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© 2012 American Society of Plant Biologists. All rights reserved.
Conserved Noncoding Sequences Highlight Shared Components of Regulatory Networks in Dicotyledonous Plants[W]
Laura Baxtera,1,Aleksey Jironkina,1,Richard Hickmana,1,Jay Moorea,Christopher Barringtona,Peter Kruschea,Nigel P. Dyerb,Vicky Buchanan-Wollastona,c,Alexander Tiskind,Jim Beynona,c,Katherine Denbya,c andSascha Otta,2
+ Author Affiliations
aWarwick Systems Biology Centre, University of Warwick, Coventry CV4 7AL, United Kingdom
bMolecular Organisation and Assembly in Cells Doctoral Training Centre, University of Warwick, Coventry CV4 7AL, United Kingdom
cSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
dDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, United Kingdom
↵2Address correspondence to email@example.com
Published online before print October 2012, doi: http://dx.doi.org/10.1105/tpc.112.103010 The Plant Cell October 2012 vol. 24 no. 10 3949-3965
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Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar [Populus trichocarpa], and grape [Vitis vinifera]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research.