Abnormal metabolism is at the heart of some serious health problems (such as obesity, diabetes and cancer), which not only reduce our life expectancy, but are also a great cost to society. This Insight offers a snapshot of the molecular mechanisms that underlie metabolism and its associated pathology, and showcases the progress made in this buoyant area of research.
Metabolism and disease
Joshua Finkelstein, Noah Gray, Marie Thérèse Heemels, Barbara Marte & Deepa Nath
Nature 491, 347 (15 November 2012)