A major goal of synthetic biology is to build reliable, predictable networks of molecular and cellular components that can work as new biological devices capable of, for example, sensing chemicals, manufacturing drugs or even fighting disease. However, achieving such goals entails the production of complex synthetic biocircuits, which requires synchronization of multiple components. Although synchronization is well established in electronics1, synchronizing living cells is a major challenge, because it demands correlation of different phenomena that may be taking place on different temporal and spatial scales. (...) Prindle et al. report that such coupling has been achieved in cells of the bacterium Escherichia coli.
Synthetic biology: Biocircuits in synchrony
Ricard Solé & Javier Macía
Rapid and tunable post-translational coupling of genetic circuits
Arthur Prindle, Jangir Selimkhanov, Howard Li, Ivan Razinkov, Lev S. Tsimring & Jeff Hasty