Despite the successes of genome-wide association studies (GWAS) in identifying genetic connections with human disease, it has become clear that interpreting these data requires a clear understanding of how these new risk genes are regulated. On pages 1118 and 1119 of this issue, Fairfax et al. (1) and Lee et al. (2), respectively, elucidate networks of genetic regulation in the context of the human innate immune system and show how this information can be directly applied to understanding the genetics of autoimmune disorders.
A Genomic Road Map for Complex Human Disease
Peter K. Gregersen
Science 7 March 2014:
Vol. 343 no. 6175 pp. 1087-1088