Parkinson's disease and serotonin
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FDA OKs Pimavanserin for Hallucinations in Parkinson's

FDA OKs Pimavanserin for Hallucinations in Parkinson's | Parkinson's disease and serotonin | Scoop.it
First drug approved for this indication
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Serotonin 5-HT1A Receptors on Astrocytes as a Potential Target for Treatment of Parkinson's Disease.

Serotonin 5-HT1A Receptors on Astrocytes as a Potential Target for Treatment of Parkinson's Disease. | Parkinson's disease and serotonin | Scoop.it
Curr Med Chem. 2016 Jan 21. [Epub ahead of print]
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Antipsychotics increase risk of death in people with Parkinson's disease psychosis - Medical Xpress

Antipsychotics increase risk of death in people with Parkinson's disease psychosis - Medical Xpress | Parkinson's disease and serotonin | Scoop.it
Antipsychotic drugs may increase the risk of death in people with Parkinson's disease psychosis (PDP), according to a new study led by researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London.
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Putaminal serotonergic innervation flags levodopa-induced dyskinesia risk - News-Medical.net

Putaminal serotonergic innervation flags levodopa-induced dyskinesia risk - News-Medical.net | Parkinson's disease and serotonin | Scoop.it
Increased serotonergic fibre innervation relative to dopaminergic fibre availability may be a potential marker of disease progression in Parkinson’s disease patients and a possible warning of levodopa-induced dyskinesia, indicates an in vivo...
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NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat.

NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat. | Parkinson's disease and serotonin | Scoop.it

Published in: Experimental Neurology. 2015 May 30. pii: S0014-4886(15)30008-X. doi: 10.1016/j.expneurol.2015.05.021. [Epub ahead of print]

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Michael J. Fox Foundation Announces New Funding for Alzheimer's, Parkinson's ... - Bioscience Technology

Michael J. Fox Foundation Announces New Funding for Alzheimer's, Parkinson's ... - Bioscience Technology | Parkinson's disease and serotonin | Scoop.it
Michael J. Fox Foundation and Alzheimer’s Association fund $2 million for research projects studying overlap in neurodegenerative diseases.
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Amantadine extended release for levodopa-induced dyskinesia in Parkinson's disease (EASED Study)

Amantadine extended release for levodopa-induced dyskinesia in Parkinson's disease (EASED Study) | Parkinson's disease and serotonin | Scoop.it
This was a randomized, double-blind, placebo-controlled, parallel-group study of 83 PD patients with troublesome dyskinesia assigned to placebo or one of three doses of ADS-5102 (260 mg, 340 mg, 420 mg) administered daily at bedtime for 8 weeks.
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Presynaptic Effects of Levodopa at Serotonin Neurons and Their Possible Role in Dyskinesia - Movement Disorders - 2014

Presynaptic Effects of Levodopa at Serotonin Neurons and Their Possible Role in Dyskinesia - Movement Disorders - 2014 | Parkinson's disease and serotonin | Scoop.it
RT @movedisorder: Presynaptic Effects of Levodopa and Their Possible Role in Dyskinesia http://t.co/wx70NRNt6i
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Tony Mendez, real-life 'Argo' CIA hero, reveals he has Parkinson's disease - Today.com

Tony Mendez, real-life 'Argo' CIA hero, reveals he has Parkinson's disease - Today.com | Parkinson's disease and serotonin | Scoop.it
Tony Mendez, the retired CIA agent played by Ben Affleck in the hit movie "Argo,'' has revealed that he is battling Parkinson's disease. ...
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Central role for the 5-HT system in L-DOPA-derived dopamine synthesis and in dyskinesia [Neuroscience. 2014]

The 5-HT (5-hydroxytryptamine) system has a key role in the development of 3,4-dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia, mainly due to 5-HT neuronal ability to decarboxylate l-DOPA into dopamine. The present work indicates that potential l-DOPA-induced deterioration of 5-HT function might reduce l-DOPA efficacy as well as promote the occurrence of motor side effects.

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05 September 2014 - Neurolixis CEO to present at conference on Neurodegenerative diseases

Dr. Mark A. Varney, PhD., will present at the forthcoming 8th Neurodegenerative Conditions Research & Development meeting to be held September 18-19, 2014 in San Francisco, CA. Dr. Varney has been invited to present in the session on Drug Mechanisms & Treatments in Parkinson's Disease.

