Physiologically Relevant Cell Culture
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The boom in mini stomachs, brains, breasts, kidneys and more

The boom in mini stomachs, brains, breasts, kidneys and more | Physiologically Relevant Cell Culture | Scoop.it
Biologists are building banks of 'organoids', and learning a lot about human development on the way.
Physiologically Relevant Cell Culture's insight:

A great summary on current developments in organoid culture.

In addition to this insight,  recent research by Huch and Clevers has succeeded in long-term liver organoid culture. More information on this can be found:  http://www.amsbio.com/Long-term-organoid-culture-on-BME2-RGF.aspx

 

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A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression

A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression | Physiologically Relevant Cell Culture | Scoop.it
Physiologically Relevant Cell Culture's insight:

Novel research has investigated the effect of dimethyloxalylglycine (DMOG) on cell metabolism. MitoXpress® Xtra probes, as available from AMSBIO, allowed the real-time analysis of cellular respiration and mitochondrial function. This analysis was performed on a 3D spheroid culture, produced from reagents also provided by AMSBIO to show impaired deep cell deoxygenation in tumours, ischaemic, and inflamed tissues. MitoXpress®-Xtra products: https://lnkd.in/djWfMcc Spheroid Formation ECM and Low-Adhesion Plate: https://lnkd.in/dKd2KJd

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Guide to organoid growth - News-Medical.net

Guide to organoid growth - News-Medical.net | Physiologically Relevant Cell Culture | Scoop.it
AMSBIO has launched, at the ‘Frontiers in Stem Cells & Cancer' EMBL-EMBO Symposium**, a guide that illustrates a variety of organoids grown from different tissues by leading international research groups using BME 2 reduced growth factor...
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3D cell culture: an interview with Dr. Elad Katz, Senior Scientist, AMSBIO

3D cell culture: an interview with Dr. Elad Katz, Senior Scientist, AMSBIO | Physiologically Relevant Cell Culture | Scoop.it
For over fifty years now, we have used 2D cell cultures to culture a variety of cells such as epithelial and blood cells and these are excellent for maintaining cells in their inherent state, under controlled, temperature and other conditions. However, they are limited in preserving the genotype and the phenotype of the original tissue these cells came from.
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AMSBIO to Launch 384-Well 3D Cell Culture Plates at SLAS 2014

AMSBIO to Launch 384-Well 3D Cell Culture Plates at SLAS 2014 | Physiologically Relevant Cell Culture | Scoop.it

AMSBIO, specialists in 3D cell culture technology, has announced the launch of a 384-well version of the popular Alvetex®Scaffold cell culture plates. The new Alvetex®Scaffold 3D cell culture plates provide biopharmaceutical companies with a new tool to improve the predictive accuracy, productivity and biological relevance of their cell based high throughput testing

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Reinnervate, Roslin Cellab partner to develop 3D stem cell printing products ... - News-Medical.net

Reinnervate, Roslin Cellab partner to develop 3D stem cell printing products ... - News-Medical.net | Physiologically Relevant Cell Culture | Scoop.it
Reinnervate, Roslin Cellab partner to develop 3D stem cell printing products ...
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Danish Researchers Create 3D Culture Method And Grow Miniature Pancreas - Forbes

Danish Researchers Create 3D Culture Method And Grow Miniature Pancreas - Forbes | Physiologically Relevant Cell Culture | Scoop.it
Danish Researchers Create 3D Culture Method And Grow Miniature Pancreas Forbes Researchers at the University of Copenhagen at the Danish Stem Cell Centre say they have developed a new 3D culture method and grew a miniature pancreas from progenitor...
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Cell and Tissue Culture - nature.com marketplace

Cell and Tissue Culture - nature.com marketplace | Physiologically Relevant Cell Culture | Scoop.it
Culturing and maintaining cells is like taking care of small children: caretakers feed them, change them, and watch them grow.
Physiologically Relevant Cell Culture's insight:
Do Right By Your Cells - An Overview of Recently Released Cell and Tissue Culture Technologies
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An introduction to Alvetex® technology- what is it made of ? What are the advantages over traditional plastic ware...

