reciprocity – the idea that people respond to kind actions directed toward them with other kind actions. But generalized reciprocity — “you help me and I help someone else” can be a bit trickier to measure. New research, however, shows that it might be possible for companies to encourage such generosity among employees.

Josie Gibson's insight:

Nice post by @gretchenmarg on how to encourage collaboration.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

If the Internet is a Psychology Experiment, Are You a Psychologist?

If the Internet is a Psychology Experiment, Are You a Psychologist? | Pourquoi's innovation and creativity digest | Scoop.it
We've reached a point where startups can base their business model on the rapid testing of multiple prototypes. Scott Adams of Dilbert fame argues that this basically makes starting up a big psychology experiment. If we are in established firms, we need to build some skills to compete in this environment.
Josie Gibson's insight:

Great post by @timkastelle. "We all need to be more skeptical of our ideas.  Instead of banking on getting everything right from the start, we need to be more suspicious of our initial assumptions." 

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

The Renaissance We Need in Business Education

The Renaissance We Need in Business Education | Pourquoi's innovation and creativity digest | Scoop.it

Business education today is anachronistic in both how it is conducted and what its content focuses on. Our brick institutions have in no way caught up with what today’s technologies make possible in terms of virtual learning and individualized, customized instruction.

Josie Gibson's insight:

At last - someone questions why we keep training leaders for a world that not longer exists...

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Are global companies wringing all of the innovation out of their businesses in pursuit of profits?

Are global companies wringing all of the innovation out of their businesses in pursuit of profits? | Pourquoi's innovation and creativity digest | Scoop.it
Clayton Christensen is popular among the tech-set, with his economic theories being one explanation for the way startups can disrupt established industries. But Christensen, in a new op-ed, argues that modern corporate governance is completely driving innovation out of business.
Josie Gibson's insight:

Via @kristofdewulf

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Clayton Christensen Responds to New Yorker Takedown of 'Disruptive Innovation'

Clayton Christensen Responds to New Yorker Takedown of 'Disruptive Innovation' | Pourquoi's innovation and creativity digest | Scoop.it
Harvard business guru accuses Harvard history professor of "criminal act of dishonesty"
Josie Gibson's insight:

The father of disruptive innovation fights back.

more...
Jason Leong's curator insight, June 25, 2:47 PM

The more people talk about "disruption" the more it just seems like capitalism at work. You make a half decent product for cheap, or you make a product that no one else is making and if you've picked it right, you eat someone else's lunch.

Scooped by Josie Gibson
Scoop.it!

The World in 2030: Four scenarios for long-term planning and strategy

The World in 2030: Four scenarios for long-term planning and strategy | Pourquoi's innovation and creativity digest | Scoop.it
A brief overview of the scenarios for the world to 2030 by Australian futurist and keynote speaker Ross Dawson.
more...
No comment yet.
Rescooped by Josie Gibson from Designing design thinking driven operations
Scoop.it!

Is Disruption Dead? - Forbes

Is Disruption Dead? - Forbes | Pourquoi's innovation and creativity digest | Scoop.it

Is Disruption Dead? Forbes In 1997, a little known Harvard professor named Clayton Christensen published a surprise bestseller called The Innovators's Dilemma, where he coined the term disruptive technology, which later evolved into disruptive...


Via Fred Zimny
Josie Gibson's insight:

And the debate rages...

more...
Scooped by Josie Gibson
Scoop.it!

Beyond Network Feudalism

Beyond Network Feudalism | Pourquoi's innovation and creativity digest | Scoop.it
The Internet that appears distributed is fundamentally centralized. Right now there are key players that sit atop the largest networks reaping all the financial rewards....
more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

Julian Birkinshaw: One management fad does not fit all - The Globe and Mail

Julian Birkinshaw: One management fad does not fit all - The Globe and Mail | Pourquoi's innovation and creativity digest | Scoop.it
ASSOCIATED PRESS Julian Birkinshaw, a professor at London Business School who earned his doctorate at the University of Western Ontario’s Richard Ivey School of Business, has studied the spread of management ideas and has a simple warning: Buyer beware. “A lot of these ideas tend to fail ...
Josie Gibson's insight:

Extract principles rather than adopting someone else's ideas/frameworks - then you might get an appropriate cultural fit.

more...
No comment yet.
Scooped by Josie Gibson
Scoop.it!

No Innovation Is Immediately Profitable

No Innovation Is Immediately Profitable | Pourquoi's innovation and creativity digest | Scoop.it

As much as we like to believe in overnight success stories, most start-up businesses fail, and those that don’t typically go through a fair number of twists and turns before they find their way to success.

Josie Gibson's insight:

If you're not prepared to fund disruptive ideas for the medium to long-term, don't play in that space. Save yourself and your team the frustration.

more...
No comment yet.