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Translational Bioinformatics

Translational Bioinformatics | Papers | Scoop.it

'Translational Bioinformatics' is a collection of PLOS Computational Biology Education articles which reads as a "book" to be used as a reference or tutorial for a graduate level introductory course on the science of translational bioinformatics.

Translational bioinformatics is an emerging field that addresses the current challenges of integrating increasingly voluminous amounts of molecular and clinical data. Its aim is to provide a better understanding of the molecular basis of disease, which in turn will inform clinical practice and ultimately improve human health.

 

http://www.ploscollections.org/article/browseIssue.action?issue=info:doi/10.1371/issue.pcol.v03.i11

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What Is Information?: Why Is It Relativistic and What Is Its Relationship to Materiality, Meaning and Organization

We review the historic development of concept of information including the relationship of Shannon information and entropy and the criticism of Shannon information because of its lack of a connection to meaning. We review the work of Kauffman, Logan et al. that shows that Shannon information fails to describe biotic information. We introduce the notion of the relativity of information and show that the concept of information depends on the context of where and how it is being used. We examine the relationship of information to meaning and materiality within information theory, cybernetics and systems biology. We show there exists a link between information and organization in biotic systems and in the various aspects of human culture including language, technology, science, economics and governance.

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