Biological systems are known to be robust and evolvable to internal mutations and external environmental changes. What causes these apparently contradictory properties? This study shows that the human signaling network can be decomposed into two structurally distinct subgroups of links that provide both evolvability to environmental changes and robustness against internal mutations. The decomposition of the human signaling network reveals an evolutionary design principle of the network, and also facilitates the identification of potential drug targets.
Kim J, Vandamme D, Kim J-R, Munoz AG, Kolch W, et al. (2014) Robustness and Evolvability of the Human Signaling Network. PLoS Comput Biol 10(7): e1003763. http://dx.doi.org/10.1371/journal.pcbi.1003763