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Robin Williams' Parkinson's Disease Diagnosis - TIME

Robin Williams' Parkinson's Disease Diagnosis - TIME | Parkinson's disease and serotonin | Scoop.it

Robin Williams' Parkinson's: The Link Between the Chronic Disease and Depression.

Receiving a positive diagnosis for Parkinson's can be devastating experience...

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Effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease

Effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED)

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22 February 2016 - Just Published: articles on NLX-112 in models of dyskinesia in Parkinson's disease

22 February 2016 - Just Published: articles on NLX-112 in models of dyskinesia in Parkinson's disease | Parkinson's disease and serotonin | Scoop.it
neurolixis joomla3
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Dyskinesia Drug a Step Closer to FDA Approval with Positive Phase III Results

Dyskinesia Drug a Step Closer to FDA Approval with Positive Phase III Results | Parkinson's disease and serotonin | Scoop.it

Adamas has announced positive Phase III results for its treatment for dyskinesia, involuntary movements that are a side effect of levodopa use. Such a therapy could impact how we treat motor symptoms.

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Scientists discover why levodopa can lead to dyskinesia

Scientists discover why levodopa can lead to dyskinesia | Parkinson's disease and serotonin | Scoop.it
Researchers have discovered why long-term use of levodopa, a treatment for Parkinson's disease, commonly leads to a movement problem called dyskinesia.
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Neurolixis Showcased in The Michael J. Fox Foundation’s Partnering Program | PRLog

Neurolixis Showcased in The Michael J. Fox Foundation’s Partnering Program | PRLog | Parkinson's disease and serotonin | Scoop.it
Neurolixis Showcased in The Michael J. Fox Foundation’s Partnering Program. Neurolixis today announced that it had been selected by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to be showcased in its Partnering Program.

Via Neurolixis
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Adamas Pharmaceuticals Receives Orphan Drug Designation for ADS-5102 for ... - MarketWatch

Adamas Pharmaceuticals Receives Orphan Drug Designation for ADS-5102 for ... - MarketWatch | Parkinson's disease and serotonin | Scoop.it
Nasdaq
Adamas Pharmaceuticals Receives Orphan Drug Designation for ADS-5102 for ...
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Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson’s disease: a dose-finding study

Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson’s disease: a dose-finding study | Parkinson's disease and serotonin | Scoop.it
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Association between sleep and levodopa-induced dyskinesia - Neurobiology of Aging

Neurobiol Aging. 2014 Dec 23. pii: S0197-4580(14)00834-3. doi: 10.1016/j.neurobiolaging.2014.12.018. [Epub ahead of print]
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Taking a Stem Cell Shot at Parkinson’s Disease

Taking a Stem Cell Shot at Parkinson’s Disease | Parkinson's disease and serotonin | Scoop.it

Can dopaminergic cells derived from stem cells reverse Parkinson's disease? - Neuroscience News

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L-DOPA treatment correlates with increased Depressive Symptoms in Parkinson's Disease

Depressive symptoms are very common in patients with Parkinson’s disease and have a significant impact on the quality of life. The results of this study show that in patients with PD, higher l-DOPA dosages correlate with worse depressive symptoms. 

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Alkermes Spinoff Civitas Sells to Acorda for $525M on Basis of its Parkinson Medication

Alkermes Spinoff Civitas Sells to Acorda for $525M on Basis of its Parkinson Medication | Parkinson's disease and serotonin | Scoop.it

Acorda today agreed to pay $525 million in cash to acquire Civitas, the Chelsea, MA-based company developing an inhalable version of the decades-old Parkinson’s drug, levodopa (or L-dopa), called CVT-301. ...

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Psychiatric Symptoms Emerge Early in Parkinson’s Disease—And Often Go Untreated

Psychiatric Symptoms Emerge Early in Parkinson’s Disease—And Often Go Untreated | Parkinson's disease and serotonin | Scoop.it

Psychiatric symptoms emerge early in Parkinson's disease and often go untreated (article from American Academy of Neurology)

http://t.co/KUgY4BDcB3

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The Michael J Fox Foundation awards a further research grant to Neurolixis

The Michael J Fox Foundation awards Neurolixis a grant for PK/PD dosing of NLX-112, prior to Phase II trials.

http://t.co/XPAFf06D7T)...

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