The transition to multicellularity marks the most pivotal and distinctive events in life’s history on Earth and it only happened a few times in eukaryotes. Multicellularity implies a complex network of regulatory action to coordinate a large number of cell types. Prohaska and co-workers discuss how non-protein-coding RNA (ncRNAs) may have played a crucial role in the development of multicellularity paving the way to the emergence of organism complexity.
Irma Lozada-Chávez, Peter F. Stadler and Sonja J. Prohaska.
A pervasive Non-coding RNA-Based Genetic Regulation is a Prerequisite for the Emergence of Multicellular Complexity. Origins of Life and Evolution of Biospheres. Volume 41, Number 6 (2011), 587-607