An introduction to Alvetex® technology- what is it made of ? What are the advantages over traditional plastic ware... | Physiologically Relevant Cell Culture | Scoop.it
Alvetex® is a synthetic scaffold that is used to form the micro-architecture over which 3D cell culture is performed.
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WHAT is 3D culture and WHY use it?

WHAT is 3D culture and WHY use it? | Physiologically Relevant Cell Culture | Scoop.it
Physiologically Relevant Productive Cell Culture

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AMSBIO's curator insight, June 24, 2013 3:40 AM

An informative interactive guide (also available in downloadable pdf version) 

which looks at different 3D cell culture technologies and it's application. Read the guide to learn which 3D cell culture format is best for you, which matrix or scaffold is most applicable to your needs and how to integrate your read-outs when implementing 3D cell culture.

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AMSBIO Launches New Basement Membrane Extracts - MeasurementDevices

AMSBIO Launches New Basement Membrane Extracts - MeasurementDevices | Physiologically Relevant Cell Culture | Scoop.it
AMSBIO Launches New Basement Membrane Extracts MeasurementDevices Abingdon, UK & Lake Forest CA, USA -- AMSBIO announces the availability of two new formulations of Basement Membrane Extract (BME) known as Cultrex BME 2 (organoid growth matrix) and...
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Optimized Basement Membrane Extracts for Organoid Growth and Xenograft ... - Bioscience Technology

Optimized Basement Membrane Extracts for Organoid Growth and Xenograft ... - Bioscience Technology | Physiologically Relevant Cell Culture | Scoop.it
Bioscience Technology
Optimized Basement Membrane Extracts for Organoid Growth and Xenograft ...
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3D Cell Culture of Osteocytes on the International Space Station using Reinnervate’s Alvetex®Scaffold SystemReinnervate

3D Cell Culture of Osteocytes on the International Space Station using Reinnervate’s Alvetex®Scaffold SystemReinnervate | Physiologically Relevant Cell Culture | Scoop.it
3D Cell Culture of Osteocytes on the International Space Station using Reinnervate’s Alvetex®Scaffold System read Reinnervate news in the SelectScience scientific news archive (3D Cell Culture of Osteocytes on the International Space Station using...
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TGFβ functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation

TGFβ functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation | Physiologically Relevant Cell Culture | Scoop.it
Physiologically Relevant Cell Culture's insight:

A new research in the field of skin tissue engineering has been published. The biocompatibility and activity of various custom star-PEG heparin hydrogels was tested. A. Watarai and her group were able to optimise the adhesion and proliferation of these cells. In addition to this, slight adjustment of hydrogen-delivered growth factors resulted in differentiation of fibroblasts into myofibroblasts. The matrix proteins were visualised with Sirius Red/Fast Green Collagen Staining Kit provided by AMSBIO:https://lnkd.in/djxt8rt

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Cultrex® BME used in co-culture of LAM cells and fibroblasts

Cultrex® BME used in co-culture of LAM cells and fibroblasts | Physiologically Relevant Cell Culture | Scoop.it
Recently a study investigating the pathology of lymphangioleiomyomatosis (LAM) and the relation to wild type mesenchymal cells was published. Lymphangioleiomyomatosis is a rare disease leading to unknown accumulation in the lungs and cysts formation. Among other analysing techniques fibroblast interaction with LAM cells was examined using basement membrane extract (BME provided by AMSBIO) as a 3D cell culture mimicking the in-vivo conditions. The behaviour of cells in the matrix was observed for 7 days and visualised with spinning disk confocal microscope.It was shown that LAM cells and fibro
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3D Triculture Model

3D Triculture Model | Physiologically Relevant Cell Culture | Scoop.it
Tri-culture
Physiologically Relevant Cell Culture's insight:

3D Triculture Model for Evaluating Breast Cancer Progression (developed from technology used in our spheroid assays) is part of a project to demonstrate feasibility for an advanced drug screening platform. The model shows that incorporating vascular and stromal cells with breast cancer tumor spheroids allows them to more closely mimic the extracellular environment, cellular architecture and behaviour of actual tumors; this triculture promotes growth, invasion and endothelial recruitment. More information:  http://www.amsbio.com/Tri-culture.aspx

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On-Demand Webinar from AMSBIO Addresses 3D Cell-Based Models for Regenerative Medicine

On-Demand Webinar from AMSBIO Addresses 3D Cell-Based Models for Regenerative Medicine | Physiologically Relevant Cell Culture | Scoop.it

On-Demand Webinar from AMSBIO Addresses 3D Cell-Based Models for Regenerative Medicine...

