Much molecular-evolution research is concerned with sequence analysis. Yet these sequences represent real, three-dimensional molecules with complex structure and function. Here I highlight a growing trend in the field to incorporate molecular structure and function into computational molecular-evolution work.
Wilke CO (2012) Bringing Molecules Back into Molecular Evolution. PLoS Comput Biol 8(6): e1002572. http://dx.doi.org/10.1371/journal.pcbi.1002572