Ethnopharmacology of medicinal plants and Pharmacogenomics
15 views | +0 today
Follow
Your new post is loading...
Your new post is loading...
Scooped by Mohammed Alshawsh
Scoop.it!

Life Saving Medicinal Plants from Pankaj Oudhia's Medicinal Plant Database-8360

Medicinal Plants of India with reference to Biodiversity rich dense forests of Andhra Pradesh, Assam, Karnataka, Kerala, Chhattisgarh, Gujarat, Jharkhand, Ma...
more...
No comment yet.
Scooped by Mohammed Alshawsh
Scoop.it!

"Hepatoprotective effects of Orthosiphon stamineus extract on thioaceta" by Mohammed A. Alshawsh, et al.

"Hepatoprotective effects of Orthosiphon stamineus extract on thioaceta" by Mohammed A. Alshawsh, et al. | Ethnopharmacology of medicinal plants and Pharmacogenomics | Scoop.it
Orthosiphon stamineus as medicinal plant is commonly used in Malaysia for treatment of hepatitis and jaundice; in this study, the ethanol extracts were applied to evaluate the hepatoprotective effects in a thioacetamide-induced hepatotoxic model in Sprague Dawley rats. Five groups of adult rats were arranged as follows:Group 1 (normal control group), Group 2 Thioacetamide (TAA) as positive control (hepatotoxic group), Group 3 Silymarin as a well-known standard drug (hepatoprotective group), and Groups 4 and 5 as high and low dose (treatment groups). After 60-day treatment, all rats were sacrificed. The hepatotoxic group showed a coarse granulation on the liver surface when compared to the smooth aspect observed on the liver surface of the other groups. Histopathological study confirmed the result; moreover, there was a significant increase in serum liver biochemical parameters (ALT, AST, ALP, and Bilirubin) and the level of liver Malondialdehyde (MDA), accompanied by a significant decrease in the level of total protein and Albumin in the TAA control group when compared with that of the normal group. The high-dose treatment group (200mg/kg) significantly restored the elevated liver function enzymes near to normal. This study revealed that 200 mg/kg extracts of O. stamineus exerted a hepatoprotective effect.
Mohammed Alshawsh's insight:

http://www.hindawi.com/journals/ecam/2011/103039/abs/

 

more...
No comment yet.