An optical blood oxygen sensor attached to an endoscope is able to identify pancreatic cancer in patients via a simple lendoscopic procedure, according to researchers. The study shows that the device, which acts like the well-known clothespin-type finger clip used to measure blood oxygen in patients, has a sensitivity of 92 percent and a specificity of 86 percent.
A new study explains how green tea changed the metabolism of pancreatic cancer cells, opening a new area in cancer-fighting research. Green tea and its extracts have been widely touted as potential treatments for cancer, as well as several other diseases. But scientists have struggled to explain how the green tea and its extracts may work to reduce the risk of cancer or to slow the growth of cancer cells.
Tolulope oni's insight:
I'm glad this study was done specifically for pancreatic cancer. It goes to show that there is a lot to do to keep oneself healthy before any major illness develops.
New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells’ “superpower” to escape death.
By altering a very specific step in gene regulation, this compound essentially re-educates cancer cells into normal cells that die as scheduled.
Tolulope oni's insight:
There is so much research out there that suggests that cancer cells respond to compounds found in food. Aigenin just happens to be one of those compounds. Others include triptolide, resveratrol and EGCG.
Researchers at UCLA have identified a novel approach for the treatment of pancreatic cancer by down-regulating cellular survival factors while concomitantly inducing apoptosis (cell death). The simultaneous administration of plant-derived polyphenolic compounds with inhibitors of reactive oxygen species (ROS) was found to act synergistically to inhibit pancreatic cancer growth and tumor metastasis. Interestingly, one particular polyphenol, rottlerin, exhibited increased potency without the need for ROS-inhibitors. In vivo studies in mice using polyphenols revealed that pancreatic cancer cells selectively underwent apoptosis while non-diseased tissue was unaffected. Experimental evidence has revealed NF-kB, PI 3-kinase and ROS-generators as cell survival targets that are attenuated in this approach. In contrast, the mitochondrial permeability transition pore and caspases have been identified as molecular targets that are responsible for triggering apoptosis. This discovery can potentially be used for the treatment of other cancers, as well as for sensitizing refractory tumors to chemotherapeutic and/or radiation therapies.
Pancreatic cancer is often detected at a late stage, which results in poor prognosis and limited treatment options. Researchers at The Sahlgrenska Academy have now developed a method which identifies the cancer's visible precursors with 97% certainty. The method, which is expected to aid in the early ...
A research team at Georgetown Lombardi Comprehensive Cancer Center reports that inhibiting a single protein completely shuts down growth of pancreatic cancer, a highly lethal disease with no effective therapy.
A drug made from a plant known as “thunder god vine,” or lei gong teng, that has been used in traditional Chinese medicine, wiped out pancreatic tumors in mice, researchers said, and may soon be tested in humans.
Cancer biologists have identified a subpopulation of cells that can give rise to pancreatic cancer. They also found that tumors can form in other, more mature pancreatic cell types, but only when they are injured or inflamed, suggesting that pancreatic cancer can arise from different types of cells depending on the circumstances.
Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumors with an overall five-year survival rate of only 3–5%. Its aggressive biology and resistance to conventional and targeted therapeutic agents lead to a typical clinical presentation of incurable disease once diagnosed. The disease is characterized by the presence of a dense stroma of fibroblasts and inflammatory cells, termed desmoplasia, which limits the oxygen diffusion in the organ, creating a strong hypoxic environment within the tumor. In this review, we argue that hypoxia is responsible for the highly aggressive and metastatic characteristics of this tumor and drives pancreatic cancer cells to oncogenic and metabolic changes facilitating their proliferation. However, the molecular changes leading to metabolic adaptations of pancreatic cancer cells remain unclear. Cachexia is a hallmark of this disease and illustrates that this cancer is a real metabolic disease. Hence, this tumor must harbor metabolic pathways which are probably tied in a complex inter-organ dialog during the development of this cancer. Such a hypothesis would better explain how under fuel source limitation, pancreatic cancer cells are maintained, show a growth advantage, and develop metastasis.
Scientists believe they have discovered a new way to make chemotherapy treatment more effective for pancreatic cancer patients. Pancreatic cancer is an aggressive cancer with poor prognosis and limited treatment options and is highly resistant to chemotherapy and radiotherapy.
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