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A gutsy approach to stem cells and signalling: an interview with Hans Clevers

A gutsy approach to stem cells and signalling: an interview with Hans Clevers | Physiologically Relevant Cell Culture | Scoop.it

My last post looked at gut organoids - an exciting new way to study the human intestine in culture.  Gut organoids were developed by Hans Clevers and his team at the Hubrecht Institute for Stem Cell Research.  Now a Professor of Molecular Genetics at Utrecht University, Clevers is a pioneer of 3D cell culture who is continuing to explore the wonderful world of stem cells within the gut.

 

The link in the title above is to a recent interview in which Hans Clevers talks about his research and the things he has learned about lab management and mentorship.


Via Amanda Capes-Davis
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Yahoo News UK & Ireland - Latest World News & UK News Headlines

Yahoo News UK & Ireland - Latest World News & UK News Headlines | Physiologically Relevant Cell Culture | Scoop.it
3D microtumours developed so that new drugs against cancer can be tested on patients’ cells rather than animals: http://t.co/fH9EBysuB9
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The role of engineering approaches in analysing cancer invasion and metastasis : Nature Reviews Cancer : Nature Publishing Group

The role of engineering approaches in analysing cancer invasion and metastasis : Nature Reviews Cancer : Nature Publishing Group | Physiologically Relevant Cell Culture | Scoop.it
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Tailor made 3D Cell Culture ...color coded 3D cell culture solutions to suit individual protocols

Tailor made 3D Cell Culture ...color coded 3D cell culture solutions to suit individual protocols | Physiologically Relevant Cell Culture | Scoop.it
Traditional studies on cell and tissue regulation have relied on analysis of cells grown in 2D cell-culture. These 2D models have failed to reconstitute the in vivo cellular microenvironment and thus fail to maintain their differentiated functions.
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Webinar by Dr. Erik Miljan 3D Cell Culture in Drug Discovery and Disease Modeling PART I

3D Cell Culture in Drug Discovery presented by Dr. Erik Miljan

 

About Dr. Erik Miljan- 

Dr Erik Miljan has over 10 years' experience in the stem cell biotech sector, from intellectual property (IP) portfolio management through product development to regulatory approval.

He initiated, implemented and delivered the operational and management strategy leading to the first ever stem cell-based product approved for clinical trial in the UK, in addition to delivering non-therapeutic stem cell products to market.

He has experience in international settings across both academia and industry in the US, Japan, Australia and the European Union


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AMSBIO's curator insight, June 24, 2013 4:13 AM

Dr.Erik Miljan talks the most important advances in the 3D technology and its contribution to conducting more realistic research. 

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What are the new opportunities in cancer research ?

What are the new opportunities in cancer research ? | Physiologically Relevant Cell Culture | Scoop.it

 White paper: Incorporating the Extracellular Matrix: New Opportunities in Cancer Research


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AMSBIO's curator insight, June 24, 2013 4:36 AM

Learn about the ECM proteins most relevant to cancer research. Self-organization models are described, with particular focus on the use of reconstituted basement membrane to study epithelial behavior. The broader application of ECM substrates is also explored in studying motility, in the context of adhesion, migration and invasion assays. Additional use of ECM products in vivo is discussed as a method to enhance the use of animal models.

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Closer-to-Real 3D Cell Culture Advances - Genetic Engineering News

Closer-to-Real 3D Cell Culture Advances
Genetic Engineering News
... compounds.
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Amsbio expands its BME range - Laboratory Talk

Amsbio expands its BME range - Laboratory Talk | Physiologically Relevant Cell Culture | Scoop.it
Amsbio expands its BME range
Laboratory Talk
Designed for organoid growth and the xenograft models, the BMEs are known as Cultrex BME 2 and Cultrex BME 3.
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